[1]杨晓村),王 颖)#,燕树勋),等.肾血管性高血压大鼠肾组织睾酮受体蛋白及丝裂素活化蛋白激酶磷酸酶1的表达[J].郑州大学学报(医学版),2015,(05):614-617.
 YANG Xiaocun)),WANG Ying)),YAN Shuxun),et al.Expressions of androgen receptor and mitogen-activated protein kinase phosphatase-1 in rats with renovascular hypertension[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(05):614-617.
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肾血管性高血压大鼠肾组织睾酮受体蛋白及丝裂素活化蛋白激酶磷酸酶1的表达()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年05期
页码:
614-617
栏目:
论著
出版日期:
2015-09-20

文章信息/Info

Title:
Expressions of androgen receptor and mitogen-activated protein kinase phosphatase-1 in rats with renovascular hypertension
作者:
杨晓村12)王 颖12)#燕树勋3)杨国杰12)张彦周24)于超男12)李 渊12)孙丽娜12)
1)郑州大学第一附属医院老年医学科 郑州 450052 2)河南省高等学校临床医学重点学科开放实验室 郑州 450052 3)河南中医学院第一附属医院内分泌科 郑州 450008 4)郑州大学第一附属医院心内科 郑州 450052
Author(s):
YANG Xiaocun1)2) WANG Ying1)2) YAN Shuxun3) YANG Guojie1)2) ZHANG Yanzhou2)4) YU Chaonan1)2) LI Yuan1)2) SUN Lina1)2)
1)Department of Geriatrics, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052 2)Key-Disciplines Laboratory of Clinical-Medicine of Henan,Zhengzhou 450052 3)Department of Endocrinology and Metabolism, the First Affiliated Hospital,Henan College of Traditional Chinese Medicine, Zhengzhou 450008 4)Department of Cardiology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
肾血管性高血压 睾酮受体 丝裂素活化蛋白激酶磷酸酶1 大鼠
Keywords:
renovascular hypertension androgen receptor mitogen-activated protein kinase phosphatase-1 rat
分类号:
R544.1+4
文献标志码:
A
摘要:
目的:探讨睾酮受体(AR)在高血压肾脏损害中的作用并初步探讨其机制。方法:30只大鼠分为对照组、假手术组和模型组,每组10只; 模型组以“两肾一夹法”建立肾血管性高血压大鼠模型。采用免疫组化法检测大鼠肾组织AR和丝裂素活化蛋白激酶磷酸酶1(MKP-1)蛋白的表达。结果:与对照组相比,模型组大鼠肾组织AR与MKP-1蛋白的表达水平降低(F=31.043、51.681,P<0.001); 相关分析发现,模型组大鼠肾组织中AR蛋白与MKP-1蛋白的表达呈正相关(r=0.744,P=0.014)。结论:AR蛋白可能参与了高血压肾脏损害的过程,其机制可能与AR和MKP-1信号转导通路偶联有关。
Abstract:
Aim: To explore the role of androgen receptor(AR)in injury of hypertensive kidney and explore the mechanism.Methods: Thirty rats were allocated into 3 groups: control group, sham operation group and model group, with 10 rats in each group; the rats in model group were made renovascular hypertension model. The expressions of AR and mitogen-activated protein kinase phosphatase-1(MKP-1)were detected by immunohistochemistry.Results: In contrast with control group, the protein expression levels of AR and MKP-1 in model group were significantly reduced(F=31.043,51.681,P<0.001). Linear correlation analysis showed there was positive correlation between the expression level of AR protein and that of MKP-1 protein in the model group(r=0.744,P=0.014).Conclusion: AR may participate in the hypertensive renal injury,which may be explained by MKP-1 signaling pathway that couples with AR.

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更新日期/Last Update: 1900-01-01