[1]杨 志,李 宁,廖光星,等.乳腺癌原发灶弥散加权成像在预测腋窝淋巴结转移中的应用价值*[J].郑州大学学报(医学版),2017,(04):448-451.[doi:10.13705/j.issn.1671-6825.2017.04.018]
 YANG Zhi,LI Ning,LIAO Guangxing,et al.Predictive value of diffusion weighted imaging of primary foci in cases of breast cancer with axillary lymph node metastasis[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(04):448-451.[doi:10.13705/j.issn.1671-6825.2017.04.018]
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乳腺癌原发灶弥散加权成像在预测腋窝淋巴结转移中的应用价值*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年04期
页码:
448-451
栏目:
应用研究
出版日期:
2017-07-15

文章信息/Info

Title:
Predictive value of diffusion weighted imaging of primary foci in cases of breast cancer with axillary lymph node metastasis
作者:
杨 志李 宁廖光星陆静佳方建芸杨鸿宇柴 华李党生#肖国有
广西医科大学附属肿瘤医院核医学科 南宁 530021
Author(s):
YANG Zhi LI Ning LIAO Guangxing LU Jingjia FANG Jianyun YANG Hongyu CHAI Hua LI Dangsheng XIAO Guoyou
Department of Nuclear Medicine, the Affiliated Tumor Hospital, Guangxi Medical University, Nanning 530021
关键词:
乳腺癌 弥散加权成像 腋窝淋巴结 转移
Keywords:
breast cancer diffusion weighted imaging axillary lymph node metastasis
分类号:
R445.2
DOI:
10.13705/j.issn.1671-6825.2017.04.018
摘要:
目的:探讨乳腺癌原发灶磁共振弥散加权成像(DWI)在腋窝淋巴结转移预测中的应用价值。方法:回顾性分析2014年1月至2015年6月广西医科大学附属肿瘤医院33例经病理证实为乳腺浸润性导管癌患者的DWI图像及病理学信息,包括病灶大小、信号均匀性、原发灶表观扩散系数(ADC)值、腋窝淋巴结长径及脉管癌栓等,分析各因素与腋窝淋巴结转移的关系以及原发灶ADC值在腋窝淋巴结转移的诊断效能。结果:腋窝淋巴结转移组原发灶ADC值低于无腋窝淋巴结转移组ADC值,差异有统计学意义(P=0.013)。单因素分析显示,病灶直径、ADC值、腋窝淋巴结直径在有无腋窝淋巴结转移中的差异有统计学意义(P<0.05)。根据ADC值绘制诊断腋窝淋巴结转移的ROC曲线,曲线下面积AUC=0.791(P=0.005,95%CI=0.630~0.952),以0.885×10-3 mm2/s为诊断界值,诊断的灵敏度和特异度分别为84.2%、71.4%。结论:乳腺癌原发灶DWI在腋窝淋巴结转移中有一定的预测价值,原发灶ADC值是重要的诊断参考指标。
Abstract:
Aim: To evaluate the diagnostic value of magnetic resonance diffusion weighted imaging(DWI)of breast cancer primary foci in the patients with axillary lymph node metastasis.Methods: A total of 33 patients with breast cancer admitted in our hospital from January 2014 to June 2015 were selected, who were confirmed as breast infiltrating ductal carcinoma by pathology. DWI and pathology information of the patients were retrospectively analyzed, including the lesion size, signal uniformity, ADC values,the length of axillary lymph node, lymphatic vessel tumor emboli and sentinel lymph node. The relationship between various factors and axillary lymph node metastasis were analyzed, and compared the value of sentinel lymph node biopsy and primary foci ADC values in the diagnosis of axillary lymph node metastasis.Results: The ADC values between axillary lymph node metastasis group and without axillary lymph node metastasis group had significant difference(P=0.013). Single factor analysis showed that the size of primary foci, ADC value, and the maximum diameter of axillary lymph node were related with axillary lymph node metastasis(P<0.05). Drawing the ROC curve according to the ADC values, the AUC aws 0.791(P=0.005, 95%CI=0.630-0.952), when the threshold of ADC was set at 0.885×10-3 mm2/s, the diagnostic sensitivity and specificity were 84.2% and 71.4%, respectively.Conclusion: Primary foci DWI of breast cancer provides is a predictive value in the patients with axillary lymph node metastasis, and ADC values is an important diagnostic index.

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备注/Memo

备注/Memo:
*广西壮族自治区卫计委课题 Z2016498,Z2016472; 广西教育厅教学改革课题 2016JGB186
#通信作者,男,1962年7月生,本科,副主任医师,研究方向:肿瘤核医学及MRI影像诊断,E-mail:xgy725@aliyun.com
更新日期/Last Update: 2017-07-20