[1]丁素英),刘东伟),安 璐)#,等.郑州市体检人群慢性肾脏病危险因素分析[J].郑州大学学报(医学版),2016,(06):787-791.
 DING Suying),LIU Dongwei),AN Lu),et al.Risk factors analysis of chronic kidney disease in physical examination population in Zhengzhou[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2016,(06):787-791.
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郑州市体检人群慢性肾脏病危险因素分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2016年06期
页码:
787-791
栏目:
应用研究
出版日期:
2016-11-20

文章信息/Info

Title:
Risk factors analysis of chronic kidney disease in physical examination population in Zhengzhou
作者:
丁素英1)刘东伟2)安 璐1)#李飞飞1)
1)郑州大学第一附属医院体检科 郑州 450052;
2)郑州大学第一附属医院肾脏内科 郑州 450052
Author(s):
DING Suying1)LIU Dongwei2)AN Lu1)LI Feifei1)
1)Medical Examination Center, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052;
2)Department of Nephrology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052
关键词:
慢性肾脏病 尿白蛋白/肌酐 肾小球滤过率 危险因素 郑州市
Keywords:
chronic kidney disease urinary albumin/creatinine glomerular filtration rate risk factor Zhengzhou City
分类号:
R195.1
摘要:
目的:探讨体检人群慢性肾脏病(CKD)的危险因素。方法:搜集2013年2月至2015年5月在郑州大学第一附属医院体检科定期体检、年龄20~80岁的3 750人为研究对象,分析相关危险因素如性别、年龄、BMI、吸烟、高血压、糖尿病、高脂血症对CKD肾损伤指标的影响。结果:研究人群总体白蛋白尿检出率为8.8%(329/3 750),肾功能减退检出率为2.8%(105/3 750)。不同性别、年龄、BMI、高血压、糖尿病、高脂血症人群白蛋白尿和肾功能减退检出率比较,差异均有统计意义(P<0.05); logistic回归分析显示,性别(男性)、BMI、高血压、糖尿病、高脂血症是白蛋白尿发生的独立危险因素,其OR(95%CI)分别为1.567(1.329~1.847)、1.255(1.129~1.395)、1.939(1.584~2.372)、2.370(1.888~2.975)、1.293(1.099~1.521); 年龄、高血压、糖尿病、高脂血症是肾功能减退的独立危险因素,其OR(95%CI)分别为1.970(1.379~2.814)、1.654(1.218~2.245)、1.394(1.072~1.812)、1.929(1.369~2.718)。结论:早期识别体检人群中增加CKD风险的危险因素,并积极及时给予综合防治,对于降低CKD发病率、规范CKD健康管理具有非常重要的意义。
Abstract:
Aim: To discuss the risk factors of chronic kidney disease(CKD)in physical examination population in Zhengzhou.Methods: A total of 3 750 cases of physical examination population, aged 20 to 80 years, who accepted regular medical checkup in the First Affiliated Hospital of Zhengzhou University between February 2013 to May 2015 were collected as the research objects.Relevant risk factors, such as gender, age, BMI, smoking, hypertension, diabetes and hyperlipemia were analyzed.Results: The overall albumin urine detection rate was 8.8%(329/3 750), renal function decrease detection rate was 2.8%(105/3 750). There were significant differences in albumin urine detection rate and renal function decrease detection rate between different gender, age, BMI, hypertension, diabetes, or hyperlipidemia groups(P<0.05). Multiple logistic regression analysis showed that gender(male), BMI, hypertension, diabetes, and hyperlipidemia were independent risk factors for the development of albuminuria, the OR(95%CI) were 1.567(1.329-1.847), 1.255(1.129-1.395), 1.939(1.584-2.372), 2.370(1.888-2.975), 1.293(1.099-1.521), respectively; age, hypertension, diabetes, and hyperlipidemia were independent risk factor for renal function decrease, and the OR(95%CI) were 1.970(1.379-2.814), 1.654(1.218-2.245), 1.394(1.072-1.812), 1.929(1.369-2.718), respectively.Conclusion: Early recognition the risk factors that could increase the risk of CKD in physical examination crowd, and taking measures to comprehensive prevent and cure, which is of great value of reducing the incidence and standardizing health management of CKD.

参考文献/References:

[1] ZHANG L,WANG F,WANG L,et al.Prevalence of chronic kidney disease in China: a cross-sectional survey[J].Lancet,2012,379(9818):815
[2] WANG Y,ZHAO D,XING Y,et al.Clinical features of Chinese coronary heart disease patients with chronic kidney disease[J].Ren Fail,2012,34(8):985
[3] SHANKAR A,LENG C,CHIA KS,et al.Association between body mass index and chronic kidney disease in men and women: population-based study of Malay adults in Singapore[J].Nephrol Dial Transplant,2008,23(6):1910
[4] MA YC,ZUO L,CHEN JH,et al.Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease[J].J Am Soc Nephrol,2006,17(10):2937
[5] 王吉耀.内科学[M].2版.北京:人民卫生出版社,2010:667
[6] HUANG X,SUI X,RUIZ JR,et al.Parental history of premature cardiovascular disease, estimated GFR, and rate of estimated GFR decline:results from the Aerobics center longitudinal study[J].Am J Kidney Dis,2015,65(5):692
[7] 郭晶,杨金奎.微量白蛋白尿对2型糖尿病患者出现终末期肾病的预测作用研究[J].首都医科大学学报,2014,35(1):60
[8] HALLAN SI,DAHL K,OIEN CM,et al.Screening strategies for chronic kidney disease in the general population: follow-up of cross sectional health survey[J].BMJ,2006,333(7577):1047
[9] ISEKI K,IKEMIYA Y,ISEKI C,et al.Proteinuria and the risk of developing end-stage renal disease[J].Kidney Int,2003,63(4):1468
[10]温继兰,王凤仙,李秉程,等.山西省右玉县城镇成人慢性肾脏病的流行病学研究[J].中华肾脏病杂志,2010,26(2):99
[11]COLLINS AJ,FOLEY RN,CHAVERS B,et al.US renal data system 2013 annual data report[J].Am J Kidney Dis,2014,63(1 Suppl):A7
[12]WAKASUGI M,NARITA I,ISEKI K,et al.Weight gain after 20 years of age is associated with prevalence of chronic kidney disease[J].Clin Exp Nephrol,2012,16(2):259
[13]李秀梅.健康体检者慢性肾脏病患病率及危险因素探讨[J].中国卫生标准管理,2015,20(6):4
[14]王德光,郝丽,戴宏,等.安徽省成人慢性肾脏病流行病学调查[J].中华肾脏病杂志,2012,28(2):101
[15]李晶,李毅,王效增,等.心功能不全对糖尿病合并肾功能不全患者发生对比剂所致急性肾功能损害的影响[J].解放军医学杂志,2015,40(9):727
[16]TAMURA K,YUTOH J,MATSUSHITA K,et al.Hypertension with chronic kidney disease: anti-hypertensive therapy recommended for the management of hypertension with CKD in JSN-CKD GL 2013 and JSH2014[J].Nihon Rinsho,2015,73(11):1876
[17]王凡,叶平,肖文凯,等.北京部分地区人群心血管疾病危险因素与慢性肾脏病的相关性分析[J].中华流行病学杂志,2010,31(3):256

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备注/Memo

备注/Memo:
#通信作者,女,1963年11月生,本科,副主任医师,研究方向:健康管理,E-mail:anlu1127@163.com
更新日期/Last Update: 2016-11-20