[1]仝晨均),付晓丽)#,付余),等.左旋肉碱对肥胖患者血脂水平影响的meta分析*[J].郑州大学学报(医学版),2015,(02):214.
 TONG Chenjun),FU Xiaoli,FU Yu,et al.A metaanalysis of effect of Lcarnitine on lipid levels in obese patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(02):214.
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左旋肉碱对肥胖患者血脂水平影响的meta分析*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年02期
页码:
214
栏目:
应用研究
出版日期:
2015-03-20

文章信息/Info

Title:
A metaanalysis of effect of Lcarnitine on lipid levels in obese patients
作者:
仝晨均1)付晓丽2)#付余2)宋金露1)
1)郑州大学药学院 郑州 4500012)郑州大学公共卫生学院 郑州 450001
Author(s):
TONG Chenjun1)FU Xiaoli2)FU Yu2)SONG Jinlu1)
1)College of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 4500012)College of Public Health,Zhengzhou University, Zhengzhou 450001
关键词:
左旋肉碱血脂肥胖meta分析
Keywords:
Lcarnitinelipidobesitymetaanalysis
分类号:
R969.4
摘要:
目的:采用meta分析明确左旋肉碱与肥胖患者血脂水平的关系。方法:按照系统评价的要求,检索左旋肉碱用于减肥的随机对照试验,对纳入的研究进行质量评价和meta分析。结果:试验组和对照组在TG减少(WMD=0.883,95%CI=-0.230~1.980,Z=1.560,P=0.120)、 TC减少(WMD=-0.060,95%CI=-0.150~0.020,Z=1.520,P=0.130)、HDL减少(WMD=0.040,95%CI=-0.270~0.360,Z=0.270,P=0.790)方面差异均无统计学意义,在LDL减少(WMD=1.080,95%CI=-0.560~2.730,Z=1.290,P=0.020)方面差异有统计学意义。结论:左旋肉碱通过改善肥胖患者的LDL水平,调控肥胖患者脂肪代谢。
Abstract:
Aim: To evaluate the relationship between Lcarnitine and lipid levels in obese patients. Methods: According to the requirements of system evaluation, randomized controlled trials of Lcarnitine for weight loss were collected. The quality of the included studies was evaluated and metaanalysis was performed. Results: Reduction in the TG(WMD=0.883,95%CI=-0.230-1.980,Z=1.560,P=0.120), TC(WMD=-0.060,95%CI=-0.150-0.020,Z=1.520,P=0.130), and HDL(WMD=0.040,95%CI=-0.270-0.360,Z=0.270,P=0.790) between the intervention and control groups had no statistical difference; LDL reduction(WMD=1.080,95%CI=-0.560-2.730,Z=1.290,P=0.020) between the 2 groups had statistical difference.Conclusion: Lcarnitine could improve the LDL level of obese patients thus regulating the fat metabolism in obese patients.

参考文献/References:

[1]杨敏,牟金金,柳汝明,等.左旋肉碱用于减肥的系统评价[J].中国药房,2012,23(2):147 [2]李延兵,梁奕铨,秦婉文,等.左旋肉碱在超重2型糖尿病病人中的作用[J].中山医科大学学报,2000,21(3):215 [3]黄宗锈,林健,林春芳.左旋肉碱对肥胖人员减肥作用的效果观察[J].预防医学论坛,2007,13(1):6 [4]周书凤,何志谦,刘建平,等.左旋肉碱对肥胖青少年体重综合性控制的影响[J].营养学报,1997,19(2):8 [5]Gwak JH,Lee J.The effect of Lcarnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women[J].Korean J Nutr,2007,40(7):630 [6]范雪,严政.L肉碱与有机铬对举重运动员脂肪控制的影响[J].南京体育学院学报:自然科学版,2007,6(3):41 [7]周斅激.L肉碱配合有氧运动对肥胖女性脂肪代谢的影响[J].天津体育学院学报,2004,19(4):60 [8]Malaguarnera M,Vacante M,Avitabile T,et al.Lcarnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes[J].Am J Clin Nutr,2009,89(1):71 [9]Nakamura T,Sugihara H,Kinoshita N,et al.Can serum carnitine levels distinguish hypertrophic cardiomyopathy from hypertensive hearts?[J].Hypertension,2000,36(2):215 [10]乔玲,卢锋,欧阳春花.魔芋精粉和左旋肉碱对肥胖人膳食干预的效果[J].解放军预防医学杂志,2005,23(2):86

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备注/Memo

备注/Memo:
*国家自然科学基金项目H2610
更新日期/Last Update: 1900-01-01