[1]邵世清,杨少琴#,黄贵,等.良恶性卵巢甲状腺肿组织中CK19、Galectin3、CD56蛋白的表达及鉴别诊断价值[J].郑州大学学报(医学版),2015,(06):847-849.
 SHAO Shiqing,YANG Shaoqin,HUANG Gui,et al.Value of CK19,Galectin3,and CD56 in the differential diagnosis about benign and malignant struma ovarii[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(06):847-849.
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良恶性卵巢甲状腺肿组织中CK19、Galectin3、CD56蛋白的表达及鉴别诊断价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2015年06期
页码:
847-849
栏目:
应用研究
出版日期:
2015-12-20

文章信息/Info

Title:
Value of CK19,Galectin3,and CD56 in the differential diagnosis about benign and malignant struma ovarii
作者:
邵世清1杨少琴1#黄贵2田君1张红霞1王社莲1
1河南大学淮河医院妇产科 开封4750002河南大学淮河医院病理科 开封 475000
Author(s):
SHAO Shiqing1YANG Shaoqin1HUANG Gui2TIAN Jun1ZHANG Hongxia1WANG Shelian1
1Department of Obstetrics and Gynecology,Huaihe Hospital,Henan University,Kaifeng 4750002Department of Pathology,Huaihe Hospital,Henan University,Kaifeng 475000
关键词:
卵巢甲状腺肿CK19Galectin3CD56
Keywords:
struma ovariiCK19Galectin3CD56
分类号:
R711
摘要:
目的:探讨CK19、Galectin3及CD56在良恶性卵巢甲状腺肿鉴别诊断中的应用价值。方法:采用免疫组化法检测6例卵巢甲状腺癌和10例卵巢甲状腺肿组织中CK19、Galectin3及CD56蛋白表达情况。结果:卵巢甲状腺癌组织中CK19、Galectin3蛋白的表达高于卵巢甲状腺肿组织(t=4.807,3.835,P均<0.05),CD56蛋白的表达低于卵巢甲状腺肿组织(t=3.105,P均<0.05)。分别利用CK19、Galectin3及CD56蛋白表达水平绘制ROC曲线,曲线下面积(AUC)分别为0.983、0.933和0.867;以其中1个指标恶性即判定为恶性,则3者联合检测对良恶性卵巢甲状腺肿鉴别诊断的灵敏度可达100%。结论:CK19、Galectin3及CD56对卵巢甲状腺肿良恶性的鉴别有很好的应用价值。
Abstract:
Aim: To explore the value of CK19,Galectin3 and CD56 in differential diagnosis about benign and malignant struma ovarii.Methods: The expressions of CK19,Galectin3,and CD56 protein in 6 cases of thyroid carcinoma of ovary and 10 cases of ovarian goiter tissue were detected using immunohistochemical staining technique.Results: Compared with those of the ovarian goiter tissue, the expressions of CK19 and Galectin3 were higher and CD56 protein expression was lower in thyroid carcinoma of ovary tissue(t=4.807,3.835,3.105,P<0.05).The AUC of ROC about CK19,Galectin3,and CD56 protein was 0.983,0.933 and 0.867,respectively, and sensitivity of the joint detection with the 3 proteins was 100%.Conclusion: CK19,Galectin3 and CD56 may be used as diagnostic indicators of benign and malignant struma ovarii.

参考文献/References:


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更新日期/Last Update: 1900-01-01