[1]刘怡文,孙 蔚,齐义军,等.食管鳞癌组织中GSK3β表达的临床意义[J].郑州大学学报(医学版),2018,(01):21-24.[doi:10.13705/j.issn.1671-6825.2016.12.060]
 LIU Yiwen,SUN Wei,QI Yijun,et al.Clinical significance of GSK3β expression in esophageal squamous cell carcinoma tissue[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(01):21-24.[doi:10.13705/j.issn.1671-6825.2016.12.060]
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食管鳞癌组织中GSK3β表达的临床意义()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年01期
页码:
21-24
栏目:
食管癌研究
出版日期:
2018-01-20

文章信息/Info

Title:
Clinical significance of GSK3β expression in esophageal squamous cell carcinoma tissue
作者:
刘怡文孙 蔚齐义军高社干
河南科技大学第一附属医院临床医学院; 河南省肿瘤表观遗传重点实验室 河南洛阳 471003
Author(s):
LIU Yiwen SUN Wei QI Yijun GAO Shegan
College of Clinical Medicine, the First Affiliated Hospital, Henan University of Science and Technology; Henan Key Laboratory of Epigenetics, Luoyang, Henan 471003
关键词:
食管鳞癌 GSK3β 预后
Keywords:
esophageal squamous cell carcinoma GSK3β prognosis
分类号:
R735.1
DOI:
10.13705/j.issn.1671-6825.2016.12.060
摘要:
目的:分析GSK3β在食管鳞癌组织中的表达及临床意义。方法:采用实时荧光定量PCR、Western blot、免疫组化等方法检测GSK3β在52例食管鳞癌及相应癌旁组织中的表达,并采用Cox回归分析GSK3β表达与食管鳞癌患者术后预后的关系。结果:食管鳞癌组织中GSK3β mRNA及蛋白表达水平、阳性表达率均高于相应癌旁组织(P<0.05)。Cox回归分析表明GSK3β为食管鳞癌患者术后预后的独立危险因素(β=1.095,P=0.026)。结论:GSK3β表达可能促进了食管鳞癌的发生发展; GSK3β可能成为食管鳞癌靶向治疗的分子靶点之一。
Abstract:
Aim: To characterize the expression level of GSK3β and its clinical significance in esophageal squamous cell carcinoma(ESCC)tissue.Methods: The mRNA and protein expression levels of GSK3β in 52 cases of ESCC and matched adjacent tissue samples were determined by Real-time PCR, Western blot and immunohistochemistry, respectively, and the correlation between the expression of GSK3β and the prognosis of patients was also analyzed using Cox regression.Results: The mRNA and protein expression levels, and the positive rate of GSK3β in ESCC tissue were higher compared with those in adjacent noncancerous mucosa tissue(P<0.05). Cox regression analysis showed that GSK3β was an independent risk factor for the prognosis of patients with ESCC(β=1.095,P=0.026).Conclusion: GSK3β expression may promote the development of ESCC, and GSK3β may be one of the molecular targets for treatment of ESCC.

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备注/Memo

备注/Memo:
【基金项目】国家自然科学基金资助项目(81472234)
【作者简介】高社干,通信作者,男,1968年10月生,博士,教授,主任医师,研究方向:消化道肿瘤的基础与临床,E-mail:gsg112258@163.com
更新日期/Last Update: 2018-01-20