[1]莫珩,高承志#,王少杰,等.口腔扁平苔藓患者情绪障碍与唾液皮质醇和脱氢表雄酮水平的相关性[J].郑州大学学报(医学版),2015,(06):818-822.
 MO Heng,GAO Chengzhi,WANG Shaojie,et al.Association between the mood obstacle and salivary cortisol, DHEA levels in patients with oral lichen planus[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(06):818-822.
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口腔扁平苔藓患者情绪障碍与唾液皮质醇和脱氢表雄酮水平的相关性()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年06期
页码:
818-822
栏目:
应用研究
出版日期:
2015-12-20

文章信息/Info

Title:
Association between the mood obstacle and salivary cortisol, DHEA levels in patients with oral lichen planus
作者:
莫珩1高承志1#王少杰2 曲姗3
1北京大学人民医院口腔科 北京 1000442北京大学人民医院中医科 北京 1000443北京大学人民医院心理科 北京 100044
Author(s):
MO Heng1 GAO Chengzhi1WANG Shaojie2QU Shan3
1Department of Stomatology, the People′s Hospital of Peking University, Beijing 1000442Department of Chinese Medicine, the People′s Hospital of Peking University, Beijing 1000443Department of Psychology, the People′s Hospital of Peking University, Beijing 100044
关键词:
口腔扁平苔藓焦虑抑郁唾液皮质醇唾液脱氢表雄酮
Keywords:
oral lichen planus anxiety depression salivary cortisol salivary DHEA
分类号:
R781.5
摘要:
目的:探讨口腔扁平苔藓(OLP)患者情绪障碍与唾液皮质醇和脱氢表雄酮(DHEA)水平的相关性。方法:采用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评定非糜烂型OLP组(40例)、糜烂型OLP组(31例)和对照组(31例)的焦虑、抑郁状况,并在早晨采集唾液,通过放射免疫法对受试者的唾液皮质醇和DHEA水平进行测定,分析量表得分与唾液皮质醇和DHEA水平的相关性。结果:3组受试者的HAMA得分、HAMD得分、唾液皮质醇水平差异均有统计学意义(F=15.892、4.876和14.375,P<0.05),糜烂型OLP组HAMA得分、HAMD得分、唾液皮质醇水平均高于对照组和非糜烂型OLP组(P<0.05)。糜烂型OLP组唾液皮质醇水平与HAMA得分和HAMD得分(r=0.965、0.923,P<0.001)呈正相关,而唾液DHEA水平与HAMA得分和HAMD得分(r=-0.948、-0.966,P<0.001)呈负相关。非糜烂型OLP组唾液皮质醇水平与HAMA得分和HAMD得分(r=0.963、0.957,P<0.001)呈正相关,而唾液DHEA水平与HAMA得分和HAMD得分(r=-0.962、-0.971,P<0.001)呈负相关。结论:糜烂型OLP的发生、发展与焦虑、抑郁等情绪障碍有关,其作用机制可能是通过应激反应导致糜烂型OLP患者的唾液皮质醇水平升高,但是否与唾液DHEA水平的降低相关还有待进一步的研究。
Abstract:
Aim: To explore the relationship between scores of anxiety, depression and the salivary levels of cortisol, DHEA in patients with oral lichen planus(OLP).Methods: Thirtyone patients with erosive oral lichen planus(EOLP),40 patients with nonEOLP and 31 control patients were investigated by the instruments Hamilton Anxiety Scale and Hamilton Depression Scale, respectively. Saliva was collected in the morning for the determination of cortisol, DHEA levels by radioimmunoassay to explore the relationship between scores of anxiety, depression and the salivary levels of cortisol, DHEA in the three groups.Results: There were significant differences in the scores of HAMA, HAMD and the concentration of salivary cortisol of objects in three groups(F=15.892,4.876 and 14.375,P<0.05).Compared with controls and patients with nonEOLP, the scores of HAMA, HAMD and the concentration of salivary cortisol in patients with EOLP were significantly higher(P<0.05). In addition, the concentration of salivary cortisol in patients with EOLP was positively correlated with their scores of HAMA(r=0.965,P<0.001) and HAMD (r=0.923,P<0.001).The concentration of salivary DHEA in patients with EOLP was negatively correlated with their scores of HAMA (r=-0.948,P<0.001) and HAMD (r=-0.966,P<0.001).The concentration of salivary cortisol in patients with nonEOLP was positively correlated with their cores of HAMA (r=0.963,P<0.001) and HAMD (r=0.957,P<0.001). The concentration of salivary DHEA in patients with nonEOLP was negatively correlated with their scores of HAMA(r=-0.962,P<0.001)and HAMD(r=-0.971,P<0.001).Conclusion: The pathogenesis and exacerbation of EOLP could be inferred by the mood obstacle. Anxiety and depression may result in higher concentration of salivary cortisol in patients with EOLP by means of psychosomatic response to stress. While the relation between anxiety, depression and lower salivary DHEA levels in patients with EOLP remains unclear and more research is needed in future.

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更新日期/Last Update: 1900-01-01