[1]赵花,张丽侠,郑丽丽#.2型糖尿病患者血糖控制水平对骨密度的影响[J].郑州大学学报(医学版),2015,(01):124.
 ZHAO Hua,ZHANG Lixia,ZHENG Lili.Effects of glycemic control station on bone mineral density in patients with type 2 diabetes mellitus[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(01):124.
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2型糖尿病患者血糖控制水平对骨密度的影响
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年01期
页码:
124
栏目:
应用研究
出版日期:
2015-01-20

文章信息/Info

Title:
Effects of glycemic control station on bone mineral density in patients with type 2 diabetes mellitus
作者:
赵花张丽侠郑丽丽#
郑州大学第一附属医院内分泌科;河南省高等学校临床医学重点学科开放实验室 郑州 450052
Author(s):
ZHAO HuaZHANG LixiaZHENG Lili
Department of Endocrinology, the First Affiliated Hospital, Zhengzhou University;KeyDisciplines Laboratory for Clinical Medicine of Henan Province,Zhengzhou 450052
关键词:
2型糖尿病骨密度糖化血红蛋白血糖控制
Keywords:
type 2 diabetes mellitusosteoporosisbone mineral densityHbA1cglycemic control
分类号:
R587.1
摘要:
摘要目的:探讨2型糖尿病(T2DM)患者血糖控制水平对骨密度的影响。方法:纳入T2DM患者170例,其中绝经前女性T2DM患者(A1组)21例,绝经后女性T2DM患者(A2组)79例,小于50岁男性T2DM患者(B1组)22例,50岁及以上男性T2DM患者(B2组)48例。应用双能X线骨密度仪测定所有患者腰椎(L2、L3、L4和L2~4)及股骨近端[(股骨颈(FN)、大转子(TM)和Wards三角区(WA)]的骨密度。以各部位骨密度为因变量,以糖化血红蛋白(HbA1c)、年龄、体重指数、病程等可能影响骨密度的因素为自变量,建立多重线性回归模型,分析血糖控制水平是否对T2DM患者骨密度有影响。 结果:A1组未发现HbA1c水平对骨密度有影响。A2组中HbA1c水平对L2、L3、L4和L2~4的骨密度有影响(β=-0.579、-0.556、-0.614和-0.476,P均<0.05)。B1组中HbA1c水平对L4、L2~4和WA的骨密度有影响(β=-0.443、-0.284和-0.227,P均<0.05)。B2组中HbA1c水平对L4、L2~4和TM的骨密度有影响(β=-0.745、-0.297和-0.147,P均<0.05)。结论:T2DM患者血糖控制水平是骨密度的影响因素,尤其是对于男性及绝经后女性患者。
Abstract:
AbstractAim: To evaluate the effects of glycemic control station on bone mineral density(BMD) in patients with type 2 diabetes mellitus(T2DM). Methods: A total of 170 patients with T2DM were enrolled in the study. These patients included premenopausal female patients (group A1,21 cases), postmenopausal female patients (group A2,79 cases), male patients less than 50 years old (group B1,22 cases) and male patients of 50 years old or older(group B2,48 cases). BMD of lumbar vertebra (L2, L3, L4, L2-4) and hip [femoral neck(FN), trochanter major(TM) and wards area(WA)] were detected by dual energy Xray absorptiometry. Glycosylated hemoglobin A1c (HbA1c) was detected by high performance liquid chromatography method. Multiple regression analysis was employed with HbA1c, BMI, age and duration as independent variants and BMD as the dependence variant.Results: There were no significant correlations between BMD and HbA1c in group A1. However, BMD of L2, L3, L4 and L2-4 in group A2(β=-0.579,-0.556,-0.614 and -0.476,P<0.05), BMD of L4, L2-4 and WA in group B1(β=-0.443,-0.284 and -0.227,P<0.05) and that of L4, L2-4 and TM in group B2(β=-0.745,-0.297 and -0.147,P<0.05) were affected by HbA1c.Conclusion: Glycemic control station could affect the maintainance of BMD in male and postmenopausal female patients with T2DM.

参考文献/References:

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备注/Memo

备注/Memo:
#通信作者,女,1956年10月生,博士,教授,研究方向:糖尿病及血管并发症、骨质疏松的防治,E-mail:zhengli1012@126.com
更新日期/Last Update: 1900-01-01