[1]徐 亮),李 明),陈会会),等.心肾综合征患者预后影响因素分析*[J].郑州大学学报(医学版),2017,(03):306-309.[doi:10.13705/j.issn.1671-6825.2017.03.016]
 XU Liang),LI Ming),CHEN Huihui),et al.Prognosis influencing factors of patients with cardiorenal syndrome[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(03):306-309.[doi:10.13705/j.issn.1671-6825.2017.03.016]
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心肾综合征患者预后影响因素分析*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年03期
页码:
306-309
栏目:
应用研究
出版日期:
2017-05-15

文章信息/Info

Title:
Prognosis influencing factors of patients with cardiorenal syndrome
作者:
徐 亮1)李 明1)陈会会2)赵根尚1)#
1)郑州大学第二附属医院心血管外科 郑州 450014 2)河南省胸科医院检验科 郑州 450000
Author(s):
XU Liang1)LI Ming1)CHEN Huihui2)ZHAO Genshang1)
1)Department of Cardiovascular Surgery,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450014 2)Clinical Laboratory, Henan Provincial Chest Hospital, Zhengzhou 450000
关键词:
心肾综合征 影响因素 预后
Keywords:
cardiorenal syndrome influencing factor prognosis
分类号:
R541
DOI:
10.13705/j.issn.1671-6825.2017.03.016
摘要:
目的:探讨心肾综合征(CRS)预后的影响因素。方法:收集104例CRS患者的临床资料,并对其进行2 a随访,根据随访期间是否发生心血管不良事件或心源性猝死分为预后较好组(n=52)和预后不良组(n=48),对两组心血管不良事件或心源性猝死发生情况及心肾相关指标进行比较,采用Cox比例风险回归筛选CRS预后的独立影响因素。结果:与预后较好组比较,预后不良组血浆尿素、肌酐、尿酸、胱抑素-C水平均升高,左室射血分数、肾小球滤过率降低,低NT-proBNP水平的患者比例较低(P<0.05)。其中左室射血分数[β=0.911, RR(95%CI)=2.487(1.293~4.782)]和血浆肌酐水平[β=1.034,RR(95%CI)=2.813(1.464~5.404)]是CRS预后的独立危险因素。结论:左室射血分数和血浆肌酐水平是预测CRS预后的良好指标。
Abstract:
Aim: To explore the prognosis influencing factors of cardiorenal syndrome(CRS).Methods: A total of 104 CRS patients were selected. According to the occurrence of adverse cardiovascular events or sudden cardiac death during 2 years follow-up, the patients were allocated into two groups: good prognosis group(n=52)and poor prognosis group(n=48). The cases developed adverse cardiovascular events or sudden cardiac death and the indexes of heart and kidney of the two groups were compared statistically, and Cox regression model was established to identify independent influencing factors of CRS prognosis.Results: Compared with those of the good prognosis group, the plasma levels of urea, creatinine, uric acid and cystatin-C in poor prognosis group were higher, and left ventricular ejection fraction(LVEF)and glomerular filtration rate were lower,the proportation of the patients with low plasm level of NT-proBNP was lower(P<0.05).LVEF[β=0.911, RR(95%CI)=2.487(1.293-4.782)] and serum creatinine[β=1.034, RR(95%CI)=2.813(1.464-5.404)] were the independent risk factors of CRS.Conclusion: LVEF and serum creatinine are good indexes to predict the prognosis of CRS.

参考文献/References:

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备注/Memo

备注/Memo:
*河南省教育厅科技攻关项目 162102310200
#通信作者,男,1962年4月生,硕士,教授,主任医师,研究方向:心血管疾病的基础与临床,E-mail:zgszzdx@tom.com
更新日期/Last Update: 2017-05-20