[1]邵世清),韦业平)#,邓丽),等.盆腔器官脱垂患者阴道壁和子宫骶、主韧带组织中神经纤维特点和VIP、NPY蛋白的表达*[J].郑州大学学报(医学版),2015,(02):252.
 SHAO Shiqing,WEI Yeping,DENG Li,et al.Expressions of VIP and NPY in vaginal wall and uterosacral and cardinal ligaments of pelvic organ prolapse patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(02):252.
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盆腔器官脱垂患者阴道壁和子宫骶、主韧带组织中神经纤维特点和VIP、NPY蛋白的表达*
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年02期
页码:
252
栏目:
应用研究
出版日期:
2015-03-20

文章信息/Info

Title:
Expressions of VIP and NPY in vaginal wall and uterosacral and cardinal ligaments of pelvic organ prolapse patients
作者:
邵世清1)韦业平2)#邓丽2)张丽滢2)刘佶2)王佳祺2)雷静霞2)
1)河南大学淮河医院妇产科 开封 4750002)广西医科大学第一附属医院妇产科 南宁 530007
Author(s):
SHAO Shiqing1)WEI Yeping2)DENG Li2)ZHANG Liying2)LIU Ji2)WANG Jiaqi2)LEI Jingxia2)
1)Department of Gynecology and Obstetrics,Huaihe Hospital,Henan University,Kaifeng 4750002)Department of Gynecology and Obstetrics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530007
关键词:
盆腔器官脱垂血管活性肠肽神经肽Y神经损伤
Keywords:
pelvic organ prolapsevasoactive intestinal peptideneuropeptide Ynerve injury
分类号:
R711
摘要:
目的:研究盆腔器官脱垂(POP)患者阴道壁及子宫骶、主韧带的组织结构特点和神经纤维损伤情况,以及血管活性肠肽(VIP)、神经肽Y(NPY)的表达与POP疾病的关系。方法:选择POP轻度患者7例、重度患者8例,另取20例非POP患者作对照。选取患者阴道前壁和子宫骶、主韧带组织,采用HE染色进行病理组织学观察,免疫组化染色检测神经纤维标记PGP9.5蛋白,血管周围VIP、NPY蛋白的表达。结果:POP轻、重度组患者产次均高于对照组(F=12.196,P<0.001)。POP患者阴道壁及子宫骶、主韧带组织结构薄弱,神经纤维萎缩。3组神经纤维密度比较差异无统计学意义(P>0.05)。3组阴道壁及子宫骶、主韧带组织中血管周围VIP、NPY蛋白的表达差异有统计学意义(F=17.312、19.825、18.312、16.327、20.721、22.625,P<0.05),POP组高于对照组,POP重度组高于轻度组。结论:产次可能是POP发生的高危因素。POP患者阴道壁,子宫骶、主韧带组织中神经纤维萎缩。VIP、NPY在POP的发生、发展中起重要作用。
Abstract:
Aim: To research the nerve fiber damage and vasoactive intestinal peptide (VIP),neuropeptide Y(NPY) expression in vaginal wall, uterosacral and cardinal ligaments of patients with pelvic organ prolapsed(POP),and to investigate their relation with occurrence of POP. Methods: A total of 15 patients with POP were allocated into three groups:mild POP group(7 patients),severe POP group(8 patients),and 20 patients without POP as the control.The uterosacral, cardinal ligament and anterior vaginal tissues were obtained. HE staining and immunohistochemical staining were applied to observe the histological structure,the density of nerve fiber bundles and the expressions of VIP and NPY proteins around vascular. Results: There was significant difference in parity among the three groups and the parity of patients in POP groups were higher(F=12.196,P<0.001).The structure of vaginal wall, uterosacral and cardinal ligaments in patients with POP were weak. The expressions of perivascular VIP and NPY proteins of vaginal wall,uterosacral and cardinal ligaments among the three groups were significantly different(F=17.312,19.825,18.312,16.327,20.721,22.625,P<0.05),and which were higher in POP groups than those in control group,and were higher in severe POP group than those in the mild POP group.Conclusion: Parity maybe a risk factor for the occurrence of POP. VIP and NPY may play important roles in occurrence and development of POP.

参考文献/References:

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备注/Memo

备注/Memo:
*广西壮族自治区科技厅基金支持项目桂科攻10124001A46
更新日期/Last Update: 1900-01-01