[1]徐荣荣,杨国杰#.心力衰竭小鼠心肌组织中4.1R蛋白的表达*[J].郑州大学学报(医学版),2015,(01):104.
 XU Rongrong,YANG Guojie.Expression of 4.1R in myocardial tissue from mice with heart failure[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(01):104.
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心力衰竭小鼠心肌组织中4.1R蛋白的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年01期
页码:
104
栏目:
应用研究
出版日期:
2015-01-20

文章信息/Info

Title:
Expression of 4.1R in myocardial tissue from mice with heart failure
作者:
徐荣荣杨国杰#
郑州大学第一附属医院老年病科;河南省高等学校临床医学重点学科开放实验室 郑州 450052
Author(s):
XU Rongrong YANG Guojie
Department of Geriatrics, the First Affiliated Hospital,Zhengzhou University;KeyDisciplines Laboratory for Clinical Medicine of Henan Province,Zhengzhou 450052
关键词:
心力衰竭4.1R蛋白小鼠
Keywords:
heart failure 4.1R mouse
分类号:
R541
摘要:
摘要目的:探讨心力衰竭(心衰)小鼠心肌组织中4.1R蛋白的表达及其与心功能的关系。方法:42只雄性健康小鼠随机分为心衰组(n=22)和对照组(n=20)。处死小鼠后迅速取出心肌组织,行HE染色,计算左室质量指数和心肌病理积分;并采用免疫组化染色及免疫荧光标记法检测心衰小鼠心肌组织4.1R蛋白的表达。结果:与对照组比较,心衰组左室质量指数和心肌病理积分升高(t=190.668,Z=31.915,P均<0.05);心衰组心肌组织4.1R蛋白阳性细胞百分比高于对照组(t=18.607,P=0.001)。Pearson直线相关分析显示,心衰组心肌组织4.1R蛋白阳性细胞百分比与左室质量指数呈正相关(r=0.766,P<0.001)。结论:心衰小鼠心肌组织中4.1R蛋白的表达增加,干预4.1R蛋白的表达可能对心衰的治疗及预后有一定的意义。
Abstract:
AbstractAim: To detect the expression of 4.1R in myocardial tissue from mice with heart failure(HF) and its relationship with cardiac function. Methods: A total of 42 male mice were randomly allocated into HF group (n=22) and control group (n=20). All the mice were killed and the myocardial tissue was prepared for HE staining. The left ventricular mass index and the myocardial tissue pathological score were assessed. The expression of 4.1R in myocardial tissue was detected by immunohistochemistry and immunofluorescence. Results: Compared with control group, the left ventricular mass index and the myocardial tissue pathological score in the HF group increased (t=190.668,Z=31.915,P<0.05). The positive rate of 4.1R in the HF group was significantly higher than that in control group(t=18.607, P=0.001). In the HF group, the positive correlation was found between the left ventricular mass index and the positive rate of 4.1R in myocardial tissue(r=0.766,P<0.001).Conclusion: The expression of 4.1R in myocardial tissue from mice with HR is increased and intervention of the expression of 4.1R may be helpful in the treatment and prognosis of HR.

参考文献/References:

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备注/Memo

备注/Memo:
*郑州市科技局创新团队项目131PCXTD632 #通信作者,男,1962年10月生,博士,教授,主任医师,研究方向:心力衰竭的防治,E-mail:yang63315@126.com
更新日期/Last Update: 1900-01-01