[1]季玉陈,李妍,胡京霞,等.胶质瘤组织中microRNA-200a的表达及其与患者预后的关系[J].郑州大学学报(医学版),2016,(01):105-107.
 JI Yuchen,LI Yan,HU Jingxia,et al.MicroRNA200a expression in glioma tissue and its value in predicting prognosis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(01):105-107.
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胶质瘤组织中microRNA-200a的表达及其与患者预后的关系()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年01期
页码:
105-107
栏目:
应用研究
出版日期:
2016-01-20

文章信息/Info

Title:
MicroRNA200a expression in glioma tissue and its value in predicting prognosis
作者:
季玉陈1李妍1胡京霞1张红波2左焕琮1#
1)清华大学玉泉医院神经外科 北京 1000492)湖北省新华医院神经外科 武汉 430015
Author(s):
JI Yuchen1LI Yan1HU Jingxia1ZHANG Hongbo2ZUO Huancong1
1)Department of Neurosurgery,Yuquan Hospital,Tsinghua University,Beijing 1000492)Department of Neurosurgery,Xinhua Hospital of Hubei Province,Wuhan 430015
关键词:
microRNA200a胶质瘤预后
Keywords:
microRNA200agliomaprognosis
分类号:
R730.264
文献标志码:
A
摘要:
目的:探讨胶质瘤组织中microRNA200a的表达及其在预测胶质瘤患者预后中的价值。方法:采用RTPCR方法检测63例胶质瘤及14例正常脑组织中microRNA200a的表达水平。结果:胶质瘤组织中microRNA200a的表达水平高于正常脑组织中的表达水平(P<0.001)。胶质瘤组织中microRNA200a的表达水平与胶质瘤组织学分级有关(P<0.001),而与患者年龄、性别、KPS评分、肿瘤直径等均无关(P均>0.05)。microRNA200a高表达的胶质瘤患者死亡风险较低表达的胶质瘤患者高(P<0.001)。结论:microRNA200a在胶质瘤组织中表达增高,可作为评价胶质瘤预后的独立因素。
Abstract:
Aim: To investigate the relationship between microRNA200a expression and clinicopathologic factors in glioma tissue and assess its value in predicting the prognosis of glioma patients.Methods: The microRNA200a expression of 63 cases of glioma and 14 cases of normal brain tissue were detected by RTPCR.Results: The microRNA200a expression in glioma tissue was significantly higher than that in normal brain tissue(P<0.001). The high expression of microRNA200a was related with histological grade(P<0.001), but not with age,gender,tumor size,or KPS scale(P>0.05).The microRNA200a appeared as an independent prognostic factor(P<0.001).Conclusion: Increased microRNA200a expression in glioma tissue could be an independent factor predicting poor prognosis.

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更新日期/Last Update: 1900-01-01