[1]张晋东,杨海波#,赵晓燕,等.急性冠脉综合征患者血清降钙素原、D二聚体水平测定[J].郑州大学学报(医学版),2015,(02):267.
 ZHANG Jindong,YANG Haibo,ZHAO Xiaoyan,et al.Determination of serum procalcitonin and Ddimer in patients with acute coronary syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(02):267.
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急性冠脉综合征患者血清降钙素原、D二聚体水平测定
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年02期
页码:
267
栏目:
应用研究
出版日期:
2015-03-20

文章信息/Info

Title:
Determination of serum procalcitonin and Ddimer in patients with acute coronary syndrome
作者:
张晋东杨海波#赵晓燕赵荫涛王小芳李凌
郑州大学第一附属医院心内科 郑州 450052
Author(s):
ZHANG JindongYANG HaiboZHAO XiaoyanZHAO YintaoWANG XiaofangLI Ling
Department of Cardiology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
降钙素原D二聚体急性冠状动脉综合征
Keywords:
procalcitoninDdimeracute coronary syndrome
分类号:
R543.3
摘要:
目的:检测急性冠脉综合征(ACS)患者血清降钙素原、D二聚体水平,探讨二者与ACS患者冠状动脉病变程度的关系。方法:根据病情严重程度将因ACS入院的患者分为不稳定型心绞痛组(UAP组,72例)、急性心肌梗死组(AMI组,30例),另选取同期行冠状动脉造影、结果正常的20例患者作为对照组。采用ELISA法测定血清降钙素原、D二聚体水平。分析血清降钙素原、D二聚体水平与病变支数、Gensini积分的关系。结果:AMI组血清降钙素原、D二聚体水平高于UAP组及对照组(F=3.298、5.082,P<0.05),UAP组与对照组血清降钙素原、D二聚体水平差异无统计学意义(P>0.05)。UAP组血清降钙素原、D二聚体水平与Gensini积分无关(P>0.05),AMI组血清D二聚体水平与Gensini积分呈正相关(r=0.523,P<0.05)。结论:ACS患者血清降钙素原水平与冠状动脉内的炎症反应及斑块的稳定性有关,而D二聚体水平与冠状动脉狭窄的严重程度有关。
Abstract:
Aim: To determine the serum levels of procalcitonin and Ddimer in patients with acute coronary syndrome (ACS) and investigate the association between ACS and the 2 parameters. Methods: All patients with ACS were classified into unstable angina pectoris(UAP)group(n=72) and acute myocardial infarction(AMI) group(n=30),and individuals without coronary heart disease were chosen as the control group(n=20).Serum procalcitonin and Ddimer levels were measured by ELISA. The correlations between serum procalcitonin, Ddimer levels and the numbers of impaired coronary arteries,Gensini scores of coronary stenosis were analyzed respectively. Results: The levels of serum procalcitonin and Ddimer in AMI group were significantly higher than those in UAP group and control group(F=3.298 and 5.082,P<0.05), and there was no significant difference between UAP group and control group. There was positive correlation between the Ddimer level and Gensini scores in the AMI group(r=0.523,P<0.05),while there were no correlations between the levels of procalcitonin or Ddimer with Gensini scores in the UAP group(P>0.05). Conclusion: In patients with ACS, the level of serum procalcitonin correlates with the inflammatory response of coronary artery and the stability of plaques, and serum Ddimer level relates to the stenosis severity of coronary artery.

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更新日期/Last Update: 1900-01-01