[1]潘双杰,何远宏#,王 楠,等.羟乙基淀粉对急性缺血性脑卒中患者肾功能的影响[J].郑州大学学报(医学版),2017,(03):353-355.[doi:10.13705/j.issn.1671-6825.2017.03.027]
 PAN Shuangjie,HE Yuanhong,WANG Nan,et al.Effect of hydroxyethyl starch 130/0.4 sodium chloride injection on renal function in patients with acute ischemic stroke[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(03):353-355.[doi:10.13705/j.issn.1671-6825.2017.03.027]
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羟乙基淀粉对急性缺血性脑卒中患者肾功能的影响()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年03期
页码:
353-355
栏目:
应用研究
出版日期:
2017-05-15

文章信息/Info

Title:
Effect of hydroxyethyl starch 130/0.4 sodium chloride injection on renal function in patients with acute ischemic stroke
作者:
潘双杰何远宏#王 楠郝东杰
郑州大学第五附属医院神经内科 郑州 450052
Author(s):
PAN Shuangjie HE Yuanhong WANG NanHAO Dongjie
Department of Neurology,the Fifth Affiliated Hospital,Zhengzhou University,Zhengzhou 450052
关键词:
羟乙基淀粉 急性缺血性脑卒中 肾功能
Keywords:
hydroxyethyl starch acute ischemic stroke renal function
分类号:
R743.3
DOI:
10.13705/j.issn.1671-6825.2017.03.027
摘要:
目的:探究羟乙基淀粉(HES)对急性缺血性脑卒中患者肾功能的影响。方法:选择急性缺血性脑卒中患者62例作为试验组,在常规治疗的基础上,给予HES130/0.4氯化钠500 mL静脉滴注,1次/d,疗程14 d。55例急性缺血性脑卒中患者作为对照组,给予常规治疗。收集入院时、治疗第7天、治疗第14天、治疗后第1个月及治疗后第3个月时的神经功能缺损程度(NIHSS评分)、日常生活能力指数(BI)及肾功能变化情况。结果:2组患者入院时的传统危险因素差异无统计学意义(P>0.05)。治疗后试验组患者的NIHSS评分、BI均较对照组明显改善(P<0.05); 治疗期间肌酐、尿素氮、估计肾小球滤过率(eGFR)均有恶化趋势,但均逐渐恢复。结论:HES治疗急性缺血性脑卒中患者后,其生活质量可改善明显,肾功能在治疗后均逐渐恢复。
Abstract:
Aim: To explore the effect of hydroxyethyl starch(HES)130/0.4 sodium chloride injection on acute ischemic stroke patients' renal function.Methods: A total of 62 hospitalized patients with acute ischemic stroke were chosen as trail group,and were given 500 mL HES 130/0.4 sodium chloride injection once per day for 14 days based on conventional treatment. Another 55 hospitalized patients with acute ischemic stroke(control group)were given conventional treatment. The NIHSS,daily life index and changes of renal function on the 7th day,the 14th day after treatment as well as after 1 month and 3 months were collected.Results: There were no differences in the traditional risk factors between the 2 groups on admission; all patients' NIHSS, daily life index after treatment improved significantly than on admission(P<0.05).The creatinine, urea nitrogen and estimated glomerular filtration rate had a degradation trend during the treatment in the trial group(P<0.05), however,after treatment all indexes improved.Conclusion: HES 130/0.4 could cause the acute ischemic stroke patients' renal function injury, but the neurological deficits and the daily life index improved significantly after the treatment, and the situation of kidney injury treatment gets better.

参考文献/References:

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备注/Memo

备注/Memo:
#通信作者,男,1962年10月生,硕士,教授,研究方向:脑血管病的诊治,E-mail:hyhcmf@163.com
更新日期/Last Update: 2017-05-20