[1]贾 欣,冯倩华,张宛霞,等.透明质酸修饰的氧化石墨烯负载米托蒽醌载药体系在乳腺癌模型裸鼠体内的药动学特征和组织分布*[J].郑州大学学报(医学版),2017,(05):594-598.[doi:10.13705/j.issn.1671-6825.2017.05.019]
 JIA Xin,FENG Qianhua,ZHANG Wanxia,et al.Pharmacokinetic characteristics and tissue distribution of hyaluronic acid-modified mitoxantrone-loaded graphene oxide in MCF-7 tumor bearing mice[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(05):594-598.[doi:10.13705/j.issn.1671-6825.2017.05.019]
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透明质酸修饰的氧化石墨烯负载米托蒽醌载药体系在乳腺癌模型裸鼠体内的药动学特征和组织分布*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年05期
页码:
594-598
栏目:
应用研究
出版日期:
2017-09-15

文章信息/Info

Title:
Pharmacokinetic characteristics and tissue distribution of hyaluronic acid-modified mitoxantrone-loaded graphene oxide in MCF-7 tumor bearing mice
作者:
贾 欣冯倩华张宛霞李玉真杨雪梅杜 娟#
郑州大学药学院 郑州 450001
Author(s):
JIA XinFENG QianhuaZHANG WanxiaLI YuzhenYANG XuemeiDU Juan
School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001
关键词:
米托蒽醌 透明质酸 药动学 组织分布 小鼠 MCF-7细胞
Keywords:
mitoxantrone hyaluronic acid pharmacokinetics tissue distribution mouse MCF-7 cell
分类号:
R737.9
DOI:
10.13705/j.issn.1671-6825.2017.05.019
摘要:
目的:考察透明质酸(HA)修饰的氧化石墨烯(GO)负载米托蒽醌(MIT)载药体系(MIT/HA-GO)在乳腺癌模型裸鼠体内的药动学特征和组织分布。方法:建立MIT测定的高效液相色谱法。荷瘤小鼠由尾静脉分别注射MIT、MIT/GO以及MIT/HA-GO,用上述方法检测MIT浓度,分析其在小鼠体内的药动学特征及在心、肝、肺、肾、瘤等部位的分布情况。结果:与MIT组相比,MIT/GO组及MIT/HA-GO组MIT的血循环时间均延长,且在心、肺、肾的AUC降低; MIT/GO及MIT/HA-GO在肿瘤组织的靶向效率分别为MIT的1.55和2.61倍。结论:MIT/HA-GO载药体系降低了MIT的全身毒副作用并提高了对肿瘤部位的靶向性。
Abstract:
Aim: To investigate the pharmacokinetic characteristics and tissue distribution of hyaluronic acid(HA)-modified mitoxantrone(MIT)-loaded graphene oxide(GO)in the MCF-7 tumor bearing mice.Methods: The mice were injected with MIT, MIT/GO and MIT/HA-GO via tail vein, respectively. And the pharmacokinetics study and drug distrubution in major organs of the three different formulations were determined by HPLC.Results: Compared with MIT, MIT/GO and MIT/HA-GO possessed prolonged circulation features and decreased the AUC in heart, lung and kidney. And the tumor targeting efficiency of MIT/GO and MIT/HA-GO were 1.55 and 2.61 times as compared with that of MIT, respectively.Conclusion: The HA-mediated MIT-loaded GO decreases the systemic toxicity of MIT and increases the tumor targeting efficiency.

参考文献/References:

[1] HOU L,FENG Q,WANG Y,et al.Multifunctional hyaluronic acid modified graphene oxide loaded with mitoxantrone for overcoming drug resistance in cancer[J].Nanotechnology,2016,27(1):15701
[2] 欧阳学农,王文武,彭永海,等.GMEP方案治疗难治性或复发性非霍奇金淋巴瘤的近期疗效报告[J].解放军医学杂志,2005,30(8):726
[3] 雷巧,陶静楠.蒽环类药物相关研究进展[J].医学信息,2015,28(10):340
[4] HOU L,FENG QH,WANG YT,et al.Multifunctional nanosheets based on hyaluronic acid modified graphene oxide for tumor-targeting chemophotothermal therapy[J].J Nanoparticle Res,2015,17(3):162
[5] 梁春丽,沈国鹏,王舒雨,等.5-氟尿嘧啶固体脂质纳米粒对S180腹水瘤小鼠的抑瘤作用[J].郑州大学学报(医学版),2010,45(4):579
[6] 王艳芝,郑甲信,徐炳欣,等.盐酸小檗碱固体脂质纳米粒包封率的聚结离心法测定[J].郑州大学学报(医学版),2009,44(1):188
[7] CHOI KY,SARAVANAKUMAR G,PARK JH,et al.Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer[J].Colloids Surf B Biointerfaces,2012,99(1):82
[8] 熊素彬,陆彬,杨红,等.RP-HPLC法研究米托蒽醌白蛋白纳米粒在大鼠的体内分布和淋巴结靶向性[J].药物分析杂志,2006,26(8):1043
[9] 张良珂,侯世祥,卢懿,等.叶酸受体介导米托蒽醌白蛋白纳米粒的体内分布及药效学研究[J].中国药学杂志,2007,42(9):676
[10]庄婕,石勇平,平其能,等.壳聚糖包覆米托蒽醌脂质体在荷瘤小鼠体内的组织分布及药效学[J].中国药科大学学报,2010,41(4):353
[11]ZHANG RX,CAI P,ZHANG T,et al.Polymer-lipid hybrid nanoparticles synchronize pharmacokinetics of co-encapsulated doxorubicin-mitomycin C and enable their spatiotemporal co-delivery and local bioavailability in breast tumor[J].Nanomedicine,2016,12(5):1279
[12]张兰,杜艳玲,刘勋涛,等.盐酸米托蒽醌脂质体的制备及药效学、药动学研究[J].中国药学杂志,2013,48(17):1475
[13]EDELMAN R,ASSARAF YG,LEVITZKY I,et al.Hyaluronic acid-serum albumin conjugate-based nanoparticles for targeted cancer therapy[J].Oncotarget,2017,8(15):24337
[14]WANG Z,CHEN Z,LIU Z,et al.A multi-stimuli responsive gold nanocage-hyaluronic platform for targeted photothermal and chemotherapy[J].Biomaterials,2014,35(36):9678

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目 81202485,81273451
#通信作者,女,1969年11月生,硕士,副教授,研究方向:药事管理学,E-mail:dujuan2004@zzu.edu.cn
更新日期/Last Update: 2017-09-20