[1]宋文妍△,王雪改,孙莹璞,等.三种促排卵方案对不同年龄子宫内膜异位症患者IVF-ET妊娠及出生结局的影响*[J].郑州大学学报(医学版),2016,(02):227-233.
 SONG Wenyan,WANG Xuegai,SUN Yingpu,et al.Effect of three down-regulation protocols on outcome of IVF-ET in endometriosis patients with different ages[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(02):227-233.
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三种促排卵方案对不同年龄子宫内膜异位症患者IVF-ET妊娠及出生结局的影响*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年02期
页码:
227-233
栏目:
应用研究
出版日期:
2016-03-20

文章信息/Info

Title:
Effect of three down-regulation protocols on outcome of IVF-ET in endometriosis patients with different ages
作者:
宋文妍王雪改孙莹璞金海霞姚桂东彭兆锋石森林杨洪毅张向阳
郑州大学第一附属医院生殖医学中心 郑州 450052
Author(s):
SONG WenyanWANG Xuegai SUN YingpuJIN Haixia YAO Guidong PENG Zhaofeng SHI Senlin YANG Hongyi ZHANG Xiangyang
Reproductive Medical Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
子宫内膜异位症 体外受精-胚胎移植 控制性超促排卵 长方案 超长方案 改良超长方案
Keywords:
endometriosis in vitro fertilization-embryo transfer controlled ovarian stimulation long protocol prolonged protocol modified super-long protocol
分类号:
R711.6
摘要:
目的:通过对比三种促排卵方案用于子宫内膜异位症(EMs)患者体外受精-胚胎移植(IVF-ET)的妊娠及出生结局,探讨不同年龄患者最佳促排卵方案。方法:回顾性分析行IVF-ET助孕治疗的165例EMs患者的203个周期的临床资料。按年龄及促排卵方案进行分组:年龄<35岁,分长方案组(n=51)、超长方案组(n=61)和改良超长方案组(n=24); 年龄≥35岁,分长方案组(n=16)、超长方案组(n=33)和改良超长方案组(n=18)。统计各组实验室结果、妊娠结局及出生婴儿各项指标。结果:①年龄<35岁者超长方案组的正常卵裂率(99.3% vs 96.0%,P=0.008)、优质胚胎率(75.7% vs 67.1%,P=0.021)、着床率(42.2% vs 27.1%,P=0.022)和临床妊娠率(63.3% vs 37.8%,P=0.011)均高于长方案组; ②年龄≥35岁者改良超长方案组的可移植胚胎率(93.5% vs 70.4% vs 75.5%,P=0.011)、优质胚胎率(91.9% vs 55.1% vs 65.5%,P<0.001)和胚胎利用率(95.1% vs 72.6% vs 79.4%,P=0.002)均高于长方案组和超长方案组。结论:年龄<35岁EMs患者采用长方案促排卵效果不佳,而采用超长方案促排卵临床结局相对较好; 年龄≥35岁EMs患者采用改良超长方案促排卵实验室结果最佳。
Abstract:
Aim: To investigate the best protocol for different aged patients with endometriosis(EMs)by comparing the effect of three down-regulation protocols on the outcome of IVF-ET.Methods: A total of 203 cycles with 165 EMs patients undergoing IVF-ET were retrospectively evaluated. The patients were grouped according to their ages and three down-regulation protocols:for patients under 35 years old, there were 51 cycles received long protocol,61 cycles received prolonged protocol and 24 cycles received modified super-long protocol; for patients over 35(including 35)years old, they were also grouped into three protocols(16 cycles,33 cycles and 18 cycles, respectively).The laboratory outcome,clinical outcome and the indicators of live-born babies were statistically analyzed between the groups.Results: For patients under 35 years old:higher cleavage rate(99.3% vs 96.0%,P=0.008)and higher good-quality embryo rate(75.7% vs 67.1%,P=0.021), higher implantation rate(42.2% vs 27.1%,P=0.022), higher clinical pregnancy rate(63.3% vs 37.8%,P=0.011), were observed in prolonged protocol group compared with those of long protocol group.For patients over 35 years old:the transferable embryo rate(93.5% vs 70.4% vs 75.5%,P=0.011), good-quality embryo rate(91.9% vs 55.1% vs 65.5%,P<0.001)and embryo utilization rate(95.1% vs 72.6% vs 79.4%,P=0.002)of modified super-long protocol group were significantly higher than those of long protocol group and prolonged protocol group.Conclusion: For patients with EMs under 35 years old,the long protocol is not very suitable, while the prolonged protocol has a relatively better clinical outcome; and for patients with EMs over 35 years old, the laboratory outcome can be the best if using the modified super-long protocol.

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备注/Memo

备注/Memo:
*郑州市科技局项目 340600531813; 郑州大学第一附属医院青年基金
△女,1973年1月生,博士,副主任医师,副教授,研究方向:生殖医学,E-mail:csxok@163.com
更新日期/Last Update: 2016-03-20