[1]宋 毅),程敬亮)#,郑 权),等.实时剪切波超声弹性成像对肝脏局灶性结节性增生及肝腺瘤的鉴别诊断[J].郑州大学学报(医学版),2016,(06):784-787.
 SONG Yi),CHENG Jingliang),ZHENG Quan),et al.Clinical research of real time shear wave elastography in differential diagnosis of focal nodular hyperplasia and hepatocellular adenoma[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(06):784-787.
点击复制

实时剪切波超声弹性成像对肝脏局灶性结节性增生及肝腺瘤的鉴别诊断()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年06期
页码:
784-787
栏目:
应用研究
出版日期:
2016-11-20

文章信息/Info

Title:
Clinical research of real time shear wave elastography in differential diagnosis of focal nodular hyperplasia and hepatocellular adenoma
作者:
宋 毅1)程敬亮2)#郑 权1)孙璐璐1)霍婷婷1)
1)郑州大学第一附属医院超声科 郑州 450052;
2)郑州大学第一附属医院磁共振科 郑州 450052
Author(s):
SONG Yi1) CHENG Jingliang2) ZHENG Quan1) SUN Lulu1) HUO Tingting1)
1)Department of Ultrasound, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;
2)Department of Magnetic Resonance Imaging, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
剪切波超声弹性成像 杨氏模量 ROC曲线
Keywords:
shear wave elastography Young's modulus ROC curve
分类号:
R445.1
摘要:
目的:研究肝脏局灶性结节性增生(FNH)和肝腺瘤(HA)的实时剪切波超声弹性成像(SWE)声像图特点,探讨SWE在FNH和HA鉴别诊断中的临床应用价值。方法:选取34个FNH及12个HA的肝脏占位性病变,行SWE检查,获取病变的杨氏模量平均值、病变与邻近肝组织杨氏模量平均值的比值(杨氏模量比值),所有病变均以病理检查结果为金标准,对SWE鉴别诊断FNH和HA的准确性进行评价。结果:FNH组杨氏模量平均值为(40.56±13.37)kPa,HA组为(14.33±7.81)kPa; FNH组杨氏模量比值为(6.42±2.13),HA组为(2.45±1.61); FNH组与HA组比较,差异均有统计学意义(P均<0.001)。通过ROC曲线确定FNH和HA杨氏模量平均值的临界点为14.45 kPa,其敏感度97.1%、特异性93.3%,曲线下面积为96.1%; 杨氏模量比值的临界点为6.32,其敏感度98.2%、特异性67.4%,曲线下面积为97.2%。结论:SWE在FNH及HA鉴别诊断中具有重要临床价值。
Abstract:
Aim: To evaluate the sonographic features of real-time shear wave elastography(SWE)in patients with focal nodular hyperplasia(FNH)and hepatocellular adenoma(HA)and investigate the clinical application value of SWE in differential diagnosis of FNH and HA.Methods: There were 34 cases in the FNH group and 12 cases in the HA group in the study. All the cases were performed SWE, the mean elasticity of Young's modulus of the lesions and the ratio of the mean elasticity of Young's modulus of the lesions to that of the surrounding liver(the ratio of the mean elasticity of Young's modulus)were obtained. All the lesions were confirmed by pathologies as the gold standard. SWE results were compared with the pathologies to evaluate the accuracy using SWE to diagnose the FNH and HA.Results: The mean elasticity of Young's modulus of the lesions was(40.56±13.37)kPa in FNH group and(14.33±7.81)kPa in HA group. The ratio of the mean elasticity of Young's modulus was(6.42±2.13)in FNH group and(2.45±1.61)in HA group. The mean elasticity of Young's modulus of the lesions and the ratio of the mean elasticity of Young's modulus had significant difference between FNH and HA groups(P<0.001). The critical point of the mean elasticity of Young's modulus of the lesions between FNH and HA was 14.45 kPa by ROC curve, the sensitivity was 97.1%, and specificity was 93.3%. The area under the ROC curve of FNH and HA was 96.1%. The critical point of the ratio of the mean elasticity of Young's modulus was 6.32 by ROC curve, the sensitivity was 98.2%, and specificity was 67.4%.The area under the ROC curve was 97.2%.Conclusion: SWE has an important value of clinical application in diagnosis between FNH and HA.

参考文献/References:

[1] MAILLETTE DE BUY WENNIGER L,TERPSTRA V,BEUERS U.Focal nodular hyperplasia and hepatic adenoma: epidemiology and pathology[J].Dig Surg,2010,27(1):24
[2] DARDENNE S,HUBERT C,SEMPOUX C,et al.Conservative and operative management of benign solid hepatic tumours: a successful stratified algorithm[J].Eur J Gastroenterol Hepatol,2010,22(11):1337
[3] BUELL JF, TRANCHART H, CANNON R,et al.Management of benign hepatic tumors[J].Surg Clin North Am,2010,90(4):719
[4] CHOI BY,NGUYEN MH.The diagnosis and management of benign hepatic tumors[J].J Clin Gastroenterol,2005,39(5):401
[5] BRUNEL T,GUIBAL A,BOULARAN C,et al.Focal nodular hyperplasia and hepatocellular adenoma:the value of shear wave elastography for differential diagnosis[J].Eur J Radiol,2015,84(11):2059
[6] 李兴华,周平,王利华,等.超声造影对肝局灶性结节增生与肝腺瘤的鉴别诊断[J].中国超声医学杂志,2010,26(9):847
[7] PARK HS,KIM YJ,YU MH,et al.Shear wave elastography of focal liver lesion:intraobserver reproducibility and elasticity characterization[J].Ultrasound Q,2015,31(4):262
[8] 刘洋,叶春风.血清铁蛋白在儿童系统性红斑狼疮的诊断价值及判断病情活动的意义[J].实用儿科临床杂志,2012,27(21):1647
[9] 张艳,刘锋,陈洋,等.下肢深静脉血栓病程的实时剪切波弹性成像技术评价[J].郑州大学学报(医学版),2014,49(4):585
[10]RONOT M,DI RENZO S,GREGOLI B,et al.Characterization of fortuitously discovered focal liver lesions: additional information provided by shearwave elastography[J].Eur Radiol,2015,25(2):346
[11]GUIBAL A,BOULARAN C,BRUCE M,et al.Evaluation of shearwave elastography for the characterisation of focal liver lesions on ultrasound[J].Eur Radiol,2013,23(4):1138
[12]GALLOTTI A,D'ONOFRIO M,ROMANINI L,et al.Acoustic radiation force impulse(ARFI)ultrasound imaging of solid focal liver lesions[J].Eur J Radiol,2012,81(3):451
[13]HEIDE R,STROBEL D,BERNATIK T,et al.Characterization of focal liver lesions(FLL)with acoustic radiation force impulse(ARFI)elastometry[J].Ultraschall Med,2010,31(4):405
[14]ZUCMAN-ROSSI J,JEANNOT E,VAN NHIEU JT,et al.Genotype-phenotype correlation in hepatocellular adenoma:new classification and relationship with HCC[J].Hepatology,2006,43(3):515

相似文献/References:

[1]宋 毅,程敬亮#,郑 权,等.实时剪切波超声弹性成像对肝血管瘤与肝细胞性肝癌的鉴别诊断价值*[J].郑州大学学报(医学版),2017,(02):221.[doi:10.13705/j.issn.1671-6825.2017.02.029]

备注/Memo

备注/Memo:
#通信作者,男,1964年8月生,博士,主任医师,研究方向:神经系统及腹部疾病的影像学诊断,E-mail:cjl.chjl@vip.163.com
更新日期/Last Update: 2016-11-20