[1]高晨皓,王金兰,石佩玉,等.甲状腺功能减退症与卒中发病的meta分析[J].郑州大学学报(医学版),2018,(01):109-114.[doi:10.13705/j.issn.1671-6825.2017.05.102]
 GAO Chenhao,WANG Jinlan,SHI Peiyu,et al.A meta-analysis on hypothyroidism and the risk of stroke[J].JOURNAL OF ZHENGZHOU UNIVERSITY(MEDICAL SCIENCES),2018,(01):109-114.[doi:10.13705/j.issn.1671-6825.2017.05.102]
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甲状腺功能减退症与卒中发病的meta分析()
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《郑州大学学报(医学版)》[ISSN:1671-6825/CN:41-1340/R]

卷:
期数:
2018年01期
页码:
109-114
栏目:
应用研究
出版日期:
2018-01-20

文章信息/Info

Title:
A meta-analysis on hypothyroidism and the risk of stroke
作者:
高晨皓王金兰石佩玉安 颖乔 月
郑州大学第二附属医院神经内科 郑州 450014
Author(s):
GAO ChenhaoWANG JinlanSHI PeiyuAN Ying QIAO Yue
Department of Neurology,the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014
关键词:
甲状腺功能减退症 卒中 病例对照研究 队列研究 meta分析
Keywords:
hypothyroidism stroke case-control study cohort study meta-analysis
分类号:
R743.3
DOI:
10.13705/j.issn.1671-6825.2017.05.102
摘要:
目的:评估甲状腺功能减退症(甲减)与卒中发病的关系。方法:检索Pubmed、Embase、Medline、Google Scholar、Cochrane Library、Web of Science、CNKI、维普和万方数据库有关甲减与卒中关系的病例对照研究和队列研究,由2名研究员独立筛选文献及提取资料,对纳入文献采用NOS量表进行质量评价,应用Stata 12.0进行统计分析。结果:共纳入11篇相关文献(9篇队列研究,2篇病例对照研究),累积样本量238 916例,发生卒中事件6 026例。结果显示,与甲状腺功能正常者相比,甲减患者具有较高的卒中发病风险(RR=1.24,95%CI=1.02~1.52)。Meta回归分析结果提示地区和平均年龄为可能的异质性因素(P均<0.05)。亚组分析结果提示平均年龄<65岁的甲减患者卒中发病风险较甲状腺功能正常者高(RR=1.44,95%CI=1.02~2.04),但平均年龄<65岁的研究间存在较高的异质性; 基于亚洲人群亚组研究的异质性较欧洲和美洲高。敏感性分析提示本研究结果稳健性较好。本研究无明显发表偏倚。结论:甲减可能增加卒中的发病风险,平均年龄<65岁的甲减患者可能有着更高的卒中发病风险。
Abstract:
Aim: To evaluate the association between hypothyroidism and the risk of stroke.Methods: Published cohort studies and case-control studies on association between hypothyroidism and the risk of stroke were identified through a systematic search in Pubmed,Embase,Medline,Google Scholar, Cochrane Library,Web of Science,CNKI,VIP and Wanfang database.Articles were screened and data were extracted by two independent reviewers.Articles' quality was assessed using NOS scale. Stata 12.0 was used for data analysis.Results: Eleven studies(9 cohort studies and 2 case-control studies),including 238 916 participants with 6 026 stroke events were involved totally.Compared with the euthyroid group,patients with hypothyroidism had a higher risk of stroke[RR(95%CI)=1.24(1.02-1.52)].Meta-regression analysis showed that mean age and region may be potential sources of heterogeneity.Subgroup analysis indicated that hypothyroidism increased the risk of stroke in the population with mean age less than 65 years[RR(95%CI)=1.44(1.02-2.04)], but there was higher heterogeneity.Compared with Europe and America subgroups,the studies from Asia had higher heterogeneity.The results were stable indicated by sensitivity analysis without obvious publication bias.Conclusion: Hypothyroidism may lightly increase the risk of stroke,mainly influence subjects younger than 65 years.

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备注/Memo

备注/Memo:
【基金项目】郑州大学第二附属医院院内基金
【作者简介】王金兰,通信作者,女,1968年9月生,博士,教授,研究方向:脑血管疾病,E-mail:wangjinlan08@126.com
更新日期/Last Update: 2018-01-20