[1]侯 梦),刘 蓉),廖海星),等.西地那非对西藏小型猪慢性肺动脉高压模型体循环压力的影响*[J].郑州大学学报(医学版),2016,(05):610-613.
 HOU Meng),LIU Rong),LIAO Haixing),et al.Effects of sildenafil on systemic blood pressure in Tibet minipigs with chronic pulmonary hypertension[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(05):610-613.
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西地那非对西藏小型猪慢性肺动脉高压模型体循环压力的影响*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年05期
页码:
610-613
栏目:
应用研究
出版日期:
2016-08-20

文章信息/Info

Title:
Effects of sildenafil on systemic blood pressure in Tibet minipigs with chronic pulmonary hypertension
作者:
侯 梦12)刘 蓉12)廖海星1)汪延生12)岳 敏3)张新凤1)吴清洪3)李洪涛12)#顾为望3)
1)广州医科大学附属第一医院广州呼吸疾病研究所 广州 510120;2)呼吸疾病国家重点实验室 广州 510230;3)南方医科大学实验动物中心 广州 510515
Author(s):
HOU Meng12)LIU Rong12)LIAO Haixing1)WANG Yansheng12)YUE Min3)ZHANG Xinfeng1)WU Qinghong3)LI Hongtao12)GU Weiwang3)
1)Guangzhou Institute of Respiratory Diseases,the Affiliated First Hospital, Guangzhou Medical University, Guangzhou 510120;2)The State Key Laboratory of Respiratory Diseases,Guangzhou 510230;3)Laboratory Animal Centre, Southern Medical University, Guangzhou 510515
关键词:
西地那非 肺动脉高压 西藏小型猪 体循环血压
Keywords:
sildenafil pulmonary hypertension Tibet minipig systemic blood pressure
分类号:
R543.2
摘要:
目的:观察西地那非对西藏小型猪慢性肺动脉高压(PH)模型体循环压力的影响。方法:18头2月龄西藏小型猪随机分为正常对照组、模型组和治疗组,每组6头。模型组和治疗组小型猪腹腔注射野百合碱42 d用以制备PH模型,正常对照组给予相同剂量溶剂。第42天,超声心动图扫查估算肺动脉压。第43天开始,治疗组喂食西地那非(6.0 mg·kg-1·d-1),共21 d。第64天超声心动图扫查估算动物肺动脉压,左颈动脉插管测定体循环压力。结果:与对照组比较,模型组肺动脉压和体循环压力均明显升高(P<0.05); 与模型组相比,治疗组肺动脉压均降低,同时体循环压力亦明显下降,甚至低于正常对照组(P<0.05)。结论:西地那非在降低肺动脉压的同时也降低体循环压力。
Abstract:
Aim: To investigate the effects of sildenafil on the systemic blood pressure of Tibet minipig models with chronic pulmonary hypertension(PH).Methods: A total of 18 Tibet minipigs were randomly allocated into control group, model group and treatment group, 6 in each group. The Tibet minipigs in model group and treatment group were treated with monocrotaline(MCT)for 42 d to establish PH model.Since day 43, the treatment group was treated with sidenafil(6.0 mg·kg-1·d-1)for 3 weeks. Conventional transthoracic echocardiography was performed at day 42 and day 64.The systemic blood pressure was measured by left carotid artery cannulation linked to a MedLab biological signal collecting and processing system at day 64.Results: At day 64, pulmonary artery pressure and systemic blood pressure of the model group were higher than those of control group(P<0.05); pulmonary artery pressure and systemic blood pressure of the treatment group were lower than those of the model group(P<0.05), and systemic blood pressure was even lower than that of control group(P<0.05).Conclusion: Sildenafil could reduce pulmonary artery pressure, at the same time, also reduce systemic pressure.

参考文献/References:

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备注/Memo

备注/Memo:
*广东省科研基础条件建设项目 2012B060300032
#通信作者, 男, 1964年10月生, 博士,教授, 研究方向:呼吸病理生理学、比较医学, E-mail:gyhongtao@126.com
更新日期/Last Update: 2016-08-20