[1]李伟芳),王鹏)#,李华),等.糖尿病合并非酒精性脂肪肝的危险因素分析[J].郑州大学学报(医学版),2015,(02):280.
 LI Weifang,WANG Peng,LI Hua,et al.Risk factor analysis of type 2 diabetes mellitus with nonalcoholic fatty liver disease[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(02):280.
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糖尿病合并非酒精性脂肪肝的危险因素分析
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年02期
页码:
280
栏目:
应用研究
出版日期:
2015-03-20

文章信息/Info

Title:
Risk factor analysis of type 2 diabetes mellitus with nonalcoholic fatty liver disease
作者:
李伟芳1)王鹏2)#李华1)陈素芳1)李天艺1)
1)郑州大学第一附属医院老年内分泌科 郑州 4500522)郑州大学公共卫生学院流行病学教研室 郑州 450001
Author(s):
LI Weifang1)WANG Peng2)LI Hua1)CHEN Sufang1)LI Tianyi1)
1)Department of Geriatric Endocrinology, the First Affiliated Hospital,Zhengzhou University, Zhengzhou 4500522)Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001
关键词:
2型糖尿病非酒精性脂肪肝危险因素
Keywords:
type 2 diabetes mellitusnonalcoholic fatty liver diseaserisk factor
分类号:
R587.1
摘要:
目的:探讨2型糖尿病合并非酒精性脂肪肝(NAFLD)的危险因素。方法:回顾性分析104例2型糖尿病合并NAFLD患者和157例未合并NAFLD糖尿病患者性别、年龄、糖尿病家族史、高血压病史、吸烟史、体重指数(BMI)、血尿酸、谷丙转氨酶、谷草转氨酶、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、超敏C反应蛋白、血浆凝血酶原时间(PT)、糖化血红蛋白(HBA1C)、空腹血糖(FPG)的差异。非条件logistic回归模型进行2型糖尿病合并NAFLD的危险因素分析。 结果:2组年龄、BMI、HBA1C、FPG、TG差异有统计学意义(χ2=7.266、66.897、8.911、9.348、30.161,P<0.05);Logistic回归模型分析结果显示肥胖、高TG是2型糖尿病合并NAFLD的危险因素[OR(95%CI)=4.503(2.930~6.919),1.563(1.154~2.117)]。 结论:肥胖和高TG是2型糖尿病合并NAFLD的危险因素。
Abstract:
Aim: To investigate the risk factors of type 2 diabetes mellitus with nonalcoholic fatty liver disease(NAFLD).Methods: A total of 261 cases of type 2 mellitus diabetes were collected and allocated into 2 groups according to with or without NAFLD. The risk factors of type 2 mellitus diabetes with NAFLD were analyzed by using logistic regression analysis.Results: The analysis of univariate factor showed that age,BMI,HBA1C,FPG,TG had statistical significance between the 2 groups(χ2=7.266,66.897,8.911,9.348,30.161,P<0.05). Logistic regression analysis demonstrated that obesity and increased TG are dangerous factors of type 2 diabetes mellitus with NAFLD[OR(95%CI)=4.503(2.930-6.919),1.563(1.154-2.117)].Conclusion: Obesity and high level of TG are dangerous factor of type 2 diabetes mellitus with NAFLD.

参考文献/References:

[1]中华医学会肝病学分会脂肪肝和酒精性肝病学组.非酒精性脂肪性肝病诊疗指南[J].柳州医学,2011,18(2):118 [2]Milic S,Stimac D.Nonalcoholic fatty liver disease/steatohepatitis: epidemiology, pathogenesis, clinical presentation and treatment[J].Dig Dis,2012,30(2):158 [3]Day CP.Nonalcoholic fatty liver disease: current concepts and management strategies[J].Clin Med,2006,6(1):19 [4]Angulo P.Nonalcoholic fatty liver disease[J].N Engl J Med,2002,346(16):1221 [5]Mccullough AJ.Pathophysiology of nonalcoholic steatohepatitis[J].J Clin Gastroenterol,2006,40(Suppl 1):S17 [6]Marchesini G,Marzocchi R,AgostiniF,et al.Nonalcoholic fatty liver diseaseand the metabolic syndrome[J].Curr Opin Lipidol,2005,16(4):421 [7]刘艳,张振,陈容平,等.沙格列汀对脂肪肝合并糖尿病大鼠的治疗作用[J].南方医科大学学报,2014,34(6):862 [8]Leite NC,Salles GF,Araujo AL,et al.Prevalence and associatedfactors of nonalcoholic fatty liver disease in pafients with type 2 diabetesmellitus[J].Liver Int,2009,29(1):113 [9]王凯军,苏湖梅.2型糖尿病患者非酒精性脂肪肝的临床及代谢特点分析[J].中国医师杂志,2012,14(2):212 [10]Saadeh S.Nonalcoholic fatty liver disease and obesity[J].Nutr Clin Pract,2007,22(1):1

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更新日期/Last Update: 1900-01-01