[1]高延秋△,张华,刘敏,等.重症肺炎患者外周血IL-6和IL-18水平的检测[J].郑州大学学报(医学版),2015,(04):555-558.
 GAO Yanqiu,ZHANG Hua,LIU Min,et al.Determination of peripheral blood IL6 and IL18 in patients with severe pneumonia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(04):555-558.
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重症肺炎患者外周血IL-6和IL-18水平的检测()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年04期
页码:
555-558
栏目:
应用研究
出版日期:
2015-07-20

文章信息/Info

Title:
Determination of peripheral blood IL6 and IL18 in patients with severe pneumonia
作者:
高延秋△张华刘敏任英杰马珊珊李双凤
郑州大学附属郑州中心医院呼吸重症医学科 郑州 450007
Author(s):
GAO YanqiuZHANG HuaLIU Min REN YingjieMA ShanshanLI Shuangfeng
Respiratory Intensive Care Unit,the Affiliated Zhengzhou Central Hospital, Zhengzhou University,Zhengzhou 450007
关键词:
重症肺炎白细胞介素6白细胞介素18
Keywords:
severe pneumoniainterleukin6interleukin18
分类号:
R563.1
文献标志码:
A
摘要:
目的:探讨重症肺炎患者外周血白细胞介素6(IL6)和IL18水平变化及其临床意义。方法:选择重症肺炎患者45例,临床肺部感染评分(CPIS)>6分15例,CPIS≤6分30例;常规治疗10 d后好转26例,恶化19例。选择同期收治的普通肺炎患者33例作为对照。重症肺炎组分别于治疗前和病程第3、7天,对照组于就诊当天抽取外周静脉血3 mL,放射免疫法测定IL6,酶联免疫吸附法测定IL18。结果:治疗前,重症肺炎组外周血IL6和IL18水平均高于对照组(t=7.672、8.376,P<0.05),CPIS高分组患者高于CPIS低分组(t=6.685、6.652,P<0.05)。治疗好转组和恶化组患者外周血IL6和IL18水平随病程进展均逐渐降低(F时间=17.921、10.533,P<0.05),好转组患者外周血IL6和IL18水平降低程度显著大于恶化组(F组间=10.186、8.276,P<0.05)。Pearson相关分析结果显示,治疗前重症肺炎患者外周血IL6与IL18水平呈显著正相关(r=0.517,P<0.001)。结论:外周血IL6和IL18水平可反映重症肺炎患者肺部感染的严重程度和预后。
Abstract:
Aim: To explore the levels of peripheral blood interleukin6(IL6) and IL18 in patients with severe pneumonia and the significance. Methods: A total of 45 patients with severe pneumonia were collected, out of which 15 cases with the clinical pulmonary infection score(CPIS)>6 and 30 cases with CPIS≤6. After 10 days treatment, 26 cases were improved and 19 cases were deteriorating. Another 33 cases of ordinary pneumonia at the same period in the hospital were the control group. Peripheral blood IL6 and IL18 levels were determined by radioimmunoassay and enzymelinked immunosorbent assay before the treatment and on the 3rd,7th day of the course of disease. Results: The peripheral blood IL6 and IL18 levels in severe pneumonia group before treatment were higher than those in the control group(t=7.672,8.376,P<0.05). The peripheral blood IL6 and IL18 levels in high CPIS group were higher than those in low CPIS group before treatment(t=6.685,6.652,P<0.05).The peripheral blood IL6 and IL18 levels in the improved group and deteriorating group gradually declined with time(Ftime=17.921,10.533,P<0.05),and the peripheral blood IL6 and IL18 levels and the decreased magnitude in the improved group were greater than those of the deteriorating group(Fgroup=10.186,8.276,P<0.05).Pearson correlation analysis showed that the peripheral blood IL6 level was positively correlated with IL18(r=0.517,P<0.001) in severe pneumonia group before treatment.Conclusion: Peripheral blood IL6 and IL18 could reflect the severity of lung infection and prognosis of severe pneumonia patients.

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更新日期/Last Update: 1900-01-01