YANG Xianhui,LV Miaomiao,FU Hongguang,et al.Influence of propofol combined with dexmedetomidine on intraoperative awareness and postoperative memory[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(05):692-696.





Influence of propofol combined with dexmedetomidine on intraoperative awareness and postoperative memory
郑州大学第二附属医院麻醉科 郑州 450014
YANG Xianhui LV Miaomiao FU Hongguang DONG Tieli
Department of Anesthesiology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014
右美托咪定 异丙酚 靶控输注 脑电双频指数 大脑状态指数
dexmedetomidine propofol target controlled infusion bispectral index cerebral state index
Aim: To investigate the influence of propofol combined with dexmedetomidine on intraoperative awareness and postoperative memory.Methods: A total of 120 patients waiting for general anesthesia before surgery were allocated into observation groups(A, B, C)and control groups(A0, B0, C0). Target controlled infusion(TCI)of propofol was performed in advance, then dexmedetomidine infusion for the observation group and normal saline infusion for the control group were carried out, respectively. Bispectral index(BIS)and cerebral state index(CSI)values during the study were observed and recorded, as well as changes in hemodynamic indexes, and the intraoperative awareness and postoperative memory were recorded.Results: After induction of anesthesia and intubation, the fH and pMA of the observation group at different time points were lower than that of the control group(P<0.05). CI in the control group decreased significantly, while that in the observation group had no significant changes. After intubation, the pCV of the observation group was significantly higher than that of the control group(P<0.05).The values of BIS and CSI for all patients at T2 had statistical differences(P<0.05).After being given dexmedetomidine, BIS and CSI of the patients in group A and B at T3 decreased compared with those in the control group(P<0.05).BIS values for patients in group C at each time point did not change significantly compared with that in control group, while the CSI values were still declining(P<0.05). Except for the patients in group A and A0, all the other patients did not had memories of intraoperative events and related dreams.Conclusion: Propofol combined with dexmedetomidine has better enhancement effect compared with propofol TCI alone in general anesthesia,and the intraoperative awareness and postoperative memory reduced,which could avoid the occurrence of postoperative anxiety and other psychological complications.


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更新日期/Last Update: 1900-01-01