[1]董慧君△,董小方,王 敏,等.促胃肠动力药提高鼻肠管幽门后置管成功率的网状meta分析[J].郑州大学学报(医学版),2017,(01):58-63.[doi:10.13705/j.issn.1671-6825.2017.01.016]
 DONG Huijun,DONG Xiaofang,WANG Min,et al.Prokinetic agent for promoting post-pyloric placement of naso-enteral feeding tubes: a network meta-analysis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(01):58-63.[doi:10.13705/j.issn.1671-6825.2017.01.016]
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促胃肠动力药提高鼻肠管幽门后置管成功率的网状meta分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年01期
页码:
58-63
栏目:
应用研究
出版日期:
2017-01-15

文章信息/Info

Title:
Prokinetic agent for promoting post-pyloric placement of naso-enteral feeding tubes: a network meta-analysis
作者:
董慧君董小方王 敏董洄羽
郑州人民医院重症医学科 郑州 450003
Author(s):
DONG Huijun DONG Xiaofang WANG Min DONG Huiyu
Department of Critical Care Unit, Zhengzhou People's Hospital, Zhengzhou 450003
关键词:
甲氧氯普胺 红霉素 多潘立酮 促胃肠动力药 幽门后置管 网状meta分析
Keywords:
metoclopramide erythromycin domperidone prokinetic agent post-pyloric placement network meta-analysis
分类号:
R975.1
DOI:
10.13705/j.issn.1671-6825.2017.01.016
摘要:
目的:采用网状meta分析的方法比较甲氧氯普胺、红霉素和多潘立酮3种促胃肠动力药提高鼻肠管幽门后置管成功率的有效性。方法:计算机检索Cochrane Central Register of Controlled Trials、PubMed、EMBASE、OVID、Web of Science、中国知网和万方数据库,检索时限为从各数据库建库至2015年10月。按纳入和排除标准进行文献筛选、资料提取及meta分析。结果:共纳入11篇文献,共计802例患者。直接meta分析结果显示,甲氧氯普胺(OR=2.37, 95%CI=1.64~3.42, P<0.001)、红霉素(OR=3.45, 95%CI=2.05~5.81, P<0.001)、多潘立酮(OR=3.62,95%CI=2.00~6.56, P<0.001)在提高幽门后置管成功率方面疗效均优于安慰剂。排序概率图显示,红霉素效果最佳,其次是甲氧氯普胺和多潘立酮。结论:在提高鼻肠管幽门后置管成功率的促胃肠动力药中,红霉素的效果优于甲氧氯普胺和多潘立酮。
Abstract:
Aim: To evaluate the effectiveness and safety of 3 prokinetic agents(metoclopramide,erythromycin, and domperidone)for post-pyloric placement of naso-enteral feeding tubes.Methods: Cochrane Central Register of Controlled Trials, PubMed, EMBASE, OVID, Web of Science, CNKI and Wanfang Data were searched from their inception to October 2015. Literature selection, data extraction and meta-analysis were conducted according to inclusion criteria and exclusion criteria.Results: Eleven trials involving 802 patients fed via naso-enteral feeding tubes were identified. The direct meta-analysis showed that compared with placebo or no intervention, metoclopramide(OR=2.37, 95%CI=1.64-3.42, P<0.001), erythromycin(OR=3.45, 95%CI=2.05-5.81, P<0.001)and domperidone(OR=3.62, 95%CI=2.00-6.56, P<0.001)could increase successful rate of post-pyloric placement of naso-enteral feeding tubes. The rank probability plot showed that the success rate of erythromycin was the highest and then metoclopramide and domperidone in a descending order.Conclusion: Among 3 prokinetic agents, erythromycin is superior to the other 2 in success rate of post-pyloric placement of naso-enteral feeding tubes.

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备注/Memo

备注/Memo:
△女,1982年2月生,本科,护师,研究方向:重症患者管理,E-mail:donghuijun450012@sina.com
更新日期/Last Update: 2017-01-20