[1]郭华峰)△,杨筱青),古雅丽),等.胎膜早破和绒毛膜羊膜炎患者胎膜组织中MMP9、MIF的表达和羊水中IL6水平检测*[J].郑州大学学报(医学版),2015,(02):229.
 GUO Huafeng),YANG Xiaoqing),GU Yali),et al.Expressions of MMP9,MIF in fetal membranes and IL6 level in amniotic fluid of pregnant women with premature rupture of membranes or chorioamnionitis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(02):229.
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胎膜早破和绒毛膜羊膜炎患者胎膜组织中MMP9、MIF的表达和羊水中IL6水平检测*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年02期
页码:
229
栏目:
应用研究
出版日期:
2015-03-20

文章信息/Info

Title:
Expressions of MMP9,MIF in fetal membranes and IL6 level in amniotic fluid of pregnant women with premature rupture of membranes or chorioamnionitis
作者:
郭华峰1)△杨筱青1)古雅丽2)陈慧萍2)
1)郑州市妇幼保健院妇产科 郑州 4500122)郑州市妇幼保健院病理科 郑州 450012
Author(s):
GUO Huafeng1)YANG Xiaoqing1)GU Yali2)CHEN Huiping2)
1)Department of Gynecology and Obstetrics,Zhengzhou Maternal and Child Care Service Center, Zhengzhou 4500122)Department of Pathology,Zhengzhou Maternal and Child Care Service Center, Zhengzhou 450012
关键词:
胎膜早破绒毛膜羊膜炎基质金属蛋白酶9巨噬细胞移动抑制因子白细胞介素6
Keywords:
premature rupture of membranechorioamnionitisMMP9MIFIL6
分类号:
R714
摘要:
目的:探讨胎膜早破(PROM)和绒毛膜羊膜炎(CAM)患者胎膜组织中基质金属蛋白酶9(MMP9)、巨噬细胞移动抑制因子(MIF)表达及羊水白细胞介素6(IL6)水平变化的意义。方法:选择足月PROM剖宫产产妇50例(PROM组)和同期足月无PROM剖宫产产妇60例(对照组),剖宫产术中抽取羊水行IL6水平检测,并采用免疫组织化学方法检测胎膜组织中MMP9、MIF的表达。结果:PROM组CAM发生率、羊水IL6水平和胎膜组织中MMP9、MIF表达均高于对照组(χ2=23.973,t=5.817,Z=3.507,Z=2.678,P<0.05)。组织学诊断为CAM的产妇羊水IL6水平、胎膜组织中MMP9、MIF表达均高于非CAM产妇(P<0.05)。结论:PROM和CAM互为因果,MMP9、MIF和IL6平衡失调可能导致CAM。
Abstract:
Aim: To explore the changes of the expressions of MMP9,MIF in fetal membranes and IL6 level in amniotic fluid of pregnant women with premature rupture of membranes(PROM) or chorioamnionitis(CAM). Methods: A total of 50 fullterm pregnant women with PROM(PROM group) and 60 cases without PROM(control group) underwent term cesarean delivery were selected to detect the expressions of MMP9,MIF in fetal membranes using immunohistochemical method and the level of IL6 in amniotic fluid using ELISA. Results: The CAM incidence, the level of IL6 in amniotic fluid, and MMP9,MIF expressions of PROM group were higher than those of the control group(χ2=23.973,t=5.817,Z=3.507,2.678,P<0.05). The indexes mentioned above of the women with CAM diagnosed histologically were higher than those of nonCAM women(P<0.05). Conclusion: PROM and CAM might be causal; imbalance among MMP9, MIF and IL6 may lead to CAM.

参考文献/References:

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备注/Memo

备注/Memo:
*河南省科技发展计划项目132102310144
更新日期/Last Update: 1900-01-01