[1]徐筱跃△.射血分数正常的心功能不全患者血清生长抑素受体2的检测[J].郑州大学学报(医学版),2015,(01):114.
 XU Xiaoyue.Assessment of serum somatostatin receptor 2 levels in cases of heart failure with normal ejection fraction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(01):114.
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射血分数正常的心功能不全患者血清生长抑素受体2的检测
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年01期
页码:
114
栏目:
应用研究
出版日期:
2015-01-20

文章信息/Info

Title:
Assessment of serum somatostatin receptor 2 levels in cases of heart failure with normal ejection fraction
作者:
徐筱跃△
乐山职业技术学院生理学教研室 乐山 614000
Author(s):
XU Xiaoyue
Department of Physiology, Leshan Vocational & Technical College,Leshan 614000
关键词:
射血分数心功能不全生长抑素受体2
Keywords:
ejection fractionheart failuresomatostatin receptor 2
分类号:
R541
摘要:
摘要目的:评估射血分数正常的心功能不全(HFNEF)患者血清生长抑素受体2(SSTR2)和血中N末端脑钠肽前体(NTpro BNP)表达的变化。方法:选取自2010年4月至2013年4月住院的97例HFNEF患者和76名健康人进入研究。用免疫荧光加微激光技术和ELISA法分别检测所有研究对象血清SSTR2和气血NTpro BNP的水平,并与研究对象的临床资料和超声心动图进行比较。绘制ROC曲线,选定SSTR2诊断HFNEF的最佳阈值。结果:HFNEF组患者SSTR2、NTpro BNP水平均明显高于健康人组(P<0.001)。HFNEF患者SSTR2水平与心功能分级、LAD、IVST、LVPWT、E/Ea、NTpro BNP水平呈正相关(r=0.511、0.378、0.334、0.420、0.403和0.446,P<0.05);与LVEF呈负相关(r=-0.613,P<0.001)。SSTR2的诊断曲线下面积为0.873(95%CI:0.812~0.899,P<0.001),优于NTpro BNP的诊断曲线下面积0.664(95%CI:0.622~0.689, P=0.042),两者联合诊断的ROC曲线下面积为0.899(95%CI:0.875~0.921, P=0.033)。根据ROC曲线结果,当SSTR2的诊断阈值为10.9 μg/L时,其诊断的灵敏度为73%,特异度为82%。结论:血清SSTR2对HFNEF患者心室重塑的早期诊断具有重要意义,与NTpro BNP联合诊断HFNEF的效果更佳。
Abstract:
AbstractAim: To assess the levels of serum somatostatin receptor 2(SSTR2) and Nterminal probrain natriuretic peptide (NTpro BNP) levels in cases of heart failure with normal ejection fraction(HFNEF). Methods: Serum level of SSTR2 and whole blood level of NTpro BNP in 97 HFNEF patients and 76 healthy controls were measured by immunoassay and ELISA. Clinical features and ultrasonic cardiographic parameters of patients in two groups were analyzed. ROC curves were drawn to evaluate the diagnostic value of SSTR2. The best cutoff value of SSTR2 for diagnosis of HFNEF was defined. Results: The serum level of SSTR2 was significantly increased in HFNEF group compared with healthy controls(P<0.001). Serum SSTR2 was positively correlated with NYHA class(r=0.511), LAD(r=0.378), IVST(r=0.334), LVPWT(r=0.420),E/Ea(r=0.403), NTpro BNP(r=0.446) and negatively correlated with LVEF(r=-0.613). ROC curves for diagnosis of HFNEF demonstrated an AUC of 0.873 for SSTR2 (95%CI:0.812-0.899,P<0.001), an AUC of 0.664 for NTpro BNP (95%CI:0.622-0.689, P=0.042), an AUC of 0.899 for SSTR2 combined with NTpro BNP (95%CI:0.875-0.921, P=0.033). When the threshold of SSTR2 was set at 10.9 μg/L, the sensitivity and specificity were 73% and 82%, respectively. Conclusion: SST2 measurement provides diagnostic aid of ventricular remodeling for HFNEF patients. Addition of NTproBNP to SST2 could give further information.

参考文献/References:

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备注/Memo

备注/Memo:
△男,1961年6月生,博士,副教授,研究方向:生理学,E-mail:422579731@qq.com
更新日期/Last Update: 1900-01-01