[1]李 恩),汪 涛),张丽华),等.急性冠脉综合征患者血清miRNA-208与血小板功能的关系*[J].郑州大学学报(医学版),2017,(02):188-190.[doi:10.13705/j.issn.1671-6825.2017.02.020]
 LI En),WANG Tao),ZHANG Lihua),et al.Relationship between serum miRNA-208 and platelet function in patients with acute coronary syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(02):188-190.[doi:10.13705/j.issn.1671-6825.2017.02.020]
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急性冠脉综合征患者血清miRNA-208与血小板功能的关系*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年02期
页码:
188-190
栏目:
应用研究
出版日期:
2017-03-15

文章信息/Info

Title:
Relationship between serum miRNA-208 and platelet function in patients with acute coronary syndrome
作者:
李 恩1)汪 涛2)张丽华1)简立国1)孙利强1)牛少辉1)#
1)郑州大学第二附属医院心血管内科 郑州 450014
2)郑州大学第二附属医院干部病房 郑州 450014
Author(s):
LI En1)WANG Tao2)ZHANG Lihua1)JIAN Liguo1)SUN Liqiang1)NIU Shaohui1)
1)Department of Cardiovascular Internal Medicine,the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
2)Cadre Ward,the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
急性冠脉综合征 miRNA-208 血小板分布宽度 平均血小板体积
Keywords:
acute coronary syndrome miRNA-208 platelet distribution width mean platelet volume
分类号:
R541.4
DOI:
10.13705/j.issn.1671-6825.2017.02.020
摘要:
目的:探讨急性冠脉综合征(ACS)患者血清miRNA-208与血小板功能的关系。方法:选取2014年1月至2015年9月郑州大学第二附属医院收治的ACS患者60例(ACS组)和非ACS患者20例(对照组),根据诊断结果将ACS组进一步分为心肌梗死组(n=32)和不稳定心绞痛组(n=28)。入院即刻对3组患者进行静脉血液采集,测定血小板计数(PLT)、血小板分布宽度(PDW)及平均血小板体积(MPV); 利用实时荧光定量PCR法测定血清miRNA-208。结果:与对照组比较,心肌梗死组和不稳定心绞痛组血清miRNA-208、PDW、MPV升高,差异有统计学意义(P<0.05)。与不稳定心绞痛组比较,心肌梗死组血清miRNA-208、PDW、MPV升高,差异有统计学意义(P<0.05)。ACS患者血清miRNA-208与PDW和MPV呈正相关(r=0.828、0.766,P<0.05)。结论:ACS患者血清miRNA-208与血小板活化密切相关, miRNA-208参与了血小板活化的调控。
Abstract:
Aim: To investigate the relationship between serum miRNA-208 and platelet function in patients with acute coronary syndrome(ACS).Methods: A total of 60 cases of ACS(ACS group)and 20 cases of non-ACS(control group)were collected,and the ACS group was further allocated into myocardial infarction group(AMI group, n=32)and unstable angina pectoris group(UA group, n=28). Platelet(PLT), platelet distribution width(PDW)and mean platelet volume(MPV)were measured. The serum miRNA-208 was measured by real-time fluorescence quantitative PCR method.Results: Compared with control group, the serum level of miRNA-208, PDW and MPV were significantly higher in the AMI group and the UA group(P<0.05).Compared with the UA group, the serum level of miRNA-208, PDW, MPV were significantly higher in the AMI group(P<0.05). In patients with ACS, the serum level of miRNA-208 was correlated with PDW and MPV(r=0.828,0.766,P<0.05).Conclusion: miRNA-208 is closely related to platelet activation and involves in the regulation of platelet activation in patients with ACS.

参考文献/References:

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备注/Memo

备注/Memo:
*郑州市普通科技攻关计划项目 141PPTGG453; 河南省高等学校重点科研项目 15A320019
#通信作者,男,1977年11月生,硕士,副主任医师,研究方向:冠心病的预防与治疗,E-mail:ln1025asdfgh@sohu.com
更新日期/Last Update: 2017-03-20