[1]段娜娜),王绍欣)#,王丽平),等.经皮冠状动脉封堵法制备中华小型猪急性心肌梗死模型及血清HFABP动态变化的观察[J].郑州大学学报(医学版),2015,(01):78.
 DUAN Nana),WANG Shaoxin),WANG Liping),et al.Establishment of AMI Chinese miniswine model with percutaneous coronary occlusion and observation on dynamic change of serum HFABP level[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(01):78.
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经皮冠状动脉封堵法制备中华小型猪急性心肌梗死模型及血清HFABP动态变化的观察
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年01期
页码:
78
栏目:
应用研究
出版日期:
2015-01-20

文章信息/Info

Title:
Establishment of AMI Chinese miniswine model with percutaneous coronary occlusion and observation on dynamic change of serum HFABP level
作者:
段娜娜1)王绍欣1)#王丽平1)王宏运1)董平栓1)汪砚雨1)王可1)李转珍1)魏丽娟2)陈士芳1)孟雅丽1)闫鹏1)刘向勇1)程建新1)
1)河南科技大学第一附属医院心血管内科 洛阳 4710032)河南科技大学第一附属医院麻醉科 洛阳 471003
Author(s):
DUAN Nana1)WANG Shaoxin1)WANG Liping1)WANG Hongyun1)DONG Pingshuan1)WANG Yanyu1)WANG Ke1)LI Zhuanzhen1)WEI Lijuan2)CHEN Shifang1) MENG Yali1)YAN Peng1)LIU Xiangyong1)CHENG Jianxin1)
1)Department of Cardiology, the First Affiliated Hospital, Henan University of Science and Technology, Luoyang 4710032)Department of Anesthesiology, the First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003
关键词:
急性心肌梗死心脏型脂肪酸结合蛋白动物模型中华小型猪
Keywords:
acute myocardial infarctionhearttype fatty acidbinding proteinanimal modelChinese miniswine
分类号:
R544.1
摘要:
摘要目的:探讨经皮冠状动脉封堵法建立中华小型猪急性心肌梗死(AMI)模型的可行性,并观察血清心脏型脂肪酸结合蛋白(HFABP)的动态变化规律。方法:16头中华小型猪全麻后Seldinger法穿刺右侧股动脉,行冠状动脉造影后经微导管注入明胶海绵封堵钝缘(OM)支。分别检测术前,术后0.5、1.0、2.0、3.0、4.0、6.0、8.0、10.0、12.0、24.0和48.0 h等时间点血清HFABP水平。 结果:15头中华小型猪均成功栓塞OM支,AMI后心电图呈ST段弓背向上抬高表现,说明造模成功。血清HFABP水平于AMI后0.5 h开始升高,8.0 h达到峰值,24.0 h后逐渐回落至正常(F=4.460,P<0.001)。 结论:经皮冠状动脉内明胶海绵封堵法制备中华小型猪AMI模型实用性强;通过监测AMI后HFABP的血清浓度动态变化,可为AMI患者的极早期诊治提供参考。
Abstract:
AbstractAim: To evaluate the mean of percutaneous coronary occlusion to establish Chinese miniswine acute myocardial infarction(AMI) model,and observe dynamic change of serum hearttype fatty acidbinding protein(HFABP). Methods: The obtuse marginal(OM) branch of 16 Chinese miniswines were blocked by gelatin sponge via microcatheter under general anesthesia through Seldinger right femoral artery puncture after coronary angiography. Serum HFABP concentrations before AMI and at the 0.5,1.0, 2.0, 3.0, 4.0, 6.0, 8.0, 10.0, 12.0, 24.0 and 48.0 h after AMI were determined. Results: The OM branches of 15 Chinese miniswines were successfully blocked.Serum HFABP began to increase 0.5 h after operation, and reached the peak after 8.0 h,and then gradually fell back to normal after 24.0 h. Conclusion: It is practical to copy miniswine AMI model by percutaneous coronary occlusion. Monitoring the serum HFABP concentrations can provide clinical data for early diagnosis and treatment of patients with AMI .

参考文献/References:

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备注/Memo

备注/Memo:
#通信作者,男,1964年1月生,主任医师,教授,研究方向:急性心肌梗死,E-mail:wsxdoctor@163.com
更新日期/Last Update: 1900-01-01