[1]朱艺伟),姚明解),薄亚聪),等.淋巴细胞与单核细胞比值对原发性肝癌患者根治性切除术后预后的预测价值*[J].郑州大学学报(医学版),2017,(02):197-200.[doi:10.13705/j.issn.1671-6825.2017.02.023]
 ZHU Yiwei),YAO Mingjie),BO Yacong),et al.Prognostic assessment of lymphocyte-to-monocyte ratio for patients with primary liver cancer after curative hepatectomy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(02):197-200.[doi:10.13705/j.issn.1671-6825.2017.02.023]
点击复制

淋巴细胞与单核细胞比值对原发性肝癌患者根治性切除术后预后的预测价值*()
分享到:

《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年02期
页码:
197-200
栏目:
应用研究
出版日期:
2017-03-15

文章信息/Info

Title:
Prognostic assessment of lymphocyte-to-monocyte ratio for patients with primary liver cancer after curative hepatectomy
作者:
朱艺伟1)姚明解2)薄亚聪1)游 杰1)崔 晗1)张 玲3)赵二江4)吕全军1)#
1)郑州大学公共卫生学院营养与食品卫生学教研室 郑州 450001
2)北京大学基础医学院病原生物学系 北京100191
3)郑州大学附属肿瘤医院; 河南省肿瘤医院肝胆外科 郑州 450003
4)郑州大学附属肿瘤医院病案室 郑州 450003
Author(s):
ZHU Yiwei1) YAO Mingjie2) BO Yacong1) YOU Jie1) CUI Han1) ZHANG Ling3) ZHAO Erjiang4) LYU Quanjun1)
1)Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001
2)Department of Pathogenic Biology, School of Basic Medical Sciences, Peking University, Beijing 100191
3)Department of Hepatobiliary Surgery, Henan Tumor Hospital; the Affiliated Tumor Hospital, Zhengzhou University, Zhengzhou 450003
4)Department of Medical Record, the Affiliated Tumor Hospital, Zhengzhou University, Zhengzhou 450003
关键词:
淋巴细胞与单核细胞比值 原发性肝癌 预后
Keywords:
lymphocyte-to-monocyte ratio primary liver cancer prognosis
分类号:
R735.7
DOI:
10.13705/j.issn.1671-6825.2017.02.023
摘要:
目的:探讨外周血中淋巴细胞与单核细胞比值(LMR)对原发性肝癌(PLC)根治性切除术后预后的预测价值。方法:收集接受肝癌根治性切除术且术前未接受其他治疗的PLC患者447例的临床及实验室资料,根据术前外周血检查结果计算LMR,绘制术前LMR诊断患者术后5 a生存状态的ROC曲线,确定LMR诊断界值。采用Kaplan-Meier法和COX回归模型分析PLC患者术后5 a生存的影响因素。结果:术前LMR诊断界值为3.03,据此将LMR分为高(≥3.03)和低(<3.03)两种状态。COX分析结果显示术前高LMR是PLC患者术后预后的保护因素(β=-0.329,HR=0.720,95%CI=0.562~0.921)。结论:术前LMR可用于评价PLC根治性切除术后患者的预后,术前高LMR患者预后较好。
Abstract:
Aim: To investigate the prognostic value of lymphocyte-to-monocyte ratio(LMR)in primary liver cancer(PLC)patients after curative hepatectomy.Methods: Clinical and laboratory data of 447 PLC patients who were treated by curative hepatectomy were collected. None of the patients received any other treatments before surgery. LMR was calculated. The optimal cutoff was determined by receiver operating characteristics(ROC)curve analysis. Kaplan-Meier survival analysis and COX proportional hazard model were used to evaluate the influence of LMR on patients' overall survival.Results: The optimal cutoff value of LMR for survival analysis was 3.03,and all the patients were accordingly allocated into high LMR(≥3.03)group and low LMR(<3.03)group. The COX univariate and multivariate analysis showed that enhanced LMR was an independent favorable prognostic factor for overall survival(β=-0.329,HR=0.720; 95%CI=0.562-0.921).Conclusion: LMR is an independent prognostic factor for PLC patients underwent curative hepatectomy, and patients with high LMR indicate favorable overall survival.

