[1]黄永亮)△,李恩),汪涛).瑞舒伐他汀对心肌梗死后大鼠心肌组织中αSMA、 TGFβ1表达的影响*[J].郑州大学学报(医学版),2015,(02):232.
 HUANG Yongliang,LI En,WANG Tao.Effects of rosuvastatin on expressions of αSMA and TGFβ1 in myocardial tissue of rats with myocardial infarction[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(02):232.
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瑞舒伐他汀对心肌梗死后大鼠心肌组织中αSMA、 TGFβ1表达的影响*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年02期
页码:
232
栏目:
应用研究
出版日期:
2015-03-20

文章信息/Info

Title:
Effects of rosuvastatin on expressions of αSMA and TGFβ1 in myocardial tissue of rats with myocardial infarction
作者:
黄永亮1)△李恩2)汪涛1)
1)郑州大学第二附属医院干部病房 郑州 4500142)郑州大学第二附属医院心内科 郑州450014
Author(s):
HUANG Yongliang1)LI En2)WANG Tao1)
1)Department of Cadres Ward, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014 2)Department of Cardiology, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
心肌梗死心肌重塑瑞舒伐他汀αSMATGFβ1大鼠
Keywords:
myocardial infarctionmyocardial remodelingrosuvastatinαSMATGFβ1rat
分类号:
R541.4
摘要:
目的:通过观察瑞舒伐他汀对心肌梗死后大鼠心肌组织中α平滑肌肌动蛋白(αSMA)和转化生长因子β1(TGFβ1)表达的影响,探讨其影响心肌重塑的机制。方法:45只SD雄性大鼠分为假手术组、心肌梗死组、干预组,每组各15只。假手术组只穿线不结扎,另外2组结扎冠状动脉左前降支建立心肌梗死模型。干预组术后给予瑞舒伐他汀钙1 mg/kg灌胃,心肌梗死组及假手术组每天以2 mL生理盐水灌胃,4周后比较各组大鼠心肌胶原容积分数、αSMA、TGFβ1 mRNA和蛋白表达水平的差异。结果:给药4周后,与心肌梗死组相比,干预组心肌胶原容积分数及αSMA、TGFβ1 mRNA和蛋白表达均降低(P均<0.05);干预组和心肌梗死组上述指标均高于假手术组(P均<0.05)。结论:瑞舒伐他汀能降低受损心肌中αSMA、TGFβ1表达水平。
Abstract:
Aim: To observe the effects of rosuvastatin on the expressions of αsmooth muscle actin(αSMA) and transforming growth factorβ1(TGFβ1) in rats after myocardial infarction and to discuss the influence mechanism of myocardial remodeling.Methods: The myocardial infarction model was induced by ligation of left anterior descending coronary artery. A total of 30 SD male rats with acute myocardial infarction were randomly divided into the myocardial infarction group and rosuvastatintreated group; another 15 rats were designed as shamoperated group. Rosuvastatintreated group was given rosuvastatin at 1 mg/kg after operation,and the other 2 groups were given 2 mL normal saline each day.Four weeks later,the collagen synthesis,αSMA,TGFβ1 expression were compared. Results: Collagen synthesis,αSMA,TGFβ1 expression were reduced in the rosuvastatintreated group compared with rats in the myocardial infarction group(P<0.05),and the 3 indexes in rosuvastatintreated group and myocardial infarction group were higher than those of the shamoperated group(P<0.05).Conclusion: Rosuvastatin could reduce the expression of αSMA and TGFβ1 in the damaged myocardial tissue.

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备注/Memo

备注/Memo:
*河南省科技攻关计划项目122102310088,132102310142
更新日期/Last Update: 1900-01-01