[1]徐丽伟,张梦真.宫颈癌和宫颈上皮内瘤变组织中成纤维活化蛋白α的表达*[J].郑州大学学报(医学版),2015,(03):375-377.
 XU Liwei,ZHANG Mengzhen.Expression of fibroblast activation protein α in cervical cancer and cervical intraepithelial neoplasia tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(03):375-377.
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宫颈癌和宫颈上皮内瘤变组织中成纤维活化蛋白α的表达*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年03期
页码:
375-377
栏目:
应用研究
出版日期:
2015-05-20

文章信息/Info

Title:
Expression of fibroblast activation protein α in cervical cancer and cervical intraepithelial neoplasia tissue
作者:
徐丽伟张梦真
郑州大学第一附属医院妇产科;河南省高等学校临床医学重点学科开放实验室 郑州 450052
Author(s):
XU LiweiZHANG Mengzhen
Department of Gynecology and Obstetrics,the First Affiliated Hospital,Zhengzhou University;KeyDisciplines Laboratory for Clinical Medicine of Henan Province, Zhengzhou 450052
关键词:
宫颈癌宫颈上皮内瘤变成纤维活化蛋白α浸润转移
Keywords:
cervical cancer cervical intraepithelial neoplasia fibroblast activation protein α invasion metastasis
分类号:
R737.33
文献标志码:
A
摘要:
目的:检测宫颈癌和宫颈上皮内瘤变(CIN)组织中成纤维活化蛋白α(FAPα)的表达情况。方法:采用免疫组化SP法检测10例宫颈炎、40例CIN及81例宫颈癌组织中FAPα的表达。结果:FAPα在宫颈炎组织中不表达,宫颈癌组织中FAPα阳性表达率高于CIN组织(χ2=81.706,P<0.001)。不同组织学类型(Z=2.069,P=0.039)、淋巴结转移情况(Z=3.382,P=0.001)和浸润深度(Z=2.185,P=0.029)的宫颈癌组织中FAPα表达水平比较,差异有统计学意义。结论:FAPα可能参与了宫颈癌的发生发展。
Abstract:
To detect the expression of fibroblast activation protein α (FAPα) in cervical cancer and cervical intraepithelial neoplasia tissue. Methods: FAPα expression in 10 cases of human cervicitis, 40 cases of cervical intraepithelial neoplasia and 81 cases of cervical cancer tissue was detected by SP method.Results: FAPα expression was higher in cervical cancer tissue than that in cervical intraepithelial neoplasia tissue(χ2 =81.706,P<0.001). FAPα expression in cervical cancer tissue was different with different histopathologic type(Z=2.069,P=0.039), lymph node metastasis(Z=3.382,P=0.001), and depth of invasion(Z=2.185,P=0.029).Conclusion: FAPα may take part in invasion and metastasis of cervical cancer.

参考文献/References:

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备注/Memo

备注/Memo:
通信作者,女,1965年2月生,博士,主任医师,研究方向:妇科肿瘤,Email:13683806877@163.com
更新日期/Last Update: 1900-01-01