[1]白如平,程静林#,董铁立.右美托咪定对全弓置换术患者血清炎症因子的影响[J].郑州大学学报(医学版),2016,(03):415-417.
 BAI Ruping,CHENG Jinglin,DONG Tieli.Effects of dexmedetomidine on inflammatory factors in patients undergoing aortic arch replacement with cardiopulmonary bypass[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(03):415-417.
点击复制

右美托咪定对全弓置换术患者血清炎症因子的影响()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年03期
页码:
415-417
栏目:
应用研究
出版日期:
2016-05-20

文章信息/Info

Title:
Effects of dexmedetomidine on inflammatory factors in patients undergoing aortic arch replacement with cardiopulmonary bypass
作者:
白如平 程静林# 董铁立
郑州大学第二附属医院麻醉科 郑州 450014
Author(s):
BAI RupingCHENG JinglinDONG Tieli
Department of Anesthesiology, the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014
关键词:
右美托咪定 全弓置换 肿瘤坏死因子-α 白细胞介素-6 白细胞介素-1
Keywords:
dexmedetomidine aortic arch replacement TNF-α IL-6 IL-1
分类号:
R614.2
摘要:
目的:探讨右美托咪定对全弓置换术患者血清炎症因子的影响。方法:因A型急性主动脉夹层行全弓置换手术患者32例,将其分为2组:对照组(A组,19例)和右美托咪定组(B组,13例)。B组于进入手术室后静脉滴注负荷量右美托咪定1 μg/kg,以0.6 μg/(kg·h)静脉泵注至手术结束,A组给予等容量生理盐水持续输注。两组患者分别在麻醉诱导前(T1)、手术结束时(T2)、术后4 h(T3)、术后8 h(T4)、术后24 h(T5)测定血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1(IL-1)水平。结果:B组在T3、T4、T5时间点血清TNF-α、IL-6、IL-1水平均较A组明显降低(P<0.05)。结论:在全弓置换术中,静注右美托咪定,能够减少术后TNF-α、IL-6、IL-1的释放,抑制炎症反应,改善预后。
Abstract:
Aim: To evaluate the effects of dexmedetomidine on inflammatory factors in patients undergoing the aortic arch replacement with cardiopulmonary bypass.Methods: A total of 32 patients with type A acute aortic dissection undergoing the aortic arth replacement with CPB were allocated into 2 groups depending on the different anesthetic: control group(group A,19 patients)and dexmedetomidine group(group B,13 patients).A loading dose of dexmedetomidine at 1 μg/kg was injected intravenously after induction, followed by continuous infusion at 0.6 μg/(kg·h)until the end of operation in group B. While the equal volume of normal saline was given in group A. Before induction(T1), at the end of operation(T2), and at 4,8 and 24 h the after operation(T3,T4,T5), the serum levels of TNF-α, IL-6, and IL-1 were measured.Results: The serum TNF-α,IL-6,and IL-1 levels at T3,T4,and T5 decreased in group B than those in group A(P<0.05).Conclusion: Dexmedetomidine can reduce the postoperation inflammatory factors such as TNF-α,IL-6,and IL-1 concentrations, thus reducing organ injury during aortic arch replacement.

参考文献/References:

[1] LI M,LUO N,BAI Z,et al.A canine model of multiple organ dysfunction following acute type-A aortic dissection[J].Surg Today,2012,42(9):876
[2] 张加强,张卫.右美托咪定对体外循环下心脏瓣膜置换术患者炎性反应的影响[J].中华麻醉学杂志,2013,33(10):1188
[3] 王伟,田福宏,严六狮.小剂量氯胺酮预处理对大鼠气腹所致小肠缺血再灌注损伤的保护作用[J].南方医科大学学报,2013,33(11):1685
[4] ZHANG L,ZHANG J,YANG L,et al.Isoflurane and sevo-flurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells[J].Br J Anaesth,2013,110(Suppl 1):i82
[5] 魏红芳,陈永学,李书河,等.右美托咪定对急性颅脑损伤患者围术期炎性反应的影响[J].中华麻醉学杂志,2012,32(10):1249
[6] SHI QQ,WANG H,FANG H.Dose-response and mechanism of protective functions of selective alpha-2 agonist dexmedetomidine on acute lung injury in rats[J].Saudi Med J,2012,33(4):375
[7] 李远强,王志刚,宫本晶,等.不同剂量右美托咪定对体外循环下心内直视手术患儿肺损伤的影响[J].中华麻醉学杂志,2014,34(5):529
[8] LI B,LI Y,TIAN S,et al.Anti-inflammatory effects of perioperative dexmedetomidine administered as an adjunct to general anesthesia:a meta-analysis[J].Sci Rep,2015,5:12342
[9] GOUIN JP,KIECOLT-GLASER JK.The impact of psychological stress on wound healing: methods and mechanisms[J].Immunol Allergy Clin North Am,2011,31(1):81
[10]EMING SA,KRIEG T,DAVIDSON JM.Inflammation in wound repair:molecular and cellular mechanisms[J].J Invest Dermatol,2007,127(3):514

相似文献/References:

[1]李廷坤,汪蕾,孙亚林,等.右美托咪定对丙泊酚全麻患者恢复期脑电双频指数和血流动力学的影响*[J].郑州大学学报(医学版),2015,(01):107.
 LI Tingkun,WANG Lei,SUN Yalin,et al.Effect of dexmedetomidine on bispectral index and haemodynamics during propofol anesthesia recovery period[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(03):107.
[2]杨现会△,吕淼淼,付红光,等.异丙酚复合右美托咪定麻醉对术中知晓和术后记忆的影响[J].郑州大学学报(医学版),2015,(05):692.
 YANG Xianhui,LV Miaomiao,FU Hongguang,et al.Influence of propofol combined with dexmedetomidine on intraoperative awareness and postoperative memory[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2015,(03):692.
[3]汪业铭),李树铁),高 艳),等.右美托咪定对PC12细胞氧糖剥夺损伤的保护作用[J].郑州大学学报(医学版),2019,(04):611.[doi:10.13705/j.issn.1671-6825.2018.11.054]
 WANG Yeming),LI Shutie),GAO Yan),et al.Protective effects of dexmedetomidine on P12 cells following oxygen-glucose deprivation injury[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2019,(03):611.[doi:10.13705/j.issn.1671-6825.2018.11.054]

备注/Memo

备注/Memo:
#通信作者,女,1962年7月生,硕士,主任医师,研究方向:麻醉学,E-mail:chengjinglin@163.com
更新日期/Last Update: 2016-05-20