[1]高延秋)△,张 华),李双凤),等.血浆可溶性血管内皮生长因子受体1在重症肺炎患者中的诊断与预测价值*[J].郑州大学学报(医学版),2017,(01):63-67.[doi:10.13705/j.issn.1671-6825.2017.01.017]
 GAO Yanqiu),ZHANG Hua),LI Shuangfeng),et al.Diagnosis and predictive value of plasma soluble vascular endothelial growth factor receptor-1 in patients with severe pneumonia[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(01):63-67.[doi:10.13705/j.issn.1671-6825.2017.01.017]
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血浆可溶性血管内皮生长因子受体1在重症肺炎患者中的诊断与预测价值*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年01期
页码:
63-67
栏目:
应用研究
出版日期:
2017-01-15

文章信息/Info

Title:
Diagnosis and predictive value of plasma soluble vascular endothelial growth factor receptor-1 in patients with severe pneumonia
作者:
高延秋1)△张 华2)李双凤1)董 睿1)李振华1)任英杰1)
1)郑州大学附属郑州中心医院呼吸重症医学科 郑州 450007;
2)郑州大学附属郑州中心医院呼吸内科 郑州 450007
Author(s):
GAO Yanqiu1)ZHANG Hua2)LI Shuangfeng1)DONG Rui1)LI Zhenhua1)REN Yingjie1)
1)Respiratory Intensive Care Unit,Affiliated Zhengzhou Central Hospital, Zhengzhou University,Zhengzhou 450007;
2)Department of Respiratory Medicine,Affiliated Zhengzhou Central Hospital, Zhengzhou University,Zhengzhou 450007
关键词:
血浆可溶性血管内皮生长因子受体1 重症肺炎 预测价值
Keywords:
plasma soluble vascular endothelial growth factor receptor-1 severe pneumonia predictive value
分类号:
R563.1
DOI:
10.13705/j.issn.1671-6825.2017.01.017
摘要:
目的:探讨血浆可溶性血管内皮生长因子受体1(sFLT-1)在重症肺炎患者中的变化及预测价值。方法:选取2013年10月至2016年4月入住郑州大学附属郑州中心医院呼吸重症医学科的重症肺炎患者60例(A组)、重症肺炎合并感染性休克患者60例(B组)、重症肺炎合并MODS患者60例(C组),选取同期入住呼吸内科的社区获得性肺炎患者60例作为对照组(D组)。比较各组患者入院第1、3、7天以及存活组(n=96)和死亡组(n=84)sFLT-1水平变化,分析血浆sFLT-1在重症肺炎中的预测价值及与APACHEⅡ评分的相关性。结果:4组患者PCT和APACHE Ⅱ评分比较,差异有统计学意义(P均<0.05)。A、B、C 3组患者血浆sFLT-1水平比较,差异有统计学意义,且A、B、C 3组第7天均低于第1天(P均<0.05)。重症肺炎死亡组sFLT-1水平高于存活组(P<0.001)。重症肺炎患者sFLT-1水平和APACHE Ⅱ评分有关(r=0.647,P<0.001)。sFLT-1预测重症肺炎和28 d病死率的敏感度及特异度分别为77.8%、75.0%和69.7%、80.1%,AUC分别为 0.787(95%CI=72.6%~84.8%,P<0.001)和0.775(95%CI=70.5%~84.5%,P<0.001)。结论:血浆sFLT-1水平可以预测重症肺炎和28 d病死率。
Abstract:
Aim: To explore the diagnosis and predictive value of plasma soluble vascular endothelial growth factor receptor-1(sFLT-1)in patients with severe pneumonia.Methods: A total of 60 patients with severe pneumonia(group A),60 patients with severe pneumonia-related septic shock(group B)and 60 patients with severe pneumonia-related MODS(group C)in RICU of Affiliated Zhengzhou Central Hospital of Zhengzhou University were admitted from October 2013 to April 2016 in the study. Sixty cases of common community-acquired pneumonia in Department of Respiratory Medicine were included for comparison(group D). Plasma sFLT-1 was measured on the 1st,3rd and 7th day respectively. The association of sFLT-1 with APACHE Ⅱ score and predictive value of sFLT-1 for severe pneumonia were analyzed.Results: The differences were significant in the levels of PCT and APACHE Ⅱ score among the 4 groups(P<0.05).There were significant differences in plasma sFLT-1 among group A,B and C, and sFLT-1 was the lowest on the 7th day in group A,B and C(P<0.05). Non-survivors of severe pneumonia had higher plasma sFLT-1 levels than survivors(P<0.001). Plasma sFLT-1 level correlated with the APACHE Ⅱscore(r=0.647,P<0.001). sFLT-1 was used for diagnosis of severe pneumonia and predict the mortality for 28 d,and the sensitivity and the specificity was 77.8%,75.0% and 69.7%,80.1%,respectively. AUC was 0.787(95%CI=72.6%-84.8%,P<0.001)and 0.775(95%CI=70.5%-84.5%,P<0.001),respectively.Conclusion: Plasma sFLT-1 level could predict severe pneumonia and mortality for 28 d.

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备注/Memo

备注/Memo:
*河南省医学科技攻关项目 201503210
△女,1972年11月生,硕士,主任医师,研究方向:呼吸与危重症,E-mail:drgaoyanqiu@126.com
更新日期/Last Update: 2017-01-20