[1]孙逸杰,景戈翰,杨菁,等.TFAM基因rs10826178与rs4390300两多态位点与精神分裂症的关系[J].郑州大学学报(医学版),2015,(06):773-776.
 SUN Yijie,JING Gehan,YANG Jing,et al.Relationship of TFAM gene′s two polymorphic loci rs10826178 and rs4390300 with schizophrenia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(06):773-776.
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TFAM基因rs10826178与rs4390300两多态位点与精神分裂症的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年06期
页码:
773-776
栏目:
论著
出版日期:
2015-12-20

文章信息/Info

Title:
Relationship of TFAM gene′s two polymorphic loci rs10826178 and rs4390300 with schizophrenia
作者:
孙逸杰12景戈翰12杨菁12何书平3仝冬晓4王丽雯5司沛茹6金璐17程晓丽1#
1郑州大学基础医学院医学遗传与细胞生物学系 郑州 4500012郑州大学临床医学系 郑州 4500523郑州市精神病防治医院精神科 郑州 4500054郑州大学附属洛阳中心医院妇产医学部实验室 洛阳 4710005郑州大学第三附属医院筛查中心 郑州 4500526郑州大学第三附属医院检验科 郑州 4500527郑州市第四十七中学生物学教研室 郑州 451150
Author(s):
SUN Yijie12JING Gehan12YANG Jing12HE Shuping3TONG Dongxiao4WANG Liwen5SI Peiru6JIN Lu17CHENG Xiaoli1
1Department of Medical Genetics and Cell Biology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 4500012Department of Clinical Medicine, Zhengzhou University, Zhengzhou 450052 3Department of Psychiatry,Zhengzhou Mental Health Hospital,Zhengzhou 4500054Laboratory of Gynaecology and Obstetrics Medicine,the Affiliated Luoyang Central Hospital,Zhengzhou University,Luoyang 4710005Screening Center,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 450052 6Clinical Laboratory,the Third Affiliated Hospital,Zhengzhou University,Zhengzhou 4500527Department of Biology,No.47 Middle School of Zhengzhou,Zhengzhou 451150
关键词:
1)郑州大学基础医学院医学遗传与细胞生物学系 郑州 4500012)郑州大学临床医学系 郑州 4500523)郑州市精神病防治医院精神科 郑州 4500054)郑州大学附属洛阳中心医院妇产医学部实验室 洛阳 4710005)郑州大学第三附属医院筛查中心 郑州 4500526)郑州大学第三附属医院检验科 郑州 4500527)郑州市第四十七中学生物学教研室 郑州 451150
Keywords:
schizophreniapolymorphismmtDNATFAM
分类号:
R749.3
摘要:
目的:探讨线粒体转录因子A(TFAM)基因多态性与精神分裂症的关系。方法:采用PCRRFLP及DNA序列分析技术分别对237例精神分裂症患者及246例健康对照TFAM 基因rs10826178、rs4390300两多态位点进行检测及分析。结果:rs10826178与rs4390300位点等位基因与基因型频率分布在两组之间比较,差异无统计学意义(P均>0.05)。结论:TFAM基因rs4390300、rs10826178的基因型差异可能与精神分裂症的发病无关。
Abstract:
Aim: To research the relationship between mitochondrial transcription factor A(TFAM) gene′s two polymorphic loci and schizophrenia.Methods: The PCRRFLP analysis and DNA sequencing technology were used to detect polymorphism of rs10826178 and rs4390300 in 237 cases of schizophrenia(patient group) and 246 healthy subjects(control group).Results: The genotype frequencies and allele frequencies of TFAM gene rs10826178 and rs4390300 in the two groups had no differences(P>0.05).Conclusion: TFAM gene rs10826178 and rs4390300 polymorphisms may not be associated with schizophrenia.

参考文献/References:


[1]Tong D,He S,Wang L,et al.Association of singlenucleotide polymorphisms in the cannabinoid receptor 2 gene with schizophrenia in the Han Chinese population[J].J Mol Neurosci,2013,51(2):454
[2]Gatt AP,Jones EL,Francis PT,et al.Association of a polymorphism in mitochondrial transcription factor A(TFAM) with Parkinson′s disease dementia but not dementia with Lewy bodies[J].Neurosci Lett,2013,557(Pt B):177
[3]张纪亮,张宜家,王杰,等.线粒体转录因子A及其相关疾病[J].中国细胞生物学学报,2013,35(5):712
[4]姚鹏程,张佐,彭淑红,等.线粒体转录因子A的研究进展[J].生命科学,2011,30(5):454
[5]Kanki T,Ohgaki K,Gaspari M,et al.Architectural role of mitochondrial transcription factor A in maintenance of human mitochondrial DNA[J].Mol Cell Biol,2004,24(22):9823
[6]吴俊涵,刘书连,程晓丽,等.河南汉族精神分裂症患者mtDNA 5351位点突变与GRIK2基因两位点多态性检测[J].郑州大学学报:医学版,2011,46(1):71
[7]TaherzadehFard E,Carsten S,Denis AA,et al.PGC1alpha downstream transcription factors NRF1 and TFAM are genetic modifiers of Huntington disease[J].Mol Neurodegener,2011,6(1):32
[8]Belin AC,Bjrk BF,Westerlund M,et al.Association study of two genetic variants in mitochondrial transcription factor A(TFAM) in Alzheimer′s and Parkinson′s disease[J].Neurosci Lett,2007,420(3):257
[9]Hayashi Y,Yoshida M,Yamato M,et al.Reverse of agedependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice[J].J Neurosci,2008,28(34):8624
[10]Shitara H,Nishiyama S,Nakada K,et al.Therapeutic effect of Tfam overexpression in a mouse model of mitochondrial disease[J].Transgenic Res,2011,20(5):1172
[11]雷阳,齐中华,牟文松,等.FGF20基因单核苷酸多态性与帕金森病的相关性分析[J].解放军医学杂志,2014,39(2):129

更新日期/Last Update: 1900-01-01