参考文献/References:

[1] CHEN JG,ZHANG SW.Liver cancer epidemic in China: past, present and future[J].Semin Cancer Biol,2011,21(1):59
[2] JEMAL A,BRAY F,CENTER MM,et al.Global cancer statistics[J].CA Cancer J Clin,2011,61(2):69
[3] ELINAV E,NOWARSKI R,THAISS CA,et al.Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms[J].Nat Rev Cancer,2013,13(11):759
[4] LIN GN,LIU PP,LIU DY,et al.Prognostic significance of the pre-chemotherapy lymphocyte-to-monocyte ratio in patients with previously untreated metastatic colorectal cancer receiving FOLFOX chemotherapy[J].Chin J Cancer,2016,35(1):5
[5] OZAWA T,ISHIHARA S,KAWAI K,et al.Impact of a lymphocyte to monocyte ratio in stage Ⅳ colorectal cancer[J].J Surg Res,2015,199(2):386
[6] LIN GN,PENG JW,LIU DY,et al.Increased lymphocyte to monocyte ratio is associated with better prognosis in patients with newly diagnosed metastatic nasopharyngeal carcinoma receiving chemotherapy[J].Tumour Biol,2014,35(11):10849
[7] HUANG Y,FENG JF.Low preoperative lymphocyte to monocyte ratio predicts poor cancer-specific survival in patients with esophageal squamous cell carcinoma[J].Onco Targets Ther,2015,8:137
[8] SONG YJ,WANG LX,HONG YQ,et al.Lymphocyte to monocyte ratio is associated with response to first-line platinum-based chemotherapy and prognosis of early-stage non-small cell lung cancer patients[J].Tumour Biol,2016,37(4):5285
[9] HE J,LV P,YANG X,et al.Pretreatment lymphocyte to monocyte ratio as a predictor of prognosis in patients with early-stage triple-negative breast cancer[J].Tumour Biol,2016,37(7):9037
[10]WANG L,WANG H,XIA ZJ,et al.Peripheral blood lymphocyte to monocyte ratio identifies high-risk adult patients with sporadic Burkitt lymphoma[J].Ann Hematol,2015,94(10):1645
[11]NISHIJIMA TF,MUSS HB,SHACHAR SS,et al.Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: A systematic review and meta-analysis[J].Cancer Treat Rev,2015,41(10):971
[12]GRIVENNIKOV SI,GRETEN FR,KARIN M.Inflammation,and cancer[J].Cell,2010,140(6):883
[13]OH BS,JANG JW,KWON JH,et al.Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma[J].BMC Cancer,2013,13:78
[14]MANO Y,SHIRABE K,YAMASHITA Y,et al.Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis[J].Ann Surg,2013,258(2):301
[15]FU SJ,SHEN SL,LI SQ,et al.Prognostic value of preoperative peripheral neutrophil-to-lymphocyte ratio in patients with HBV-associated hepatocellular carcinoma after radical hepatectomy[J].Med Oncol,2013,30(4):721
[16]TEMPLETON AJ,MCNAMARA MG,SERUGA B,et al.Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis[J].J Natl Cancer Inst,2014,106(6):124
[17]FU JL,ZHANG Z,ZHOU L,et al.Impairment of CD4(+)cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma[J].Hepatology,2013,58(1):139
[18]FU JL,XU DP,LIU ZW,et al.Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients[J].Gastroenterology,2007,132(7):2328
[19]郑乔丹,吴文苑,陈月.肿瘤相关巨噬细胞在肝癌细胞生长和转移中的作用[J].世界华人消化杂志,2012,20(30):2907
[20]REN QQ,FU SJ,ZHAO Q,et al.Prognostic value of preoperative peripheral monocyte count in patients with hepatocellular carcinoma after liver transplantation[J].Tumour Biol,2016,37(7):8973
[21]SHEN SL,FU SJ,HUANG XQ,et al.Elevated preoperative peripheral blood monocyte count predicts poor prognosis for hepatocellular carcinoma after curative resection[J].BMC Cancer,2014,14:744

相似文献/References:

[1]王振军,胡鸿涛,黎海亮#.肝动脉热灌注化疗栓塞对原发性肝癌碘化油沉积及疗效的影响[J].郑州大学学报(医学版),2015,(05):718.
[2]崔 晗),朱艺伟),游 杰),等.四种炎症标志物对HBV相关原发性肝癌术后预后的预测价值[J].郑州大学学报(医学版),2018,(01):93.[doi:10.13705/j.issn.1671-6825.2017.05.072]
 CUI Han),ZHU Yiwei),YOU Jie),et al.Value of 4 inflammatory biomarkers in prognosis of patients with hepatitis B virus-related hepatocellular carcinoma after radical operation[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(02):93.[doi:10.13705/j.issn.1671-6825.2017.05.072]

备注/Memo

备注/Memo:
*国家自然科学基金面上项目 81372679; 河南省医学科技攻关项目资助课题 201203060
#通信作者,男,1962年10月生,博士,教授,研究方向:营养与疾病,E-mail:lqjnutr@zzu.edu.cn
更新日期/Last Update: 2017-03-20