[1]肖静,卢珊,刘栋,等.DNA免疫吸附治疗重症系统性红斑狼疮的临床观察*[J].郑州大学学报(医学版),2015,(01):98.
 XIAO Jing,LU Shan,LIU Dong,et al.Therapeutic effects of DNA immunoadsorption therapy on severe systemic lupus erythematosus[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(01):98.
点击复制

DNA免疫吸附治疗重症系统性红斑狼疮的临床观察*
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年01期
页码:
98
栏目:
应用研究
出版日期:
2015-01-20

文章信息/Info

Title:
Therapeutic effects of DNA immunoadsorption therapy on severe systemic lupus erythematosus
作者:
肖静卢珊刘栋张晓雪王晓阳胡冬怡赵占正#
郑州大学第一附属医院肾脏病中心;郑州大学肾脏病研究所 郑州 450052
Author(s):
XIAO Jing LU Shan LIU Dong ZHANG Xiaoxue WANG Xiaoyang HU Dongyi ZHAO Zhanzheng
Center of Nephrology, the First Affiliated Hospital,Zhengzhou University;Kidney Disease Research Institute, Zhengzhou University, Zhengzhou 450052
关键词:
系统性红斑狼疮免疫吸附血液净化
Keywords:
systemic lupus erythematosus immunoadsorption blood purification
分类号:
R593.24+1
摘要:
摘要目的:探讨DNA免疫吸附治疗重症系统性红斑狼疮(SLE)的临床有效性、安全性。方法:收集重症SLE患者20例,分为观察组(8例)和对照组(12例)。观察组采用连续性血液净化联合DNA免疫吸附配合泼尼松片、环磷酰胺治疗,对照组采用甲强龙冲击后,给予泼尼松片联合环磷酰胺治疗。比较2组患者治疗前及治疗12周、24周SLEDAI评分及ANA、抗dsDNA抗体滴度,IgG,IgA,IgM,C3,C4,肾功能等指标。结果:与对照组比较,治疗12周观察组SLEDAI评分、ANA与抗dsDNA抗体滴度下降更快(P均<0.05),24周时观察组ANA滴度仍能维持在较低水平(P均<0.05)。治疗24周,2组患者肾功能均稳定。观察组除1例发生重症感染,无精神异常、心律失常等不良反应发生。结论:DNA免疫吸附治疗重症SLE安全、有效。
Abstract:
AbstractAim: To investigate the clinical efficacy and safety of DNA immunoadsorption on patients with severe systemic lupus erythematosus(SLE).Methods: Twenty cases of severe SLE were allocated into 2 groups; observation group(n=8) received continuous blood purification, DNA immunoadsorption and glucocorticoid treatment,and control group (n=12) received cyclophosphamide combined with glucocorticoid treatment. Before and at 12 and 24 weeks after the therapy, SLEDAI score, autoantibodies(ANA) and antidsDNA autoantibody titer, IgG, IgA, IgM levels, C3 and C4 and renal function parameters were assessed. Results: At 12 weeks after the treatment, the SLEDAI score, ANA and antidsDNA autoantibody titer in the observation group decreased more significantly than control group; at 24 weeks after the treatment, the ANA titer in the observation group still maintained in a low level(P<0.05). The renal function were stable in two groups during 24 weeks. There were no obvious side effects except for a case of severe infection. Conclusion: DNA immunoadsorption in treatment of severe SLE is effective and safe.

参考文献/References:

