[1]谭 丽△,刘昕媛,楚喜英,等.不同促排卵与激素替代治疗方案对人种植窗期子宫内膜LIF、IL-1β与整合素αVβ3表达的影响*[J].郑州大学学报(医学版),2017,(05):605-609.[doi:10.13705/j.issn.1671-6825.2017.05.022]
 TAN Li,LIU Xinyuan,CHU Xiying,et al.Effects of different ovarian stimulation and hormone replacement therapy on expressions of LIF, IL-1β and integrin αVβ3 in human endometrium during the implantation window[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(05):605-609.[doi:10.13705/j.issn.1671-6825.2017.05.022]
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不同促排卵与激素替代治疗方案对人种植窗期子宫内膜LIF、IL-1β与整合素αVβ3表达的影响*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年05期
页码:
605-609
栏目:
应用研究
出版日期:
2017-09-15

文章信息/Info

Title:
Effects of different ovarian stimulation and hormone replacement therapy on expressions of LIF, IL-1β and integrin αVβ3 in human endometrium during the implantation window
作者:
谭 丽刘昕媛楚喜英卢 娜项云改宋玉霞李朋粉
郑州大学第二附属医院生殖中心 郑州 450014
Author(s):
TAN LiLIU XinyuanCHU XiyingLU NaXIANG YungaiSONG YuxiaLI Pengfen
Reproductive Center, the Second Affiliated Hospital,Zhengzhou University, Zhengzhou 450014
关键词:
诱发排卵 控制性超促排卵 激素替代治疗 子宫内膜容受性
Keywords:
induced ovulation controlled ovarian hyperstimulation hormone replacement therapy endometrial receptivity
分类号:
R715
DOI:
10.13705/j.issn.1671-6825.2017.05.022
摘要:
目的:探讨诱发排卵、控制性超促排卵(COH)、激素替代治疗(HRT)方案对人种植窗期子宫内膜容受性的影响。方法:选取60例取消移植的患者作为研究对象。20例为自然周期排卵,10例为诱发排卵,20例为COH方案,10例采用HRT方案。每个方案分别于排卵后第5、6天(D5、D6)采集半数研究对象的内膜,免疫组化SP法检测LIF、IL-1β与整合素αVβ3蛋白的表达。结果:相同方案的D5与D6内膜间比较,3种蛋白的表达量差异均无统计学意义(P>0.05)。诱发排卵组、COH组、HRT组3种蛋白在内膜中的相对表达量均低于自然周期组,其中诱发排卵组最低,HRT组高于COH组(P<0.05)。结论:HRT方案对人种植窗期子宫内膜容受性的影响最小。
Abstract:
Aim: To observe the outcome of different protocols,induced ovulation, controlled ovarian hyperstimulation(COH)and hormone replacement therapy(HRT), on human endometrial receptivity during the implantation window.Methods: A total of 60 patients were enrolled, among them, 10 cases underwent induced ovulation, 20 cases underwent COH, 10 cases received HRT, and 20 cases were natural ovulation cycle. Ovarian endometrium on the 5th or 6th day(D5 or D6)after ovulation of the half subjects were collected to detect LIF,IL-1β, and integrin αVβ3 by immunohistochemical SP method, respectively.Results: The expressions of these three proteins in endometrium were natural ovulation cycle group>HRT group>COH group>induced ovulation group(P<0.05). The expressions of these three proteins in endometrium on D5 and D6 had no statistical difference(P>0.05).Conclusion: HRT might have the minest injury on the endometrial receptivity.

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备注/Memo

备注/Memo:
*河南省教育厅科技攻关项目 142300410240
△女,1964年4月生,博士,主任医师,教授,研究方向:辅助生殖技术与生殖内分泌,E-mail:litan668@126.com
更新日期/Last Update: 2017-09-20