[1]方 谦△,穆 玉,周 雪,等.生物活性玻璃对体外脱矿釉质再矿化的影响[J].郑州大学学报(医学版),2016,(02):263-266.
 FANG Qian,MU Yu,ZHOU Xue,et al.Effect of bioactive glass on demineralization enamel remineralization in vitro[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(02):263-266.
点击复制

生物活性玻璃对体外脱矿釉质再矿化的影响()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年02期
页码:
263-266
栏目:
应用研究
出版日期:
2016-03-20

文章信息/Info

Title:
Effect of bioactive glass on demineralization enamel remineralization in vitro
作者:
方 谦穆 玉周 雪瞿亚男彭 伟
华北理工大学口腔医学院 唐山 063000
Author(s):
FANG QianMU YuZHOU Xue QU YananPENG Wei
College of Stomatology,North China University of Science and Technology,Tangshan 063000
关键词:
生物活性玻璃 再矿化 显微硬度 脱矿釉质
Keywords:
bioactive glass remineralization microhardness demineralization enamel
分类号:
R781.1
摘要:
目的:观察生物活性玻璃对早期脱矿釉质再矿化的作用。方法:将40块牛牙釉质块建立人工龋模型后随机分为4组:生物活性玻璃组(用质量分数6%生物活性玻璃进行再矿化处理)、GC护牙素组、NaF组(用质量分数2%NaF进行再矿化处理)和去离子水组。采用pH循环法进行再矿化处理,2次/d,5 min/次,循环15 d。用显微硬度仪测量脱矿前、再矿化前及再矿化后牙釉质表面的显微硬度,荧光显微镜观察早期釉质龋表层下的荧光带厚度,测定脱矿深度。结果:生物活性玻璃组、GC护牙素组、NaF组再矿化后显微硬度均较再矿化前增加,且生物活性玻璃组提高幅度最大(P<0.05)。4组再矿化区荧光带厚度均较脱矿区降低(P<0.05),其中生物活性玻璃组、GC护牙素组、NaF组均大于去离子水组(P<0.05)。结论:质量分数6%生物活性玻璃溶液促进脱矿釉质再矿化的疗效较好。
Abstract:
Aim: To observe the effect of bioactive glass on the remineralization of demineralization enamel.Methods: Forty bovine teeth were subjected to establish demineralization enamel model, and then were allocated into four groups randomly(10 in each group)and treated with 6% bioactive glass, casein phosphopeptide amorphous calcium phosphate(CPP-ACP),2% sodium fluoride(NaF)and deionized water,respectively.Then they were subjected to the pH-cycling,two times a day and 5 minutes each time, cycling for 15 days for remineralization. The surface microhardness(SMH)of the enamel before demineralization,before and after remineralization were measured by microhardness detector. Thickness of fluorescence beneath the surface of early enamel caries in the demineralization area and the remineralization area were detected by fluorescence microscopy.Results: The SMH after remineralization in bioactive glass,CPP-ACP and NaF groups was higher than those before remineralization, and the change of bioactive glass group was the highest(P<0.05). The thickness of fluorescence in the remineralization area was lower than that in the demineralization area in the four groups(P<0.05), and the demineralization depth of bioactive glass,CPP-ACP and NaF groups was higher than the deionized water group(P<0.05).Conclusion: 6% bioactive glass solution had better effect on remineralization of demineralization enamel.

参考文献/References:

[1] AOBA T.Solubility properties of human tooth mineral and pathogenesis of dental caries[J].Oral Dis,2004,10(5):249
[2] 方谦,周雪,穆玉,等.生物活性玻璃促进早期釉质龋再矿化最适浓度的研究[J].天津医药,2015,43(10):1187
[3] 方谦,穆玉,徐晓南,等.不同浓度生物活性玻璃对早期釉质龋齿再矿化的作用[J].牙体牙髓牙周病杂志,2015,25(12):729
[4] 孙皎,赵信义.口腔生物材料学[M].北京:人民卫生出版社,2011:127
[5] 罗菁菁,唐旭炎,李全利.酪蛋白磷酸肽-无定形磷酸钙促进牙再矿化的机制[J].国际口腔医学杂志,2011,38(6):662
[6] POGGIO C,LOMBARDINI M,DAGNA A,et al.Protective effect on enamel demineralization of a CPP-ACP paste: an AFM in vitro study[J].J Dent,2009,37(12):949
[7] HAMBA H,NIKAIDO T,INOUE G,et al.Effects of CPP-ACP with sodium fluoride on inhibition of bovine enamel demineralization: a quantitative assessment using micro-computed tomography[J].J Dent,2011,39(6):405
[8] 史舒雅,陈亚明.生物活性玻璃在口腔医学中的应用[J].口腔生物医学,2013,4(1):44
[9] BAKRY AS,MARGHALANI HY,AMIN OA,et al.The effect of a bioglass paste on enamel exposed to erosive challenge[J].J Dent,2014,42(11):1458
[10]MEHTA AB,KUMARI V,JOSE R,et al.Remineralization potential of bioactive glass and casein phosphopeptide-amorphous calcium phosphate on initial carious lesion:an in-vitro pH-cycling study[J].J Conserv Dent,2014,17(1):3
[11]黄冠玮,邹玲,李伟.人工龋模型的建立方法[J].国际口腔医学杂志,2010,37(5):537
[12]ANDERSSON OH,KANGASNIEMI I.Calcium phosphate formation at the surface of bioactive glass in vitro[J].J Biomed Mater Res,1991,25(8):1019
[13]刘振华,王铎,贺长历.硅对人恒前磨牙早期釉质龋再矿化影响的扫描电镜观察[J].中华老年口腔医学杂志,2011,9(2):74
[14]樊明文,周学东.牙体牙髓牙周病学[M].北京:人民卫生出版社,2012:52

备注/Memo

备注/Memo:
△女,1988年11月生,硕士,医师,研究方向:口腔内科学,E-mail:416385376@qq.com
更新日期/Last Update: 2016-03-20