[1]李廷坤,汪蕾,孙亚林,等.右美托咪定对丙泊酚全麻患者恢复期脑电双频指数和血流动力学的影响*[J].郑州大学学报(医学版),2015,(01):107.
 LI Tingkun,WANG Lei,SUN Yalin,et al.Effect of dexmedetomidine on bispectral index and haemodynamics during propofol anesthesia recovery period[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(01):107.
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右美托咪定对丙泊酚全麻患者恢复期脑电双频指数和血流动力学的影响*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年01期
页码:
107
栏目:
应用研究
出版日期:
2015-01-20

文章信息/Info

Title:
Effect of dexmedetomidine on bispectral index and haemodynamics during propofol anesthesia recovery period
作者:
李廷坤汪蕾孙亚林吕帅国王根生卢锡华#
郑州大学附属肿瘤医院麻醉科 郑州 450008
Author(s):
LI TingkunWANG Lei SUN YalinLV ShuaiguoWANG GenshengLU Xihua
Department of Anesthesiology,Tumor Hospital Affiliated to Zhengzhou University, Zhengzhou 450008
关键词:
右美托咪定脑电双频指数血流动力学
Keywords:
dexmedetomidine bispectral index haemodynamics
分类号:
R614.2+4
摘要:
摘要目的:观察右美托咪定对丙泊酚全麻恢复期脑电双频指数(BIS)和血流动力学的影响。方法:选择ASAⅠ或Ⅱ级全麻患者40例,分为右美托咪定组和对照组2组。诱导前右美托咪定组使用微量注射泵静脉输注右美托咪定1 μg/kg(15 min),对照组以同样方式输注等量生理盐水。记录麻醉诱导前、吸痰时、拔管即刻和拔管后1、5、10 min的心率(fH)和平均动脉压(pMA)及BIS。结果:2组fH(F组间=23.635,F时间=13.421,P均<0.05)和pMA(F组间=3.790,F时间=3.461,P均<0.05)组间比较差异有统计学意义;对照组在吸痰时、拔管时及拔管后1和5 min时fH增快,pMA升高,与诱导前相比差异有统计学意义(P<0.05);右美托咪定组在吸痰时、拔管时、拔管后fH 和pMA较为平稳,与麻醉诱导前相比差异均无统计学意义(P>0.05)。2组间各时点BIS比较差异无统计学意义(P>0.05)。结论:麻醉诱导前使用1 μg/kg右美托咪定不影响全麻恢复期BIS,而且能够稳定全麻恢复期血流动力学。
Abstract:
AbstractAim: To observe the effect of dexmedetomidine on bispectral index(BIS) and haemodynamics during the propofol anesthesia recovery period.Methods: Forty patients with general anesthesia at ASAⅠorⅡlevel were selected and randomly allocated into 2 groups: dexmedetomidine group(1 μg/kg) and control group.Corresponding medicines were injected through vein before anesthesia induction and the injection was completed within 15 min.The heart rate(fH),mean arterial pressure(pMA) and BIS were recorded before anesthesia induction,when the sputum suction,at the end of tracheal extubation and 1, 5, 10 min after tracheal extubation. Results: There were significant differences in fH(Fgroup=23.635,Ftime=13.421,P<0.05) and pMA (Fgroup=3.790,Ftime=3.461,P<0.05) between the 2 groups. At the sputum suction, extubation and 1 and 5 min after the extubation,compared with control group,fH and pMA of dexmedetomidine group were higher(P<0.05).There was no statistical difference in BIS between dexmedetomidine group and control group at different time points(P>0.05). Conclusion: The use of 1 μg/kg dexmedetomidine before anesthesia induction does not effect BIS during propofol anesthesia recovery period, and brings stable haemodynamics during propofol anesthesia recovery period.

参考文献/References:

参考文献 [1]Huupponen E,Maksimow A,Lapinlampi P,et al.Electroencephalogram spindle activity during dexmedetomidine sedation and physiological sleep[J].Acta Anaesthesiol Scand,2008,52(2):289 [2]陈冰,刘昊川,陈鹏,等.右旋美托咪定对全髋置换择期手术全身麻醉患者围拔管期血流动力学及苏醒过程的影响[J].吉林大学学报:医学版,2013,39(4):804 [3]吴刚,薛荣亮,吕建瑞,等.脑电双频指数调控下的全凭静脉麻醉在小儿腹腔镜手术中的应用[J].西安交通大学学报:医学版,2011,32(5):619 [4]施蕾蕾,邵东华,杭黎华,等.右美托咪啶对脑电双频指数监测丙泊酚全麻镇静深度准确性的影响[J].江苏大学学报:医学版,2013,23(4):357 [5]葛春林,景亮.不同年龄患者靶控输注丙泊酚的血药浓度与脑电双频指数值的相关性[J].临床麻醉学杂志,2007,23(7):533 [6]肖亮灿,李坤河,李毅,等.腹部手术中右旋美托咪定对全凭静脉麻醉的影响[J].中山大学学报:医学科学版,2012,33(5):649

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备注/Memo

备注/Memo:
*河南省医学科技攻关项目200903145 #通信作者,男,1966年11月生,硕士,主任医师,研究方向:肿瘤患者的手术麻醉,E-mail:hnlxh66@163.com
更新日期/Last Update: 1900-01-01