[1]张军喜),王鹏高),蒋丽芳)#,等.先天性心脏病危险因素病例对照研究*[J].郑州大学学报(医学版),2017,(05):617-620.[doi:10.13705/j.issn.1671-6825.2017.05.025]
 ZHANG Junxi),WANG Penggao),JIANG Lifang),et al.Case-control study on risk factors of congenital heart disease[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(05):617-620.[doi:10.13705/j.issn.1671-6825.2017.05.025]
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先天性心脏病危险因素病例对照研究*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年05期
页码:
617-620
栏目:
应用研究
出版日期:
2017-09-15

文章信息/Info

Title:
Case-control study on risk factors of congenital heart disease
作者:
张军喜1)王鹏高2)蒋丽芳1)#柴 健1)马颖辉1)孙盼盼1)
1)河南省人口和计划生育科学技术研究院; 国家卫生计生委出生缺陷预防重点实验室 郑州 450002 2)郑州市儿童医院心胸外科 郑州 450053
Author(s):
ZHANG Junxi1)WANG Penggao2)JIANG Lifang1)CHAI Jian1)MA Yinghui1)SUN Panpan1)
1)Henan Provincial Research Institute for Population and Family Planning; Key Laboratory of Birth Defects Prevention, National Health and Family Planning Commission Zhengzhou 450002 2)Department of Thoracic and Cardiovascular Surgery, Zhengzhou Children's Hospital, Zhengzhou 450053
关键词:
先天性心脏病 危险因素 病例对照研究
Keywords:
congenital heart disease risk factor case-control study
分类号:
R541.1
DOI:
10.13705/j.issn.1671-6825.2017.05.025
摘要:
目的:探讨先天性心脏病(CHD)发生的危险因素。方法:采用1GA6FA1配对病例对照研究,对病例组和对照组各165名儿童的父母进行问卷调查。采用条件logistic回归分析方法筛选出与CHD发生相关的独立危险因素。结果与结论:最终筛选出与CHD发生相关的4个独立危险因素,分别为母亲生育过CHD患儿(OR=20.230,95%CI=6.012~68.078)、停经后接触有毒有害物质(OR=4.047,95%CI=1.665~9.835)、停经后服用过药物(OR=2.617,95%CI=1.224~5.594)和父亲吸烟(OR=4.666,95%CI=1.983~10.980)。
Abstract:
Aim: To explore the risk factors of congenital heart disease(CHD).Methods: A population-based 1GA6FA1 matched case-control study on CHD patients was conducted. Children's parents were interviewed with a unified face-to-face questionnaire. Information of 165 pairs of children with CHD was analyzed.The data were analyzed by multivariate conditional logistic regression analysis.Results and Conclusion: A total of 4 independent risk factors were screened: the birth history of CHD(OR=20.230,95%CI=6.012-68.078), exposure to toxic and hazardous substances post menolipsis(OR=4.047,95%CI=1.665-9.835), the use of drugs post menolipsis(OR=2.617,95%CI=1.224-5.594)and the husband's smoking(OR=4.666,95%CI=1.983-10.980).

参考文献/References:

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备注/Memo

备注/Memo:
*河南省科技厅基本研究项目 2015JBKY005
#通信作者,女,1963年6月生,研究员,研究方向:生殖健康,E-mail:jiangzz66@163.com
更新日期/Last Update: 2017-09-20