[1]段雷振),杨跃进),周 桐),等.氟病区成人雌激素受体α基因PvuⅡ多态性与骨组织异常的关系*[J].郑州大学学报(医学版),2016,(02):180-183.
 DUAN Leizhen),YANG Yuejin),ZHOU Tong),et al.ERα gene PvuⅡpolymorphism and bone tissue abnormalities in adults exposed to fluoride[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(02):180-183.
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氟病区成人雌激素受体α基因PvuⅡ多态性与骨组织异常的关系*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年02期
页码:
180-183
栏目:
论著
出版日期:
2016-03-20

文章信息/Info

Title:
ERα gene PvuⅡpolymorphism and bone tissue abnormalities in adults exposed to fluoride
作者:
段雷振1)杨跃进2)周 桐1)崔留欣1)丁 中2)李世宏2)程学敏1)赵明旭1)周郭育1)巴 月1)#
1)郑州大学公共卫生学院环境卫生学教研室 郑州 450001
2)开封市疾病预防控制中心地方病科 开封 475000
Author(s):
DUAN Leizhen1)YANG Yuejin2)ZHOU Tong1)CUI Liuxin1)DING Zhong2)LI Shihong2)CHENG Xuemin1)ZHAO Mingxu1)ZHOU Guoyu1)BA Yue1)
1)Department of Environmental Health,College of Public Health,Zhengzhou University,Zhengzhou 450001
2)Department of Endemic Disease,Kaifeng Center for Disease Prevention and Control,Kaifeng 475000
关键词:
雌激素受体 基因多态性 骨组织
Keywords:
fluoride estrogen receptor gene polymorphism bone tissue
分类号:
R599
摘要:
目的:探讨雌激素受体(ER)α基因PvuⅡ多态性与氟暴露地区成人骨组织异常的关系。方法:采用整群抽样方法,在氟病区及对照区选择当地出生或居住5 a以上18~55岁的人群为观察对象; 采用PCR-RFLP法分析ERα基因PvuⅡ多态性; 采用X线检查两区人群骨组织改变。结果:暴露组和对照组人群骨组织异常率分别为65.34%和40.32%,差异有统计学意义(P<0.05); 以pp基因型为参照,暴露组携带Pp/PP人群骨组织异常的危险性增高(PR=1.087, 95%CI=1.0531.437或PR=1.145, 95%CI=1.104~1.318)。结论:携带ERα PvuⅡPp/PP基因型可能增加骨组织对氟暴露敏感性。
Abstract:
Aim: To explore the relationship between estrogen receptor α(ERα)gene polymorphism and bone tissue abnormalities in adults exposed to fluoride in drinking water.Methods: Adults aged from 18 to 55 years old who were born and grew or lived there for at least 5 years in endemic fluorosis villages or control villages were recruited using cluster sampling. They were allocated into endemic fluorosis group and control group in accordance with the above areas. PCR-RFLP was used to determine PvuⅡ genotype in ERα gene. X-ray was used to detect changes of the subjects' bone tissue of the two groups.Results: The abnormal rate of bone tissue in endemic fluorosis group(65.34%)were significantly higher than that in control group(40.32%)(P<0.05). The increased risk of bone tissue abnormalities was observed in subjects carrying Pp/PP genotype of ERα gene compared with subjects carrying pp genotype from endemic fluorosis group(PR=1.087,95%CI=1.053-1.437; PR=1.145,95%CI=1.104-1.318).Conclusion: Bone tissue in people who carried ERα PvuⅡ Pp/PP genotype may be more susceptible to fluoride exposure.

参考文献/References:

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目 81072247; 河南省教育厅科学技术研究重点项目 13A330653
#通信作者,女,1963年7月生,博士,教授,研究方向:环境相关疾病分子发病机制,E-mail:byyue@zzu.edu.cn
更新日期/Last Update: 2016-03-20