[1]文夏杰),鲁凤民),吕全军)#.术前凝血功能指标对HBV相关肝细胞癌术后生存状况的评估价值*[J].郑州大学学报(医学版),2017,(06):725-728.[doi:10.13705/j.issn.1671-6825.2017.06.015]
 WEN Xiajie),LU Fengmin),LYU Quanjun).Estimate value of blood coagulation function index before surgery for survival of HBV-related hepatocellular carcinoma patients after hepatectomy[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2017,(06):725-728.[doi:10.13705/j.issn.1671-6825.2017.06.015]
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术前凝血功能指标对HBV相关肝细胞癌术后生存状况的评估价值*()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2017年06期
页码:
725-728
栏目:
应用研究
出版日期:
2017-11-15

文章信息/Info

Title:
Estimate value of blood coagulation function index before surgery for survival of HBV-related hepatocellular carcinoma patients after hepatectomy
作者:
文夏杰1)鲁凤民1)吕全军2)#
1)郑州大学公共卫生学院流行病学教研室 郑州 450001
2)郑州大学公共卫生学院营养与食品卫生学教研室 郑州 450001
Author(s):
WEN Xiajie1) LU Fengmin1) LYU Quanjun2)
1)Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001
2)Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001
关键词:
肝细胞癌 预后 凝血酶原时间 国际标准化比值 纤维蛋白原
Keywords:
hepatocellular carcinoma prognosis prothrombin time international normalized ratio fibrinogen
分类号:
R735.7
DOI:
10.13705/j.issn.1671-6825.2017.06.015
摘要:
目的:探讨术前凝血功能指标凝血酶原时间(PT)、国际标准化比值(IMR)及纤维蛋白原(FIB)对HBV相关肝细胞癌患者肝癌根治性切除术后预后的评估价值。方法:收集381例2009年2月至2013年7月在河南省肿瘤医院进行肝切除手术的HBV相关肝细胞癌患者的术前临床资料,进行术后生存状况随访,使用Cox回归模型进行生存分析,确定术前PT、INR和FIB状态对患者术后生存状况的评估价值。结果:经Cox回归筛选,术前INR和FIB升高是HBV相关肝细胞癌术后生存的独立危险因素,其RR(95%CI)分别为1.833(1.182~2.842)、1.778(1.256~2.516)。结论:术前INR和FIB有评估HBV相关肝细胞癌患者术后预后的价值。
Abstract:
Aim: To investigate the estimate value of prothrombin time(PT), international normalized ratio(INR)and fibrinogen(FIB)for the survival of the HBV-related hepatocellular carcinoma(HCC)patients accepting hepatectomy.Methods: Clinical pathological data of 381 HBV-related HCC patients who were treated by curative hepatectomy between February 2009 and July 2013 in Henan Cancer Hospital were collected. Survival analysis was done using Cox regression.Results: INR and FIB were independent risk factors for the survival of HBV-related post-surgery HCC patients, and RR(95%CI)were 1.833(1.182-2.842)and 1.778(1.256-2.516), respectively.Conclusion: INR and FIB before surgery have prognostic value for HBV-related HCC patients accepting hepatectomy.

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备注/Memo

备注/Memo:
*国家自然科学基金面上项目 81372679
#通信作者,男,1962年10月生,博士,教授,研究方向:营养与疾病、肿瘤相关研究,E-mail:lqjnutr@zzu.edu.cn
更新日期/Last Update: 2017-11-20