[1]薄亚聪),姚明解),张 玲),等.术前血液生化指标与原发性肝细胞癌预后的关系[J].郑州大学学报(医学版),2015,(05):662-664.
 BO Yacong),YAO Mingjie),ZHANG Ling),et al.Relationship between preoperative blood biochemical indexes and prognosis of primary hepatocellular carcinoma patients[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(05):662-664.
点击复制

术前血液生化指标与原发性肝细胞癌预后的关系()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年05期
页码:
662-664
栏目:
应用研究
出版日期:
2015-09-20

文章信息/Info

Title:
Relationship between preoperative blood biochemical indexes and prognosis of primary hepatocellular carcinoma patients
作者:
薄亚聪1)姚明解2)张 玲3)陆维权4)高 强1)吕全军1)#
1)郑州大学公共卫生学院营养与食品卫生学教研室 郑州 450001 2)北京大学基础医学院病原生物学系 北京 100191 3)郑州大学附属肿瘤医院; 河南省肿瘤医院肝胆外科 郑州 450003 4)河南省肿瘤研究院卫生统计学室 郑州 450003
Author(s):
BO Yacong1) YAO Mingjie2) ZHANG Ling3) LU Weiquan4) GAO Qiang1) LV Quanjun1)
1)Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001 2)Department of Pathogenic Biology, School of Basic Medical Sciences, Peking University, Beijing 100191 3)Department of Hepatobiliary Surgery, the Affiliated Tumor Hospital; Henan Tumor Hospital,Zhengzhou University, Zhengzhou 450003 4)Department of Health Statistics, Henan Tumor Institute, Zhengzhou 450003
关键词:
原发性肝细胞癌 术后生存时间 血液生化指标
Keywords:
primary hepatocellular carcinoma postoperative survival time blood biochemical index
分类号:
R735.7
文献标志码:
A
摘要:
目的:探讨血清门冬氨酸氨基转移酶(AST)、谷氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、总胆红素、白蛋白(ALB)、甲胎蛋白(AFP)等术前血液生化指标对经手术治疗的原发性肝细胞癌(HCC)患者术后生存时间的影响,为HCC患者的手术预后判断提供依据。方法:收集接受手术的原发性HCC患者500例,对其进行随访观察,采用Kaplan-Meier法和Log-rank检验进行生存分析,将生存分析中有意义的因素引入Cox回归模型。结果:AFP、AST、ALP、ALB是影响经手术治疗的HCC患者术后生存时间的独立危险因素[RR(95%CI)分别为1.779(1.330~2.308)、1.391(1.049~1.843)、2.063(1.497~2.844)、0.636(0.493~0.821)]。结论:术前检测AFP、AST、ALP、ALB对原发性HCC患者手术预后判断具有重要价值。
Abstract:
Aim: To investigate the value of aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP), total bilirubin, albumin(ALB), alpha fetoprotein(AFP)and other biochemical indexes of blood in predicting postsurgical survival time of the patients with primary hepatocellular carcinoma(HCC), and provide basis for surgeons' clinical treatment.Methods: A total of 500 patients with primary HCC underwent hepatectomy were followed up. Survival analysis was carried out using Kaplan-Meier method and Log-rank test. The multivariate analysis was conducted using Cox proportional hazard model.Results: AFP,AST,ALP,and ALB were independent risk factors for survival time of the patients with primary HCC[RR(95%CI)=1.779(1.330-2.308),1.391(1.049-1.843),2.063(1.497-2.844), and 0.636(0.493-0.821)].Conclusion: AFP,AST,ALP,and ALB could be used as prognostic indexes for patients with primary HCC before operation.

参考文献/References:

[1] Parkin DM,Bray F,Ferlay J,et al.Global cancer statistics, 2002[J].CA Cancer J Clin,2005,55(2):74
[2] Poon RT,Fan ST,Ng IO,et al.Significance of resection margin in hepatectomy for hepatocellular carcinoma:A critical reappraisal[J].Ann Surg,2000,231(4):544
[3] 赵素容,张媛媛,吴成柱,等.3-溴丙酮酸增强肝癌细胞对顺铂敏感性的作用[J].南方医科大学学报,2014,34(1):25
[4] 中华人民共和国卫生部.原发性肝癌诊疗规范:2011年版[J].临床肝胆病杂志,2011,27(11):1141
[5] Jemal A,Bray F,Center MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69
[6] Lee HJ,Kang IW,Won SY,et al.Description of a novel anatomic venous structure in the nasoglabellar area[J].J Craniofac Surg,2014,25(2):633
[7] 阎涛,毕新宇,方仪,等.肝细胞肝癌术后预后因素分析[J].实用肿瘤杂志,2011,26(4):337
[8] 李甸源,高松涛,石永刚,等.原发性肝癌96例三维适形放疗疗效分析[J].郑州大学学报:医学版,2009,44(5):1075
[9] 王嘉毅.原发性肝癌组织EGFR和MMP9表达与术后复发或转移的关系[J].郑州大学学报:医学版,2005,40(5):885
[10]孙万日.影响肝细胞肝癌切除术预后的多因素分析[D].郑州:郑州大学,2007.
[11]李松朋,吴力群.术前甲胎蛋白水平对原发性肝细胞癌RO切除术后早期复发的影响[J].中华外科杂志,2013,51(7):600
[12]李志强.原发性肝细胞癌行肝切除术后复发的预后因素分析[J].中国医药科学,2011,1(18):22
[13]徐成,李敬东,石刚,等.原发性肝细胞癌行根治性肝切除术后复发的预后因素分析[J].中华外科杂志,2010,48(11):806
[14]钟锐,张俊.肝功能指标在原发性肝癌中的诊断价值[J].中国现代医学杂志,2015,25(8):102
[15]Yen YH,Changchien CS,Wang JH,et al.A modified TNM-based Japan Integrated Score combined with AFP level may serve as a better staging system for early-stage predominant hepatocellular carcinoma patients[J].Dig Liver Dis,2009,41(6):431
[16]李立青,史蓉华,王晓玲,等.PA、ALB、TBIL、TBA和CHE在肝脏疾病诊断中的应用价值[J].标记免疫分析与临床,2010,17(6):394

相似文献/References:

[1]翟倩倩),岳素文),张玲),等.原发性肝癌组织中SOX7 mRNA的表达*[J].郑州大学学报(医学版),2011,(03):354.
 ZHAI Qianqian),YUE Suwen),ZHANG Ling),et al.Expression of SOX7 mRNA in parimay hepatocellular carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2011,(05):354.
[2]岳素文,翟倩倩,张玲,等.人原发性肝细胞癌细胞和组织中SOX2 mRNA的表达*[J].郑州大学学报(医学版),2011,(04):611.
[3]许亚坡,周琳,王春峰,等.原发性肝细胞癌组织中血管紧张素转化酶Ⅱ与血管紧张素Ⅱ1型受体的表达*[J].郑州大学学报(医学版),2013,(05):613.
 XU Yapo,ZHOU Lin,WANG Chunfeng,et al.Expressions of angiotensin converting enzyme Ⅱ and angiotensin Ⅱ type 1 receptor in primary hepatocellular carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2013,(05):613.

更新日期/Last Update: 1900-01-01