[1]朱娟芳),田雪丽),杨文丽),等.兔骨内激光快速成型纯钛的植入[J].郑州大学学报(医学版),2015,(05):658-661.
 ZHU Juanfang),TIAN Xueli),YANG Wenli),et al.Biocompatibility of laser rapid forming Ti in bone of rabbits[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(05):658-661.
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兔骨内激光快速成型纯钛的植入()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年05期
页码:
658-661
栏目:
应用研究
出版日期:
2015-09-20

文章信息/Info

Title:
Biocompatibility of laser rapid forming Ti in bone of rabbits
作者:
朱娟芳1)田雪丽1)杨文丽1)田丽萍1)陈 静2)高 勃3)#
1)郑州大学第一附属医院口腔医学中心 郑州 4500522)西北工业大学凝固技术国家重点实验室 西安 7100723)第四军医大学口腔医院修复科 西安 710032
Author(s):
ZHU Juanfang1)TIAN Xueli1)YANG Wenli1)TIAN Liping1)CHEN Jing2)GAO Bo3)
1)Stomatology Center,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 4500522)State Key Laboratory of Solidification Processing,Northwestern Polytechnical University,Xi'an 7100723)Department of Prosthodontics,College of Stomatology,the Fourth Military Medical University,Xi'an 710032
关键词:
激光快速成型 生物相容性
Keywords:
titanium laser rapid forming biocompatibility rabbit
分类号:
R783.6
文献标志码:
A
摘要:
目的:研究激光快速成型(LRF)纯钛(Ti)的生物相容性。方法:将LRF Ti机加工成圆柱状试样(A型):直径2 mm,高6 mm; 圆柱状加帽试样(B型):直径2 mm,高6 mm,帽直径4 mm、高2 mm,沿帽直径方向打一直径1 mm的孔。将工业Ti(CP Ti)加工成同样规格的试样作对照。试样植入动物股骨4周后,对组织标本进行X射线、病理组织学、扫描电镜观察和生物结合力测试。结果:LRF Ti和CP Ti种植体周围软组织均无红肿等炎症反应,种植体均无松动; 种植体周围骨组织连续,无骨吸收现象,骨组织与种植体接触紧密。LRF Ti种植体骨界面愈合形式与CP Ti种植体完全相同,组织排列正常。扫描电镜下可见种植体与骨组织界面之间有骨细胞突和骨胶原纤维,在骨松质区,可见成纤维细胞和成骨细胞突、骨小梁伸向氧化膜的表面。LRF Ti的种植体界面的剪切力为(31.94±5.48)N,CP Ti为(30.63±4.26)N,两者之间差异无统计学(t=0.469,P=0.651)。结论:LRF Ti具有良好的骨组织相容性,能够形成良好的骨结合。
Abstract:
Aim: To measure the biocompatibility of laser rapid forming(LRF)pure titanium(Ti).Methods: LRF Ti machined into cylindrical specimens(type A)with the diameter of 2 mm and height of 6 mm and cylindrical capped specimen(type B)with the diameter of 2 mm and height of 6 mm(part of the cap was 4 mm in diameter and 2 mm in height, and a hole with a diameter of 1 mm along diameter direction). Commercial pure titanium(CP Ti)as control. After 4 weeks of implantation, X rays, and the histological and scanning electron microscope were used to observe the structure of the specimens,and biological binding force was tested.Results: There was no swelling and other inflammatory reaction around the implant of LRF Ti and CP Ti, and no implant was loose. Bone tissue around the implant was continuous. Implant and bone tissue were closely linked. LRF Ti implant interface healing was in the same form as CP Ti,the organization was normal. Under a scanning electron microscope,bone cells and collagen fiber were observed between implant and bone; The fibroblasts and osteoblasts were seen in the cancellous bone,bone trabecula extends to the film surface. The implant interfacial shear force of Ti LRF and the Ti CP were(31.94±5.48)N and(30.63±4.26)N,respectively, and there were no significant differences(t=0.469,P=0.651).Conclusion: LRF Ti has good biocompatibility,which can form a good bone bonding.

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更新日期/Last Update: 1900-01-01