[1]宋雅信,赵晓燕#,王小芳,等.中性粒细胞-淋巴细胞比值及D-二聚体与急性冠脉综合征冠脉狭窄程度的关系*[J].郑州大学学报(医学版),2016,(06):780-784.
 SONG Yaxin,ZHAO Xiaoyan,WANG Xiaofang,et al.Relationship between neutrophils to lymphocyte ratio, D-dimer and coronary artery stenosis degree in patients with acute coronary syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(06):780-784.
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中性粒细胞-淋巴细胞比值及D-二聚体与急性冠脉综合征冠脉狭窄程度的关系*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年06期
页码:
780-784
栏目:
应用研究
出版日期:
2016-11-20

文章信息/Info

Title:
Relationship between neutrophils to lymphocyte ratio, D-dimer and coronary artery stenosis degree in patients with acute coronary syndrome
作者:
宋雅信赵晓燕#王小芳魏 静
郑州大学第一附属医院心内科 郑州 450052
Author(s):
SONG YaxinZHAO XiaoyanWANG XiaofangWEI Jing
Department of Cardiology,the First Affiliated Hospital,Zhengzhou Universty,Zhengzhou 450052
关键词:
中性粒细胞-淋巴细胞比值 D-二聚体 急性冠脉综合征 Gensini评分 冠脉狭窄程度
Keywords:
neutrophils to lymphocyte ratio D-dimer acute coronary syndrome Gensini score coronary artery stenosis degree
分类号:
R541.4
摘要:
目的:观察急性冠脉综合征患者中性粒细胞-淋巴细胞比值(NLR)及血清D-二聚体的水平变化,并探讨两者与急性冠脉综合征(ACS)病变血管狭窄程度的相关性。方法:收集符合ACS诊断标准的患者230例,根据症状及检查结果分为不稳定心绞痛组(n=131)、急性心肌梗死组(n=99),并行冠脉造影明确血管病变。选取同期造影结果正常患者59例作为对照组。计算NLR,检测血清D-二聚体水平,分析NLR及D-二聚体与Gensini评分的关系。结果:AMI组NLR、D-二聚体明显高于对照组及UAP组(P<0.05); UAP组D-二聚体明显高于对照组(P<0.05)。AMI组患者NLR、D-二聚体水平与冠状动脉狭窄程度呈正相关(r=0.618和0.489,P<0.001)。结论:NLR及D-二聚体水平与急性冠脉综合征冠脉狭窄程度有关,并对病情严重程度具有提示意义。
Abstract:
Aim: To observe the changes of neutrophils to lymphocyte ratio(NLR)and D-dimer in patients with acute coronary syndrome(ACS), and to analyze the relationship between NLR,D-dimer and coronary artery stenosis degree.Methods: A total of 230 patients with ACS were allocated into unstable angina pectoris(UAP)group(n=131)and acute myocardial infarction(AMI)group(n=99).Patients(n=59)with normal coronary arteriograms were selected as control.Then the relationship between NLR and D-dimer and Gensini scores of coronary stenosis were analyzed.Results: In AMI group,the levels of NLR and D-dimer were significantly higher than those in UAP group and control group(P<0.05); in UAP group,the levels of D-dimer was significantly higher than that in control group(P<0.05). NLR and D-dimer were positively correlated with the degree of coronary artery stenosis(r=0.618 and 0.489,P<0.001).Conclusion: NLR and D-dimer are positively correlated with the degree of coronary artery stenosis, and have a prognostic significance in assessing coronary artery stenosis degree.

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备注/Memo

备注/Memo:
*河南省医学科技攻关计划项目 201403015; 河南省高等学校重点科研项目计划 16A320029
#通信作者,女,1972年9月生,博士,副主任医师,研究方向:心血管病介入治疗、高血压,E-mail:xyz6652@163.com
更新日期/Last Update: 2016-11-20