[1]王芳,李红文#,郑乃刚,等.寻常型银屑病皮损组织中Nestin、NF-κBp65及STAT3蛋白的表达[J].郑州大学学报(医学版),2015,(04):522-525.
 WANG Fang,LI Hongwen,ZHENG Naigang,et al.Expressions of Nestin,NFκBp65 and STAT3 in psoriatic lesion of patients with psoriasis vulgaris[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(04):522-525.
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寻常型银屑病皮损组织中Nestin、NF-κBp65及STAT3蛋白的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年04期
页码:
522-525
栏目:
应用研究
出版日期:
2015-07-20

文章信息/Info

Title:
Expressions of Nestin,NFκBp65 and STAT3 in psoriatic lesion of patients with psoriasis vulgaris
作者:
王芳1李红文1#郑乃刚2吴景兰23
1)郑州大学第一附属医院皮肤科 郑州 4500522)郑州大学基础医学院肿瘤基础学教研室 郑州 4500013)郑州大学基础医学院分子生物学研究中心 郑州 450001
Author(s):
WANG Fang1LI Hongwen1 ZHENG Naigang2 WU Jinglan23
1)Department of Dermatology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522)Department of Oncosis Pathology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 4500013)Research Center of Molecular Cell Biology,College of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001
关键词:
NestinNFκBp65STAT3银屑病
Keywords:
NestinNFκBp65STAT3psoriasis disease
分类号:
R758.63
文献标志码:
A
摘要:
目的:比较寻常型银屑病皮损组织与正常皮肤组织中Nestin、NFκBp65和STAT3蛋白表达的差异。方法:应用免疫组化技术检测14例寻常型银屑病皮损和14例正常皮肤标本组织中Nestin、NFκBp65 和STAT3蛋白的定位及表达水平。结果:Nestin蛋白定位于表皮基底层个别干细胞的胞质内,NFκBp65和STAT3蛋白定位于表皮基底细胞和棘层细胞的胞核及胞质。寻常型银屑病皮损组织中Nestin[(167.51±12.93) vs (114.38±10.85)]、NFκBp65[(127.48±13.87) vs (101.27±10.15)]和STAT3[(196.34±10.70) vs (124.63±19.93)]蛋白的表达水平均高于正常皮肤组织,差异有统计学意义(t=12.977,6.288,13.072;P均<0.001)。寻常型银屑病患者皮损组织和正常皮肤标本组织中NFκBp65与STAT3蛋白表达均呈正相关(r=0.960和0.829,P均<0.001)。结论:寻常型银屑病皮损组织中Nestin、NFκBp65和STAT3蛋白表达水平较高,抑制它们的表达可能是治疗该病的有效手段。
Abstract:
Aim: To compare the expression levels of Nestin, NFκBp65 and STAT3 in psoriatic lesions and normal samples. Methods: Immunohistochemical technique was used to determine the expressions of Nestin, NFκBp65 and STAT3 in 14 psoriatic lesions and 14 normal samples. Results: The Nestin was located in the cytoplasm of respective stem cells in the basic cell layer, while that of NFκBp65 or STAT3 was located in nuclei and cytoplasm in some basic layer cells and prickle layer cells. The expression levels of Nestin, NFκB and STAT3 in psoriatic lesions were significantly higher than that in the normal samples[Nestin(167.51±12.93) vs (114.38±10.85),NFκBp65(127.48±13.87) vs (101.27±10.15) and STAT3(196.34±10.70) vs (124.63±19.93), t=12.977,6.288,and 13.072,all P<0.001]. There was positive correlation between NFκBp65 and STAT3 in psoriatic lesions and normal samples(r=0.960 and 0.829,P<0.001). Conclusion: The expression levels of Nestin,NFκB and STAT3 are significantly higher in psoriatic lesion, and inhibiting their expressions may be valid manipulation for treatment of psoriasis vulgaris.

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更新日期/Last Update: 1900-01-01