[1]李媛媛,张程达,郗园林,等.HIV/HCV合并感染者的生物学特征与生存分析*[J].郑州大学学报(医学版),2015,(03):371-374.
 LI Yuanyuan,ZHANG Chengda,XI Yuanlin,et al.Biological characteristics and survival analysis in HIV/HCV coinfected patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(03):371-374.
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HIV/HCV合并感染者的生物学特征与生存分析*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年03期
页码:
371-374
栏目:
应用研究
出版日期:
2015-05-20

文章信息/Info

Title:
Biological characteristics and survival analysis in HIV/HCV coinfected patients
作者:
李媛媛1张程达2郗园林1鲁凤民3沈弢3张卫东1
1郑州大学公共卫生学院流行病学教研室 郑州 4500012中国医学科学院北京协和医学院 北京 1007303北京大学医学部基础医学院病原生物学系 北京 100191
Author(s):
LI Yuanyuan1ZHANG Chengda2XI Yuanlin1LU Fengmin3SHEN Tao3ZHANG Weidong1
1Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 4500012 Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 1007303 Department of Pathogenic Biology, School of Basic Medical Sciences,Health Science Center, Peking University, Beijing 100191
关键词:
丙型肝炎病毒人类免疫缺陷病毒混合感染队列研究
Keywords:
hepatitis C virushuman immunodeficiency viruscoinfectioncohort study
分类号:
R512.91
文献标志码:
A
摘要:
目的:了解HIV/HCV合并感染者、单纯HIV感染者的肝脏受损状况、肝脏功能指标以及生存状况。方法:对河南省某地有偿献血所致的HIV/HCV合并感染组144人和单纯HIV感染组60人进行回顾性队列研究,记录其生存情况,进行CD4+和CD8+T淋巴细胞计数以及肝功能各项指标检查,B超检查肝脏纤维化情况。结果:HIV/HCV合并感染组的生存时间为21.998(20.960~23.036) a,单纯HIV感染组的生存时间为24.904(23.555~26.253) a,两组生存曲线差异具有统计学意义(χ2=6.183, P=0.013)。两组CD4+、CD8+T淋巴细胞计数差异无统计学意义(Z=1.019和0.121, P>0.05)。HIV/HCV合并感染组的肝脏纤维化率以及ALT、AST、PT异常升高的比例高于单纯HIV感染组(χ2=6.410、4.123、4.312和4.040,P<0.05)。 结论:HIV可以促进HIV/HCV合并感者肝脏的纤维化进程。
Abstract:
To analyse liver damage situation, biochemical parameters and survival condition of HIV/HCV coinfected people and only HIV infected people.Methods: A total of 144 patients in HIV/HCV coinfection group and 60 patients in HIV infection group who were paid blood donors in Henan Province were studied through retrospective cohorts and followedup for survival quality. The blood samples were collected for determining CD4+,CD8+T cell counts and biochemical parameters, and ultrasonic examination was performed for liver fibrosis detection.Results: The survival time of HIV/HCV coinfected people was 21.998(20.960-23.036) years, and the survival time of HIV infected people was 24.904(23.555-26.253) years,and there was statistical difference between the two groups(χ2=6.183,P=0.013).After HAART, the CD4+ and CD8+T cell counts between the 2 groups had no significant difference(Z=1.019,0.121, P>0.05). However, the incidence of liver fibrosis and the levels of ALT,AST,TP in HIV/HCV coinfection group was higher than those of HIV infection group(χ2=6.410,4.123,4.312,4.040,P<0.05).Conclusion: Compared with single HIV infected people, HIV/HCV coinfection might accelerate the progression of the liver fibrosis.

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备注/Memo

备注/Memo:
通信作者,男,1963年10月生,博士,教授,研究方向:分子流行病学,Email:imooni@163.com
更新日期/Last Update: 1900-01-01