参考文献/References:
[1]张思维,张敏,李光琳,等.2003~2007年中国食管癌发病与死亡分析[J].中国肿瘤,2012,21(4):241$
[2]赫捷,邵康.中国食管癌流行病学现状、诊疗现状及未来对策[J].中国癌症杂志,2011,21(7):501$
[3]时粒笠,钟德胜,古春萍,等.塞来昔布拮抗卡铂在食管癌细胞的细胞毒作用[J].南方医科大学学报, 2014,34(6):792$
[4]Du Y,Zheng H,Wang J,et al.Metformin inhibits histone H2B monoubiquitination and downstream gene transcription in human breast cancer cells[J].Oncol Lett,2014,8(2):809$[5]Zaafar DK,Zaitone SA,Moustafa YM.Role of metformin in suppressing 1,2dimethylhydrazineinduced colon cancer in diabetic and nondiabetic mice: effect on tumor angiogenesis and cell proliferation[J].PLoS One,2014,9(6):e100562$
[6]Miyoshi H,Kato K,Iwama H,et al.Effect of the antidiabetic drug metformin in hepatocellular carcinoma in vitro and in vivo[J].Int J Oncol,2014,45(1):322$
[7]Kobayashi M,Kato K,Iwama H,et al.Antitumor effect of metformin in esophageal cancer: in vitro study[J].Int J Oncol,2013,42(2):517$
[8]Zarogoulidis P,Lampaki S,Turner JF,et al.mTOR pathway:a current, uptodate minireview (review)[J].Oncol Lett,2014,8(6):2367$
[9]张菊新,李丹丹,邹玲.子宫内膜腺癌组织中pmTOR和p4EBP1蛋白的表达[J].郑州大学学报:医学版,2010,45(1):168$
[10]鲁照明,杨帅,周媛媛,等.雷帕霉素对p70S6KsiRNA转染的 EC9706细胞增殖的影响[J].郑州大学学报:医学版,2013,48(6):717$
[11]Lee MS,Hsu CC,Wahlqvist ML,et al.Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals[J].BMC Cancer,2011,11:20$
[12]Noto H,Goto A,Tsujimoto T,et al.Cancer risk in diabetic patients treated with metformin: a systematic review and metaanalysis[J].PLoS One,2012,7(3):e33411$
[13]Skinner HD,Mccurdy MR,Echeverria AE,et al.Metformin use and improved response to therapy in esophageal adenocarcinoma[J].Acta Oncol,2013,52(5):1002$
[14]Zhao L,Wen ZH,Jia CH,et al.Metformin induces G1 cell cycle arrest and inhibits cell proliferation in nasopharyngeal carcinoma cells[J].Anat Rec(Hoboken),2011,294(8):1337$
[15]Gallagher EJ, Leroith D. Diabetes, cancer, and metformin: connections of metabolism and cell proliferation[J]. Ann N Y Acad Sci,2011,1243:54$
[16]Ji J,Zheng PS.Activation of mTOR signaling pathway contributes to survival of cervical cancer cells[J].Gynecol Oncol,2010,117(1):103$
[17]Hay N,Sonenberg N.Upstream and downstream of mTOR[J].Genes Dev,2004,18(16):1926$
[18]Faubert B,Vincent EE,Griss T,et al.Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF1α[J].Proc Natl Acad Sci U S A,2014,111(7):2554$
[19]Zhao Y,Pang TY,Wang Y,et al.LMP1 stimulates the transcription of eIF4E to promote the proliferation, migration and invasion of human nasopharyngeal carcinoma[J].FEBS J,2014,281(13):3004$
[20]Cope CL,Gilley R,Balmanno K,et al.Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain capdependent translation[J].J Cell Sci,2014,127(Pt 4):788$
[21]Faivre S,Kroemer G,Raymond E.Current development of mTOR inhibitors as anticancer agents[J].Nat Rev Drug Discov,2006,5(8):671$
[22]Armengol G,Rojo F,Castellví J,et al.4Ebinding protein 1: a key molecular "funnel factor" in human cancer with clinical implications[J].Cancer Res,2007,67(16):7551$
[23]Coleman LJ,Peter MB,Teall TJ,et al.Combined analysis of eIF4E and 4Ebinding protein expression predicts breast cancer survival and estimates eIF4E activity[J].Br J Cancer,2009,100(9):1393$
[24]No JH,Jeon YT,Park IA,et al.Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer[J].Gynecol Oncol,2011,121(1):8$
[25]Morita M,Ler LW,Fabian MR,et al.A novel 4EHPGIGYF2 translational repressor complex is essential for mammalian development[J].Mol Cell Biol,2012,32(17):3585$
[26]Mccubrey JA,Steelman LS,Kempf CR,et al.Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways[J].J Cell Physiol,2011,226(11):2762$
[27]Zhou HY,Huang SL.Current development of the second generation of mTOR inhibitors as anticancer agents[J].Chin J Cancer,2012,31(1):8$
[28]Jin HO,Hong SE,Woo SH,et al.Silencing of Twist1 sensitizes NSCLC cells to cisplatin via AMPKactivated mTOR inhibition[J].Cell Death Dis,2012,3:e319
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