[1]贾萌萌),周英发)#,赵治国),等.血清胃蛋白酶原和IL23用于胃癌早期诊断的价值[J].郑州大学学报(医学版),2017,(03):366-370.[doi:10.13705/j.issn.1671-6825.2017.03.031]
 JIA Mengmeng),ZHOU Yingfa),ZHAO Zhiguo),et al.Value of serum pepsinogen and IL-23 in early diagnosis of gastric cancer[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(03):366-370.[doi:10.13705/j.issn.1671-6825.2017.03.031]
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血清胃蛋白酶原和IL23用于胃癌早期诊断的价值()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年03期
页码:
366-370
栏目:
应用研究
出版日期:
2017-05-15

文章信息/Info

Title:
Value of serum pepsinogen and IL-23 in early diagnosis of gastric cancer
作者:
贾萌萌1)周英发1)# 赵治国1)刘 超1)郑紫恒1)黄艳玲2)温 静2) 任景丽3)
1)郑州大学第二附属医院消化内科 郑州 450014 2)郑州大学第二附属医院消化内镜室 郑州 450014 3)郑州大学第二附属医院病理科 郑州 450014
Author(s):
JIA Mengmeng1) ZHOU Yingfa1)ZHAO Zhiguo1)LIU Chao1)ZHENG Ziheng1)HUANG Yanling2)WEN Jing2)REN Jingli3)
1)Department of Gastroenterology, the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014 2)Department of Digestive Endoscopy Room, the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014 3)Department of Pathology, the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014
关键词:
胃蛋白酶原 IL-23 幽门螺杆菌 胃癌
Keywords:
pepsinogen IL-23 Helicobacter pylori gastric cancer
分类号:
R735.2
DOI:
10.13705/j.issn.1671-6825.2017.03.031
摘要:
目的:探讨血清胃蛋白酶原(PG)和IL-23用于胃癌早期诊断的价值。方法:收集40例慢性非萎缩性胃炎、38例单纯慢性萎缩性胃炎、33例慢性萎缩性胃炎伴肠上皮化生、30例异型增生及36例胃癌患者的空腹外周血,采用乳胶增强免疫比浊法测定血清PG亚群PGⅠ、PGⅡ的水平,采用ELISA法测定血清IL-23的水平。分析患者血清PGⅠ和IL-23的相关性。采用ROC分析血清PGⅠ、PGⅠ/PGⅡ(PGR)及IL-23对胃癌早期诊断的价值。结果:人胃黏膜癌变过程中血清PGⅠ、PGR下降,IL-23升高。血清PGⅠ与IL-23水平在慢性萎缩性胃炎伴肠上皮化生和胃癌组呈负相关(r=-0.87、-0.73,P<0.001)。ROC结果显示血清PGR、PGⅠ、IL-23诊断胃癌的AUC值依次为0.99、0.94、0.86。结论:血清PGⅠ、PGR、IL-23可用于胃癌及胃癌癌前病变的大规模筛查。
Abstract:
Aim: To investigate the value of serum pepsinogen and IL-23 in the early diagnosis of gastric cancer.Methods: The peripheral blood samples of patients suffering from chronic non-atrophic gastritis(n=40), chronic atrophic gastritis without intestinal metaplasia(IM)(n=38), chronic atrophic gastritis with IM(n=33), gastric epithelial dysplasia(n=30)and gastric cancer(n=36). Latex-enhanced immunoturbidimetry method was used to quantitatively determine the serum pepsinogen subgroups(PGⅠ, PGⅡ). ELISA was used for determining the level of IL-23.Correlation between PGⅠ and IL-23 in serum of the patients was analyzed. The value of serum PGⅠ, PGR(PGⅠ/PGⅡ)and IL-23 in early diagnosis of gastric cancer was assessed by the receiver operating characteristic curve(ROC).Results: The serum PGⅠand PGR decreased,IL-23 increased in the process of gastric mucosal carcinogenesis. The serum PGⅠand IL-23 were negatively correlated in patients with chronic atrophic gastritis with IM and patients with gastric cancer(r=-0.87,-0.73,P<0.001). ROC results showed that the AUC values of PGR, PGⅠ and IL-23 in the diagnosis of gastric cancer were 0.99, 0.94 and 0.86.Conclusion: Serum PGⅠ, PGR, and IL-23 may be used for the screening of the patients with gastric cancer and precancerous lesions.

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备注/Memo

备注/Memo:
*江苏省科技厅社会发展项目 BE2011647
#通信作者,男,1969年10月生,博士,副主任医师,研究方向:消化道肿瘤,E-mail:yfzhou69@163.com
更新日期/Last Update: 2017-05-20