[1]叶 莹,史鲁斌,李 军,等.河南省2009至2014年疑似预防接种异常反应监测分析[J].郑州大学学报(医学版),2016,(02):258-262.
 YE Ying,SHI Lubin,LI Jun,et al.Analysis on surveillance of suspected adverse events following immunization in Henan Province, 2009-2014[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(02):258-262.
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河南省2009至2014年疑似预防接种异常反应监测分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年02期
页码:
258-262
栏目:
应用研究
出版日期:
2016-03-20

文章信息/Info

Title:
Analysis on surveillance of suspected adverse events following immunization in Henan Province, 2009-2014
作者:
叶 莹史鲁斌李 军姬艳芳于 燕董蒲梅张延炀#
河南省疾病预防控制中心免疫预防与规划所 郑州 450016
Author(s):
YE YingSHI Lubin LI Jun JI Yanfang YU Yan DONG Pumei ZHANG Yanyang
Immune Planning Division,Henan Center for Disease Control and Prevention, Zhengzhou 450016
关键词:
疑似预防接种异常反应 疫苗 监测 河南省
Keywords:
suspected adverse events following immunization vaccine surveillance Henan Province
分类号:
R186.3
摘要:
目的:分析河南省2009至2014年疑似预防接种异常反应(AEFI)的发生特征,评价疫苗安全性。方法:通过中国疾病预防控制信息系统AEFI信息管理系统,收集河南省2009至2014年报告的AEFI个案数据,采用描述流行病学方法进行分析。结果:河南省2009至2014年共收集AEFI个案13 282例,年均报告发生率为54.41/100万剂,其中严重AEFI 356例,报告发生率为1.46/100万剂。男女性别比为1.36GA6FA1; 2岁以下儿童占71.33%; 报告病例主要集中在洛阳、郑州和焦作等地。报告数最多的疫苗是吸附无细胞百白破疫苗(4 070例),报告发生率最高的是7价肺炎疫苗(790.00/100万剂),严重AEFI报告发生率最高的为麻疹疫苗(56.19/100万剂)。AEFI一般反应临床损害以发热、红肿、硬结为主,异常反应以过敏反应性疾病为主。所有AEFI中,治愈或好转占98.93%。60例死亡病例中,异常反应死亡18例。结论:较低的严重AEFI报告发生率和较好的预后提示河南省疫苗安全性良好。
Abstract:
Aim: To analyze the occurrence features of suspected adverse events following immunization(AEFI)in Henan Province,2009-2014, and to provide the basis for evaluation of vaccine safety.Methods: 2009-2014 AEFI data were collected through the Chinese Disease Prevention and Control Information System for AEFI information management system. The descriptive methodology was used in the study.Results: A total of 13 282 AEFI cases were reported in Henan Province 2009-2014,and the reported incidence rate was 54.41 per 1 000 000 doses, in which, 356 cases were serious AEFI and the reported incidence rate was 1.46 per 1 000 000 doses. The ratio of male to female was 1.36GA6FA1, cases<2 year old accounted for 71.33%, and the reported cases were mainly concentrated in Luoyang, Zhengzhou, and Jiaozuo. The largest number of cases of vaccine was Adsorbed Diphtheria, Tetanus and Acellular Pertusis Combined Vaccine(4 070 cases), the highest reported incidence rate of vaccine was 7 pneumococcal conjugate vaccine(790.00 per 1 000 000), and the highest reported incidence rate of serious AEFI was measles vaccine(56.19 per 1 000 000). The main symptoms of common vaccine reactions were fever, local swelling and indurations, the main diagnosis of rare vaccine reactions was anaphylactic disorders. Out of all AEFI cases, 98.93% were recovered or got better. In 60 death cases, 18 were rare vaccine reactions.Conclusion: Lower incidence rate of serious AEFI and better prognosis showed that vaccine safety is good in Henan Province.

参考文献/References:

[1] 武文娣,刘大卫,李克莉,等.中国2012年疑似预防接种异常反应监测数据分析[J].中国疫苗和免疫,2014,20(1):1
[2] 张英洁,张伟燕,宋立志,等.山东省2011年疑似预防接种异常反应监测分析[J].中国疫苗和免疫,2013,19(1):57
[3] MAHAJAN D,DEY A,COOK J,et al.Surveillance of adverse events following immunization in Australia,2012[J].Commun Dis Intell Q Rep,2014,38(3):e232
[4] WISE RP,ISKANDER J,PRATT RD,et al.Postlicensure safety surveillance for 7-valent pneumococcal conjugate vaccine[J].JAMA,2004,292(14):1702
[5] 曾雪霞,陈少明,莫少雄,等.海南省2010年麻疹疫苗强化免疫活动AEFI监测与处置[J].中国热带医学,2012,12(5):552
[6] 凌罗亚,胡昱,陈恩富,等.浙江省2010年麻疹-流行性腮腺炎联合减毒活疫苗强化免疫疑似预防接种异常反应监测分析[J].中国疫苗和免疫,2011,17(4):357
[7] THOON KC,SOH SB,LIEW WK,et al.Active surveillance of adverse events following childhood immunization in Singapore[J].Vaccine,2014,32(39):5000
[8] 汪志国,张晋琳,马福宝.2009-2012年江苏省预防接种后死亡病例病因分析[J].中华预防医学杂志,2014,48(6):532

备注/Memo

备注/Memo:
#通信作者,男,1976年3月生,本科,副主任医师,研究方向:疫苗可预防疾病的流行病学,E-mail: henan_epi2@163.com
更新日期/Last Update: 2016-03-20