[1]申明惠,王晓飞,刘敏,等.河南汉族CYP2C19基因多态性对氯吡格雷药物代谢动力学的影响[J].郑州大学学报(医学版),2016,(01):95-98.
 SHEN Minghui,WANG Xiaofei,LIU Min,et al.Effect of CYP2C19 genetic polymorphism on pharmacokinetics of clopidogrel[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(01):95-98.
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河南汉族CYP2C19基因多态性对氯吡格雷药物代谢动力学的影响()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年01期
页码:
95-98
栏目:
应用研究
出版日期:
2016-01-20

文章信息/Info

Title:
Effect of CYP2C19 genetic polymorphism on pharmacokinetics of clopidogrel
作者:
申明惠1王晓飞2刘敏1杨卫红3黄晨征3张胜军4张莉蓉3#
1)郑州大学附属中心医院科教科 郑州 4500072)郑州大学附属郑州中心医院转化医学中心 郑州 4500073)郑州大学基础医学院药理学教研室 郑州 4500014)郑州大学第一附属医院临床药理研究中心 郑州 450052
Author(s):
SHEN Minghui1WANG Xiaofei2LIU Min1YANG Weihong3HUANG Chenzheng3ZHANG Shengjun4ZHANG Lirong3
1)Department of Science and Education,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 4500072)Translational Medicine Center,Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 4500073)Department of Pharmacology,School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 4500014)Clinical Pharmacology Research Center,the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
CYP2C19基因多态性氯吡格雷药物代谢动力学河南省汉族
Keywords:
CYP2C19gene polymorphismsclopidogrelpharmacokineticsHenanHan population
分类号:
R558
文献标志码:
A
摘要:
目的:探讨CYP2C19基因多态性对氯吡格雷人体药物代谢动力学的影响。方法:43名健康受试者在单次服用75 mg氯吡格雷片后,定时采血,用液质联用技术(LCMS/MS)分析受试者氯吡格雷血药浓度,采用PCR限制性片段长度多态性分析法检测CYP2C19*2、*3基因突变。结果:CYP2C19*1/*1、CYP2C19*1/*2和CYP2C19*2/*2(*3)3种基因型分别为13、24和6例。药时曲线下面积(AUC)024和AUC0∞在三种基因型间比较,差异有统计学意义(P<0.05)。结论:口服氯吡格雷后,CYP2C19不同基因型AUC不同。
Abstract:
Aim: To determine the effect of CYP2C19 genetic polymorphism on the pharmacokinetics of clopidogrel in healthy Chinese subjects.Methods: A total of 43 unrelated healthy Han subjects were enrolled, and each of them received a single dose of 75 mg clopidogrel tablet. Multiple blood samples were collected and the plasma concentrations of clopidogrel were determined by a validated liquid chromatography/tandem mass spectrometry. PCRrestriction fragment length polymorphism analysis was performed to detect the CYP2C19*2 and *3 gene mutations.Results: The number of the inviduals carrying CYP2C19*1/*1, CYP2C19*1/*2 and CYP2C19*2/*2 (*3) were 13, 24 and 6, respectively. There were significant differences in the various genotype groups of AUC024 and AUC0∞(P<0.05).Conclusion: CYP2C19 polymorphisms affect the AUC of clopidogrel.

参考文献/References:

[1]陈昕朦,金晶,黄民,等.CYP2C19、P2Y12基因多态性与缺血性脑卒中患者氯吡格雷抵抗的相关性研究[J].中国药师,2014,17(6):885
[2]丁肖梁,谬丽燕.氯吡格雷个体差异的遗传药理学研究进展[J].中国临床药理学杂志,2010(9):701
[3]赖胜荣,刘俊.药物基因组学与抗血小板药物抵抗研究进展[J].药学与临床研究,2014,22(2):155
[4]刘俊,朱艳虹,栾家杰,等.基因型检测在氯吡格雷个体化抗血小板治疗中的应用价值[J].中国药房,2014,25(12):1097
[5]LEE JB,LEE KA,LEE KY.Cytochrome P450 2C19 polymorphism is associated with reduced clopidogrel response in cerebrovascular disease[J].Yonsei Med J,2011,52(5):734
[6]KUBICA A,KOZINSKI M,GRZESK G,et al.Genetic determinants of platelet response to clopidogrel[J].J Thromb Thrombolysis,2011,32(4):459
[7]SIBBING D,KOCH W,GEBHARD D,et al.Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogreltreated patients with coronary stent placement[J].Circulation,2010,121(4):512
[8]罗薇,王鹤尧,刘丽宏,等.CYP2C19多态性对奥美拉唑药代动力学的影响[J].临床药物治疗杂志,2013,11(2):22
[9]SOFI F,GIUSTI B,MARCUCCI R,et al.Cytochrome P450 2C19*2 polymorphism and cardiovascular recurrences in patients taking clopidogrel:a metaanalysis[J].Pharmacogenomics J,2011,11(3):199
[10]GIUSTI B, GORI AM, MARCUCCI R, et al. Drug and medical device interactions:stent thrombosis and personalizing clopidogrel therapy [J]. Curr Pharmacogenomics Pers Med, 2010, 8(2): 124
[11]SIMON T,VERSTUYFT C,MARYKRAUSE M,et al.Genetic determinants of response to clopidogrel and cardiovascular events[J].N Engl J Med,2009,360(4):363
[12]张林.CYP2C19基因多态性分析及其与奥美拉唑疗效关系的临床研究[D].长春:吉林大学,2004.
[13]马晶晶,李金恒,曹晓梅,等.CYP2C19基因多态性对奥美拉唑药动学与相对生物利用度的影响[J].中国药理学通报,2010,26(2):258
[14]胡祥鹏,许建明,胡咏梅,等.CYP2C19基因多态性对奥美拉唑在中国人体内的药物动力学和药效学的影响[J].中国药理学通报,2005,21(10):67

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更新日期/Last Update: 1900-01-01