[1]史娜娜,吴博文,孙 慧,等.t(8; 21)急性髓系白血病的临床特征及预后分析[J].郑州大学学报(医学版),2016,(03):409-412.
 SHI Nana,WU Bowen,SUN Hui,et al.Clinical features and prognostic factors of acute myeloid leukemia with t(8; 21)[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(03):409-412.
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t(8; 21)急性髓系白血病的临床特征及预后分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年03期
页码:
409-412
栏目:
应用研究
出版日期:
2016-05-20

文章信息/Info

Title:
Clinical features and prognostic factors of acute myeloid leukemia with t(8; 21)
作者:
史娜娜吴博文孙 慧刘延方马 杰谢新生刘林湘姜中兴孙 玲#
郑州大学第一附属医院血液内科 郑州 450052
Author(s):
SHI NanaWU BowenSUN HuiLIU YanfangMA JieXIE XinshengLIU LinxiangJIANG ZhongxingSUN Ling
Department of Hematology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
白血病非淋巴细胞急性 白细胞指数 染色体 治疗 预后
Keywords:
leukemianonlymphocyticacute white blood cell index chromosome therapy prognosis
分类号:
R551.3
摘要:
目的:观察 t(8; 21)急性髓系白血病(AML)的临床特征并分析影响预后的因素。方法:回顾性分析郑州大学第一附属医院68例初治成人t(8; 21)AML患者的血常规、骨髓细胞形态学、免疫表型、细胞遗传学、疗效及生存状况,分析影响总体生存(OS)、无复发生存(RFS)的因素。结果:68例 t(8; 21)AML按FAB分型1例为M1型,1例为M4型,66例为M2型。单纯t(8; 21)AML 病例占38.2%(26/68),伴附加染色体异常病例占61.8%(42/68),主要为伴性染色体(-Y或-X)缺失。59例行流式细胞术检测,CD34 阳性率93.2%, CD19 阳性率54.2%,CD56阳性率79.7%,CD34CD19共表达者占54.2%。总体完全缓解(CR)率为94.1%(64/68),1个疗程CR率为73.5%(50/68)。64例可统计生存的患者3 a OS率为44.8%,3 a RFS率为47.9%。白细胞指数、染色体核型、中大剂量Ara-C疗程数对OS有影响(P<0.05)。结论:白细胞指数、染色体核型、中大剂量Ara-C疗程数是影响t(8; 21)AML预后的主要因素。
Abstract:
Aim: To investigate the clinical features and the prognostic factors of acute myeloid leukemia(AML)with t(8; 21).Methods: A total of 68 AML patients with t(8; 21)in the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed,including white blood cell index,marrow morphology,immunophenotype,chromosome karyotype,therapeutic effects,as well as the overall survival(OS)and relapse free survival(RFS).The prognostic factors were analyzed.Results: According to FAB classification,there were 66 cases of M2,1 case of M1, and 1 case of M4. Cytogenetically,38.2%(26/68)were simply t(8; 21), while 61.8%(42/68)were accompanied with additional chromosomal abnormalities,mainly loss of sex chromosome(-Y or -X).Out of all the 59 cases with flow cytometry results,the positive rate of CD34 according to immunophenotype analysis was 93.2%,that of CD19 was 54.2%,that of CD56 was 79.7%, and that of CD34CD19 was 54.2%. The overall complete remission(CR)rate was 94.1%(64/68),CR rate after the first course was 73.5%(50/68). The 3 year OS rate was 44.8% and 3 year FRS rate was 47.9%. White blood cell index,chromosome karyotype,intermediate/high dose cytarabine(IDAC)courses were influencing factors for OS(P<0.05).Conclusion: White blood cell index,chromosome karyotype, IDAC courses are important prognostic influencing factors for AML with t(8; 21).

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备注/Memo

备注/Memo:
#通信作者,女,1957年12月生,博士,主任医师,研究方向:造血系统恶性疾病的基础及临床,E-mail:sunling6686@126.com
更新日期/Last Update: 2016-05-20