参考文献 [1]岳孟龙,刘沛东,刘洪波,等.系统性红斑狼疮合并视神经脊髓炎2例及文献复习[J].郑州大学学报:医学版,2014,49(3):422 [2]Hu WX,Liu ZZ,Chen HP,et al.Clinical characteristics and prognosis of diffuse proliferative lupus nephritis with thrombotic microangiopathy[J].Lupus,2010,19(14):1591 [3]Kong D,Schuett W,Dai J,et al.Development of celluloseDNA immunoadsorbent[J].Artif Organs,2002,26(2):200 [4]章海涛,胡伟新,季大玺,等.免疫吸附治疗合并血管病变的重症狼疮性肾炎[J].肾脏病与透析肾移植杂志,2008,17(6):501 [5]Hochberg MC.Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus[J].Arthritis Rheum,1997,40(9):1725 [6]中华医学会风湿病学分会.系统性红斑狼疮诊断及治疗指南[J].中华风湿病学杂志,2010,14(5):342 [7]Bombardier C,Gladman DD,Urowitz MB,et al.Derivation of the SLEDAI.A disease activity index for lupus patients.The Committee on Prognosis Studies in SLE[J].Arthritis Rheum,1992,35(6):630 [8]何朝生,史伟,叶智明,等.系统性红斑狼疮患者心血管事件发生的回顾调查:879例系统性红斑狼疮横断面研究[J].南方医科大学学报,2011,31(11):1910 [9]Cameron JS.Lupus nephritis[J].J Am Soc Nephrol,1999,10(2):413 [10]周娟,唐雪梅.系统性红斑狼疮生物制剂治疗研究进展[J].中华实用儿科临床杂志,2013,28(21):1669 [11]Braun N,Erley C,Klein R,et al.Immunoadsorption onto protein A induces remission in severe systemic lupus erythematosus[J].Nephrol Dial Transplant,2000,15(9):1367 [12]Stummvoll GH,Aringer M,Smolen JS,et al.IgG immunoadsorption reduces systemic lupus erythematosus activity and proteinuria: a long term observational study[J].Ann Rheum Dis,2005,64(7):1015 [13]宁军,许雪芳,黄卫华,等.免疫吸附联合糖皮质激素和环磷酰胺治疗重症系统性红斑狼疮的临床观察[J].临床肾脏病杂志,2012,12(2):72

相似文献/References:

[1]王春燕),王许娜),朱伟涛),等.系统性红斑狼疮患者血清抗核小体抗体和抗核糖体P蛋白抗体检测[J].郑州大学学报(医学版),2009,(04):836.
 WANG Chunyan),WANG Xuna),ZHU Weitao),et al.Detection of serum antinuclearsome antibody and antiribosomal P protein antibody in systemic lupus erythematosus[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2009,(01):836.
[2]王学清,张瑞芳.系统性红斑狼疮35例右心功能组织多普勒分析[J].郑州大学学报(医学版),2009,(04):878.
[3]李君凡,李尚珠,黄平平,等.系统性红斑狼疮伴血小板减少症93例疗效观察及相关因素分析[J].郑州大学学报(医学版),2009,(03):662.
[4]董忠生,李素娟,佘红纯,等.河南汉族系统性红斑狼疮患者HS1基因EPEP插入多态性检测[J].郑州大学学报(医学版),2010,(05):838.
[5]史晓飞,赵占正#,刘升云,等.狼疮肾炎患者肾组织中Toll样受体9的表达[J].郑州大学学报(医学版),2010,(06):977.
[6]王岩青.系统性红斑狼疮患者左心室功能的超声心动图评价[J].郑州大学学报(医学版),2011,(05):780.
[7]张继要,罗强#,史丹丹.儿童系统性红斑狼疮继发干燥综合征1例[J].郑州大学学报(医学版),2012,(02):279.
[8]苏利沙),张根豪),邓少丽),等.常用免疫抑制剂治疗对系统性红斑狼疮患者淋巴细胞亚群的影响*[J].郑州大学学报(医学版),2014,(02):236.
 SU Lisha,ZHANG Genhao,DENG Shaoli,et al.Changes of lymphocyte subsets in systemic lupus erythematosus patients after common immunosuppressant therapy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2014,(01):236.
[9]岳孟龙),刘沛东),刘洪波)#,等.系统性红斑狼疮合并视神经脊髓炎2例及文献复习[J].郑州大学学报(医学版),2014,(03):422.

备注/Memo

备注/Memo:
*河南省卫生厅科技攻关计划资助项目201003046 #通信作者,男,1970年10月生,博士,教授,主任医师,研究方向:慢性肾脏病的防治,E-mail:13938525666@139.com
更新日期/Last Update: 1900-01-01